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01.07.2012 | Original Paper

Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma

verfasst von: Jennifer L. Kelly, Matthew T. Drake, Zachary S. Fredericksen, Yan W. Asmann, Mark Liebow, Tait D. Shanafelt, Andrew L. Feldman, Stephen M. Ansell, William R. Macon, Megan M. Herr, Alice H. Wang, Grzegorz S. Nowakowski, Timothy G. Call, Thomas M. Habermann, Susan L. Slager, Thomas E. Witzig, James R. Cerhan

Erschienen in: Cancer Causes & Control | Ausgabe 7/2012

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Abstract

Purpose

It has been hypothesized that vitamin D mediates the inverse relationship between sun exposure and non-Hodgkin lymphoma (NHL) risk reported in several recent studies. We evaluated the association of self-reported sun exposure at ages <13, 13–21, 22–40, and 41+ years and 19 single nucleotide polymorphisms (SNPs) from 4 candidate genes relevant to vitamin D metabolism (RXR, VDR , CYP24A1, CYP27B1) with NHL risk.

Methods

This analysis included 1,009 newly diagnosed NHL cases and 1,233 frequency-matched controls from an ongoing clinic-based study. Odds ratios (OR), 95 % confidence intervals (CI), and tests for trend were estimated using unconditional logistic regression.

Results

There was a significant decrease in NHL risk with increased sun exposure at ages 13–21 years (OR_{≥15 vs. ≤3 h/week} = 0.68; 95 % CI, 0.43–1.08; p _trend = 0.0025), which attenuated for older ages at exposure. We observed significant main effect associations for 3 SNPs in VDR and 1 SNP in CYP24A1: rs886441 (OR_per-allele = 0.82; 95 % CI, 0.70–0.96; p = 0.016), rs3819545 (OR_per-allele = 1.24; 95 % CI, 1.10–1.40; p = 0.00043), and rs2239186 (OR_per-allele = 1.22; 95 % CI, 1.05–1.41; p = 0.0095) for VDR and rs2762939 (OR_per-allele = 0.85; 95 % CI, 0.75–0.98; p = 0.023) for CYP24A1. Moreover, the effect of sun exposure at age 13–21 years on overall NHL risk appears to be modified by germline variation in VDR (rs4516035; p _interaction = 0.0066). Exploratory analysis indicated potential heterogeneity of these associations by NHL subtype.

Conclusion

These results suggest that germline genetic variation in VDR, and therefore the vitamin D pathway, may mediate an association between early life sun exposure and NHL risk.

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Titel: Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma
verfasst von: Jennifer L. Kelly
Matthew T. Drake
Zachary S. Fredericksen
Yan W. Asmann
Mark Liebow
Tait D. Shanafelt
Andrew L. Feldman
Stephen M. Ansell
William R. Macon
Megan M. Herr
Alice H. Wang
Grzegorz S. Nowakowski
Timothy G. Call
Thomas M. Habermann
Susan L. Slager
Thomas E. Witzig
James R. Cerhan
Publikationsdatum: 01.07.2012
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 7/2012
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-9967-0

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Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma