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01.10.2014 | Original paper

Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

verfasst von: Helen D. Bailey, Lin Fritschi, Catherine Metayer, Claire Infante-Rivard, Corrado Magnani, Eleni Petridou, Eve Roman, Logan G. Spector, Peter Kaatsch, Jacqueline Clavel, Elizabeth Milne, John D. Dockerty, Deborah C. Glass, Tracy Lightfoot, Lucia Miligi, Jérémie Rudant, Margarita Baka, Roberto Rondelli, Alicia Amigou, Jill Simpson, Alice Y. Kang, Maria Moschovi, Joachim Schüz

Erschienen in: Cancer Causes & Control | Ausgabe 10/2014

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Abstract

Purpose

It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.

Methods

We obtained individual level data from 13 case–control studies participating in the Childhood Leukemia International Consortium. Occupational data were harmonized to a compatible format. Meta-analyses of study-specific odds ratios (ORs) were undertaken, as well as pooled analyses of individual data using unconditional logistic regression.

Results

Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93 [95 % confidence interval (CI) 0.76, 1.14]. Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 (95 % CI 0.39, 1.68) for exposure during pregnancy. For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 (95 % CI 0.65, 1.41) and 1.31 (95 % CI 0.38, 4.47), respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers. Heterogeneity among the individual studies ranged from low to modest.

Conclusions

Null findings for paternal exposure for both ALL and AML are consistent with previous reports. Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed. Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.

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Titel: Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium
verfasst von: Helen D. Bailey
Lin Fritschi
Catherine Metayer
Claire Infante-Rivard
Corrado Magnani
Eleni Petridou
Eve Roman
Logan G. Spector
Peter Kaatsch
Jacqueline Clavel
Elizabeth Milne
John D. Dockerty
Deborah C. Glass
Tracy Lightfoot
Lucia Miligi
Jérémie Rudant
Margarita Baka
Roberto Rondelli
Alicia Amigou
Jill Simpson
Alice Y. Kang
Maria Moschovi
Joachim Schüz
Publikationsdatum: 01.10.2014
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 10/2014
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-014-0441-z

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Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium