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01.02.2013 | Original paper

Risk factors for young-onset colorectal cancer

verfasst von: Valentina Rosato, Cristina Bosetti, Fabio Levi, Jerry Polesel, Antonella Zucchetto, Eva Negri, Carlo La Vecchia

Erschienen in: Cancer Causes & Control | Ausgabe 2/2013

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Abstract

Purpose

We investigated risk factors for colorectal cancer in early-onset cancers, to provide quantitative estimates for major selected risk factors.

Methods

We analyzed data from three Italian and Swiss case–control studies conducted between 1985 and 2009, including 329 colorectal cancer cases and 1,361 controls aged ≤45 years. We computed odds ratios (ORs) from unconditional logistic regression models, adjusted for major confounding factors.

Results

The OR of young-onset colorectal cancer was 4.50 for family history of colorectal cancer in first-degree relatives, the association being higher in subjects with affected siblings (OR 11.68) than parents (OR 3.75). The ORs of young-onset colorectal cancer were 1.56 for ≥14 drinks/week of alcohol, 1.56 for the highest tertile of processed meat, 0.40 for vegetables, 0.75 for fruit, and 0.78 for fish intake. Among micronutrients, the ORs were 0.52 for β-carotene, 0.68 for vitamin C, 0.38 for vitamin E, and 0.59 for folate. No significant associations emerged for physical activity, overweight, and diabetes.

Conclusions

This study—the largest on young-onset colorectal cancer—confirms that several recognized risk factors for colorectal cancer are also relevant determinants of young-onset colorectal cancer. Family history of colorectal cancer in particular is a stronger risk factor in young subjects, as compared to middle age and elderly ones.

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Titel: Risk factors for young-onset colorectal cancer
verfasst von: Valentina Rosato
Cristina Bosetti
Fabio Levi
Jerry Polesel
Antonella Zucchetto
Eva Negri
Carlo La Vecchia
Publikationsdatum: 01.02.2013
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 2/2013
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-0119-3

Springer Medizin

Risk factors for young-onset colorectal cancer