nach oben

Erschienen in:

09.11.2017 | Original paper

Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study

verfasst von: Lindsay A. Williams, Hazel B. Nichols, Katherine A. Hoadley, Chiu Kit Tse, Joseph Geradts, Mary Elizabeth Bell, Charles M. Perou, Michael I. Love, Andrew F. Olshan, Melissa A. Troester

Erschienen in: Cancer Causes & Control | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Background

Invasive lobular breast tumors display unique reproductive risk factor profiles. Lobular tumors are predominantly Luminal A subtype, and it is unclear whether reported risk factor associations are independent of molecular subtype.

Methods

Polytomous logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the associations between risk factors and histologic subtype [ductal (n = 2,856), lobular (n = 326), and mixed ductal–lobular (n = 473)] in the Carolina Breast Cancer Study (1993–2013). Three-marker immunohistochemical clinical subtypes were defined as Luminal A (ER+ or PR+/HER2-), Luminal B (ER+ or PR+/HER2+), Triple Negative (ER−/PR−/HER2-), and HER2+ (ER−/PR−/HER2+).

Results

In case–case analyses compared to ductal, lobular tumors were significantly associated with lactation duration > 12 months [OR 1.86, 95% CI (1.33–2.60)], age at first birth ≥ 26 years [OR: 1.35, 95% CI: (1.03–1.78)], and current oral contraceptive use [OR: 1.86, 95% CI: (1.08–3.20)]. Differences in risk factor associations between ductal and lobular tumors persisted after restricting to Luminal A subtype.

Conclusions

Lobular tumors were associated with older age at first birth, increased lactation duration, and current oral contraceptive use. Etiologic heterogeneity by histology persisted after restricting to Luminal A subtype, suggesting both tumor histology and intrinsic subtype play integral parts in breast cancer risk.

Nur mit Berechtigung zugänglich

The Cancer Genome Atlas Network (2012) Comprehensive molecular portraits of human breast tumors. Nature 490:61–70. https://doi.org/10.1038/nature11412.Comprehensive CrossRefPubMedCentral

Perou CM, Sørlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406:747–752. https://doi.org/10.1038/35021093 CrossRefPubMed

Arps DP, Healy P, Zhao L et al (2013) Invasive ductal carcinoma with lobular features: a comparison study to invasive ductal and invasive lobular carcinomas of the breast. Breast Cancer Res Treat 138:719–726. https://doi.org/10.1007/s10549-013-2493-2 CrossRefPubMedPubMedCentral

Makki J (2015) Diversity of breast Carcinoma: histological subtypes and clinical relevance. Clin Med Insights Pathol 8:23–31. https://doi.org/10.4137/CPath.S31563.TYPE PubMedPubMedCentral

Rosen PP (2009) Rosen’s breast pathology, third. Lippincott Williams & Wilkins, Phildelphia, PA

Millikan RC, Newman B, Tse C-K et al (2008) Epidemiology of basal-like breast cancer. Breast Cancer Res Treat 109:123–139. https://doi.org/10.1007/s10549-007-9632-6 CrossRefPubMed

Sisti JS, Collins LC, Beck AH et al (2016) Reproductive risk factors in relation to molecular subtypes of breast cancer: results from the nurses’ health studies. Int J Cancer 138:2346–2356. https://doi.org/10.1002/ijc.29968 CrossRefPubMedPubMedCentral

Ciriello G, Gatza ML, Beck AH et al (2015) Comprehensive molecular portraits of invasive lobular breast cancer. Cell 163:506–519. https://doi.org/10.1016/j.cell.2015.09.033 CrossRefPubMedPubMedCentral

Carey LA, Perou CM, Livasy CA et al (2006) Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295:2492–2502. https://doi.org/10.1001/jama.295.21.2492 CrossRefPubMed

10.

Cha YJ, Kim YH, Cho NH, Koo JS (2014) Expression of autophagy related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma. Int J Clin Exp Pathol 7:3389–3398PubMedPubMedCentral

11.

Lim ST, Yu JH, Park HK et al (2014) A comparison of the clinical outcomes of patients with invasive lobular carcinoma and invasive ductal carcinoma of the breast according to molecular subtype in a Korean population. World J Surg Oncol 12:56. https://doi.org/10.1186/1477-7819-12-56 CrossRefPubMedPubMedCentral

12.

Engstrøm MJ, Opdahl S, Vatten LJ et al (2015) Invasive lobular breast cancer: the prognostic impact of histopathological grade, E-cadherin and molecular subtypes. Histopathology 66:409–419. https://doi.org/10.1111/his.12572 CrossRefPubMed

13.

Jung S-Y, Jeong J, Shin S-H et al (2010) The invasive lobular carcinoma as a prototype luminal A breast cancer: a retrospective cohort study. BMC Cancer 10:664. https://doi.org/10.1186/1471-2407-10-664 CrossRefPubMedPubMedCentral

14.

García-Fernández A, Lain JM, Chabrera C et al (2015) Comparative long-term study of a large series of patients with invasive ductal carcinoma and invasive lobular carcinoma. Loco-regional recurrence, metastasis, and survival. Breast J 21:533–537. https://doi.org/10.1111/tbj.12455 CrossRefPubMed

15.

Braunstein LZ, Brock JE, Chen Y-H et al (2015) Invasive lobular carcinoma of the breast: local recurrence after breast-conserving therapy by subtype approximation and surgical margin. Breast Cancer Res Treat 149:555–564. https://doi.org/10.1007/s10549-015-3273-y CrossRefPubMed

16.

Caldarella A, Buzzoni C, Crocetti E et al (2013) Invasive breast cancer: a significant correlation between histological types and molecular subgroups. J Cancer Res Clin Oncol 139:617–623. https://doi.org/10.1007/s00432-012-1365-1 CrossRefPubMed

17.

Azim HA, Malek RA, Azim HA (2014) Pathological features and prognosis of lobular carcinoma in Egyptian breast cancer patients. Women’s Health 10:511–518. https://doi.org/10.2217/whe.14.48 CrossRefPubMed

18.

Beaber EF, Holt VL, et al (2009) Reproductive factors, age at maximum height, and risk of three histologic types of breast cancer. Cancer Epidermiol Prev Biomark 17:3427–3434. https://doi.org/10.1158/1055-9965.EPI-08-0641.Reproductive CrossRef

19.

Li CI, Daling JR, Malone KE, Bernstein L, et al (2006) Relationship between established breast cancer risk factors and risk of seven different histologic types of invasive breast cancer. Cancer Epidemiol Biomark Prev 15:946–954. https://doi.org/10.1158/1055-9965.EPI-05-0881 CrossRef

20.

Li C, Littman A, White E (2007) Relationship between age maximum height is attained, age at menarche, and age at first full-term birth and breast cancer risk. Cancer Epidemiol Biomarkers Prev 16:2144–2149. https://doi.org/10.1158/1055-9965.EPI-07-0242 CrossRefPubMed

21.

Nyante SJ, Gammon MD, Malone KE et al (2008) The association between oral contraceptive use and lobular and ductal breast cancer in young women. Int J Cancer 122:936–941. https://doi.org/10.1002/ijc.23163 CrossRefPubMed

22.

Reeves GK, Pirie K, Green J et al (2009) Reproductive factors and specific histological types of breast cancer: prospective study and meta-analysis. Br J Cancer 100:538–544. https://doi.org/10.1038/sj.bjc.6604853 CrossRefPubMedPubMedCentral

23.

Beral V, Bull D, Doll R, Peto R, Reeves G, van den Brandt PA, Golbohm RA (2012) Collaborative group on hormonal factors in breast cancer. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol 13:1141–1151. https://doi.org/10.1016/S1470-2045(12)70425-4 CrossRef

24.

Reeves GK, Beral V, Green J et al (2006) Hormonal therapy for menopause and breast-cancer risk by histological type: a cohort study and meta-analysis. Lancet Oncol 7:910–918. https://doi.org/10.1016/S1470-2045(06)70911-1 CrossRefPubMed

25.

Nyante SJ, Dallal CM, Gierach GL et al (2013) Risk factors for specific histopathological types of postmenopausal breast cancer in the NIH-AARP diet and health study. Am J Epidemiol 178:359–371. https://doi.org/10.1093/aje/kws471 CrossRefPubMedPubMedCentral

26.

Phipps AI, Li CI, Kerlikowske K et al (2010) Risk factors for ductal, lobular, and mixed ductal-lobular breast cancer in a screening population. Cancer Epidemiol Biomark Prev 19:1643–1654. https://doi.org/10.1158/1055-9965.EPI-10-0188 CrossRef

27.

Li CI, Daling JR, Haugen KL et al (2013) Use of menopausal hormone therapy and risk of ductal and lobular breast cancer among women 55–74 years of age. Breast Cancer Res 18:1199–1216. https://doi.org/10.1016/j.micinf.2011.07.011.Innate

28.

Kotsopoulos J, Chen WY, Gates MA et al (2010) Risk factors for ductal and lobular breast cancer: results from the nurses’ health study. Breast Cancer Res 12:R106. https://doi.org/10.1186/bcr2790 CrossRefPubMedPubMedCentral

29.

Calle EE, Feigelson HS, Hildebrand JS et al (2009) Postmenopausal hormone use and breast cancer associations differ by hormone regimen and histologic subtype. Cancer 115:936–945. https://doi.org/10.1002/cncr.24101 CrossRefPubMed

30.

Newcomb P, Trentham-Dietz A, Hampton J et al (2013) Late age at first full term birth is strongly associated with lobular breast cancer. Cancer 18:1199–1216. https://doi.org/10.1016/j.micinf.2011.07.011.Innate

31.

Newman B, Moorman PG, Millikan R et al (1995) The Carolina Breast Cancer Study: integrating population-based epidemiology and molecular biology. Breast Cancer Res Treat 35:51–60CrossRefPubMed

32.

Moorman PG, Millikan RC, Newman B (2001) Oral contraceptives and breast cancer among African-American women and white women. J Natl Med Assoc 93:329–334PubMedPubMedCentral

33.

Allott EH, Cohen SM, Geradts J et al (2016) Performance of three-biomarker immunohistochemistry for intrinsic breast cancer subtyping in the AMBER consortium. Cancer Epidemiol Biomarkers Prev 25:470–478. https://doi.org/10.1158/1055-9965.EPI-15-0874 CrossRefPubMed

34.

Spiegelman D, Hertzmark E (2005) Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol 162:199–200. https://doi.org/10.1093/aje/kwi188 CrossRefPubMed

35.

Begg CB, Zhang ZF (1994) Statistical analysis of molecular epidemiology studies employing case-series. Cancer Epidemiol Biomark Prev 3:173–175

36.

Li CI, Uribe DJ, Daling JR (2005) Clinical characteristics of different histologic types of breast cancer. Br J Cancer 93:1046–1052. https://doi.org/10.1038/sj.bjc.6602787 CrossRefPubMedPubMedCentral

37.

Bharat A, Gao F, Margenthaler JA (2009) Tumor characteristics and patient outcomes are similar between invasive lobular and mixed invasive ductal/lobular breast cancers but differ from pure invasive ductal breast cancers. Am J Surg 198:516–519. https://doi.org/10.1016/j.amjsurg.2009.06.005 CrossRefPubMed

38.

Chlebowski RT, Chen Z, Anderson GL et al (2005) Ethnicity and breast cancer: factors influencing differences in incidence and outcome. J Natl Cancer Inst 97:439–448. https://doi.org/10.1093/jnci/dji064 CrossRefPubMed

39.

Li CI, Malone KE, Daling JR (2002) Differences in breast cancer hormone receptor status and histology by race and ethnicity among women 50 years of age and older. Cancer Epidemiol Biomark Prev 11:601–607

40.

Rakha EA, Gill MS, El-Sayed ME et al (2009) The biological and clinical characteristics of breast carcinoma with mixed ductal and lobular morphology. Breast Cancer Res Treat 114:243–250. https://doi.org/10.1007/s10549-008-0007-4 CrossRefPubMed

41.

