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01.04.2013 | Original paper

Prevalence of type-specific human papillomavirus and pap results in Chinese women: a multi-center, population-based cross-sectional study

verfasst von: En-Qi Wu, Bin Liu, Jian-Feng Cui, Wen Chen, Jian-Bing Wang, Liang Lu, Mayineur Niyazi, Chao Zhao, Sheng-Da Ren, Chang-Qing Li, Xiang-Zhen Gong, Jennifer S. Smith, Jerome L. Belinson, Kai-Li Liaw, Christine Velicer, You-Lin Qiao

Erschienen in: Cancer Causes & Control | Ausgabe 4/2013

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Abstract

Purpose

To estimate the burden of human papillomavirus (HPV) infection among sexually active women in China.

Methods

We conducted a multi-center, population-based study between May 2006 and April 2007. A total of 4,215 women aged 17–54 years were surveyed from five geographical sites: Beijing, Shanghai, Shanxi, Henan, and Xinjiang. Direct endocervical exfoliated cells were collected from consenting participants for Sure Path liquid-based cytology (BD) and HPV testing. HPV testing was performed with Hybrid Capture II (Qiagen) with high-risk and low-risk probes, and Linear Array (Roche) was utilized for HPV genotyping.

Results

Approximately 11 % of the study population had a cytological abnormality (ASCUS or worse). HPV prevalence in the entire study population was 14.3 % (age-standardized to the world standard female population 14.5 %). The most prevalent types found were HPV16 (2.9 %), HPV52 (1.7 %), HPV58 (1.5 %), HPV33 (1 %), and HPV18 (0.8 %). Patterns of HPV prevalence differed by age, geographic region, and cytology findings. However, HPV16 was predominant among all grades of cytological abnormalities for all areas.

Conclusions

Although HPV18 appeared to be less frequent among population-based samples of China, given the high prevalence of HPV 16 and 18 in high-grade squamous intraepithelial lesion (HSIL) or worse pap abnormalities, prophylactic HPV16/18 vaccines should substantially reduce the burden of cervical cancer in China.

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Titel: Prevalence of type-specific human papillomavirus and pap results in Chinese women: a multi-center, population-based cross-sectional study
verfasst von: En-Qi Wu
Bin Liu
Jian-Feng Cui
Wen Chen
Jian-Bing Wang
Liang Lu
Mayineur Niyazi
Chao Zhao
Sheng-Da Ren
Chang-Qing Li
Xiang-Zhen Gong
Jennifer S. Smith
Jerome L. Belinson
Kai-Li Liaw
Christine Velicer
You-Lin Qiao
Publikationsdatum: 01.04.2013
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 4/2013
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-013-0162-8

Springer Medizin

Prevalence of type-specific human papillomavirus and pap results in Chinese women: a multi-center, population-based cross-sectional study