Zengel B, Yararbas U, Duran A et al (2015) Comparison of the clinicopathological features of invasive ductal, invasive lobular, and mixed (invasive ductal + invasive lobular) carcinoma of the breast. Breast Cancer 22:374–381. https://doi.org/10.1007/s12282-013-0489-8 CrossRefPubMed

42.

Arpino G, Bardou VJ, Clark GM, Elledge RM (2004) Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome. Breast Cancer Res 6:R149–R156. https://doi.org/10.1186/bcr767 CrossRef

43.

Pestalozzi BC, Zahrieh D, Mallon E et al (2008) Distinct clinical and prognostic features of infiltrating lobular carcinoma of the breast: combined results of 15 International Breast Cancer Study Group clinical trials. J Clin Oncol 26:3006–3014. https://doi.org/10.1200/JCO.2007.14.9336 CrossRefPubMed

44.

Lips EH, Mukhtar RA, Yau C et al (2012) Lobular histology and response to neoadjuvant chemotherapy in invasive breast cancer. Breast Cancer Res Treat 136:35–43. https://doi.org/10.1007/s10549-012-2233-z CrossRefPubMedPubMedCentral

45.

Cha YJ, Jung WH, Cho NH, Koo JS (2015) Expression of sarcosine metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma. Yonsei Med J 56:598–607. https://doi.org/10.3349/ymj.2015.56.3.598 CrossRefPubMedPubMedCentral

46.

Newcomer LM, Newcomb PA, Trentham-Dietz A et al (2003) Oral contraceptive use and risk of breast cancer by histologic type. Int J Cancer 106:961–964. https://doi.org/10.1002/ijc.11307 CrossRefPubMed

47.

Li CI, Malone KE, Porter PL et al (2003) Reproductive and anthropometric factors in relation to the risk of lobular and ductal breast carcinoma among women 65–79 years of age. Int J Cancer 107:647–651. https://doi.org/10.1002/ijc.11465 CrossRefPubMed

48.

Ursin G, Bernstein L, Lord SJ et al (2005) Reproductive factors and subtypes of breast cancer defined by hormone receptor and histology. Br J Cancer 93:364–371. https://doi.org/10.1038/sj.bjc.6602712 CrossRefPubMedPubMedCentral

49.

Kogan MD, Singh GK, Dee DL et al (2008) Multivariate analysis of state variation in breastfeeding rates in the United States. Am J Public Health 98:1872–1880. https://doi.org/10.2105/AJPH.2007.127118 CrossRefPubMedPubMedCentral

50.

Longacre TA, Ennis M, Quenneville LA et al (2006) Interobserver agreement and reproducibility in classification of invasive breast carcinoma: an NCI breast cancer family registry study. Mod Pathol 19:195–207. https://doi.org/10.1038/modpathol.3800496 CrossRefPubMed

Titel: Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study
verfasst von: Lindsay A. Williams
Hazel B. Nichols
Katherine A. Hoadley
Chiu Kit Tse
Joseph Geradts
Mary Elizabeth Bell
Charles M. Perou
Michael I. Love
Andrew F. Olshan
Melissa A. Troester
Publikationsdatum: 09.11.2017
Verlag: Springer International Publishing
Erschienen in: Cancer Causes & Control / Ausgabe 1/2018
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-017-0977-9

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study

Abstract

Background

Methods

Results

Conclusions

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2018

Plasma lipopolysaccharide-binding protein and colorectal cancer risk: a nested case–control study in the Multiethnic Cohort

Characterizing the neighborhood obesogenic environment in the Multiethnic Cohort: a multi-level infrastructure for cancer health disparities research

Prostate cancer screening by prostate-specific antigen (PSA); a relevant approach for the small population of the Cayman Islands

Early-onset baldness and the risk of aggressive prostate cancer: findings from a case–control study

Factors related to longitudinal adherence in colorectal cancer screening: qualitative research findings

Uptake of HPV testing and extended cervical cancer screening intervals following cytology alone and Pap/HPV cotesting in women aged 30–65 years

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie