nach oben

European Journal of Epidemiology

Erschienen in:

01.12.2013 | REVIEW

Physical activity, diabetes, and risk of thyroid cancer: a systematic review and meta-analysis

verfasst von: Daniela Schmid, Gundula Behrens, Carmen Jochem, Marlen Keimling, Michael Leitzmann

Erschienen in: European Journal of Epidemiology | Ausgabe 12/2013

Einloggen, um Zugang zu erhalten

Abstract

Thyroid cancer incidence has been increasing more rapidly over time than the occurrence of cancers of other sites, and interest in potential adverse relations of diabetes and lack of physical activity to thyroid cancer risk is accumulating. We conducted a systematic review and meta-analysis of published epidemiologic studies on the relations of physical activity and diabetes to thyroid cancer according to the Meta-analysis of Observational Studies in Epidemiology guidelines. Published studies were identified through a search in MEDLINE and EMBASE. Random-effects models were used to summarize thyroid cancer risk estimates comparing high versus low levels of physical activity, and separately, comparing individuals with diabetes versus those without diabetes. Meta-regression analyses were performed to evaluate potential effect modification by study design and thyroid cancer risk factors. Information was extracted from seven studies of physical activity and thyroid cancer and from six studies of diabetes and thyroid cancer. The number of individuals from studies on physical activity was 939,305 (yielding 2,250 incident thyroid cancer cases) and from studies on diabetes it was 960,840 (yielding 1,230 cases). The summary relative risk (RR) estimate from cohort and case–control studies combined indicated no association between physical activity and thyroid cancer (summary RR 1.06, 95 % confidence interval (CI) 0.79–1.42). Subgroup-analyses revealed a significant positive association between physical activity and thyroid cancer in cohort studies (summary RR 1.28; 95 % CI 1.01–1.63), whereas the relation was suggestively inverse in case–control studies (summary RR 0.70; 95 % CI 0.48–1.03; p for heterogeneity = 0.005). Individuals with diabetes showed a borderline statistically significant increased risk of thyroid cancer compared with those without diabetes (summary RR 1.17; 95 % CI 0.99–1.39). The relations of physical activity and diabetes to thyroid cancer were not modified by sex, number of adjustment factors, and adjustments for adiposity, smoking, and study quality. In this comprehensive systematic review and meta-analysis, no significant association between physical activity and thyroid cancer was found. Diabetes showed a suggestive positive relation with risk of thyroid cancer.

Kilfoy BA, Devesa SS, Ward MH, Zhang YW, Rosenberg PS, Holford TR, et al. Gender is an age-specific effect modifier for papillary cancers of the thyroid gland. Cancer Epidemiol Biomar. 2009;18(4):1092–100. doi:10.1158/1055-9965.Epi-08-0976.CrossRef

Kent WD, Hall SF, Isotalo PA, Houlden RL, George RL, Groome PA. Increased incidence of differentiated thyroid carcinoma and detection of subclinical disease. CMAJ. 2007;177(11):1357–61. doi:10.1503/cmaj.061730.PubMedCrossRef

Centers for Disease Control and Prevention (CDC). Facts about physical activity. http://www.cdc.gov/physicalactivity/data/facts.html. Accessed 16 Mar 2013.

King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998;21(9):1414–31.PubMedCrossRef

Zhao ZG, Guo XG, Ba CX, Wang W, Yang YY, Wang J, et al. Overweight, obesity and thyroid cancer risk: a meta-analysis of cohort studies. J Int Med Res. 2012;40(6):2041–50.PubMedCrossRef

Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569–78. doi:10.1016/S0140-6736(08)60269-X.PubMedCrossRef

Kitahara CM, Platz EA, Freeman LE, Hsing AW, Linet MS, Park Y, et al. Obesity and thyroid cancer risk among U.S. men and women: a pooled analysis of five prospective studies. Cancer Epidemiol Biomarkers Prev. 2011;20(3):464–72. doi:10.1158/1055-9965.EPI-10-1220.PubMedCrossRef

Kolonel LN, Hankin JH, Wilkens LR, Fukunaga FH, Hinds MW. An epidemiologic study of thyroid cancer in Hawaii. Cancer Causes Control. 1990;1(3):223–34.PubMedCrossRef

Lee SM, Kwak KH. Risk factors and a predictive model for thyroid cancer in Korean women. Cancer Nurs. 2010;33(4):310–9. doi:10.1097/NCC.0b013e3181cd2844.PubMedCrossRef

10.

Rossing MA, Remler R, Voigt LF, Wicklund KG, Daling JR. Recreational physical activity and risk of papillary thyroid cancer (United States). Cancer Causes Control. 2001;12(10):881–5.PubMedCrossRef

11.

Kitahara CM, Platz EA, Beane Freeman LE, Black A, Hsing AW, Linet MS, et al. Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies. Cancer Causes Control. 2012. doi:10.1007/s10552-012-9896-y.

12.

Kabat GC, Kim MY, Thomson CA, Luo J, Wactawski-Wende J, Rohan TE. Anthropometric factors and physical activity and risk of thyroid cancer in postmenopausal women. Cancer Causes Control. 2012;23(3):421–30. doi:10.1007/s10552-011-9890-9.PubMedCrossRef

13.

Robsahm TE, Hestvik UE, Veierod MB, Fagerlie A, Nystad W, Engebretsen L, et al. Cancer risk in Norwegian world class athletes. Cancer Causes Control. 2010;21(10):1711–9. doi:10.1007/s10552-010-9600-z.PubMedCrossRef

14.

Cash SW, Ma H, Horn-Ross PL, Reynolds P, Canchola AJ, Sullivan-Halley J, et al. Recreational physical activity and risk of papillary thyroid cancer among women in the California Teachers Study. Cancer Epidemiol. 2013;37(1):46–53. doi:10.1016/j.canep.2012.09.003.PubMedCrossRef

15.

Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, Tsugane S. Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch Intern Med. 2006;166(17):1871–7. doi:10.1001/archinte.166.17.1871.PubMedCrossRef

16.

Wideroff L, Gridley G, Mellemkjaer L, Chow WH, Linet M, Keehn S, et al. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst. 1997;89(18):1360–5.PubMedCrossRef

17.

Chodick G, Heymann AD, Rosenmann L, Green MS, Flash S, Porath A, et al. Diabetes and risk of incident cancer: a large population-based cohort study in Israel. Cancer Causes Control. 2010;21(6):879–87. doi:10.1007/s10552-010-9515-8.PubMedCrossRef

18.

Adami HO, McLaughlin J, Ekbom A, Berne C, Silverman D, Hacker D, et al. Cancer risk in patients with diabetes mellitus. Cancer Causes Control. 1991;2(5):307–14.PubMedCrossRef

19.

Kuriki K, Hirose K, Tajima K. Diabetes and cancer risk for all and specific sites among Japanese men and women. Eur J Cancer Prev Off J Eur Cancer Prev Org. 2007;16(1):83–9. doi:10.1097/01.cej.0000228404.37858.40.CrossRef

20.

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA, J Am Med Assoc. 2000;283(15):2008–12.CrossRef

21.

Wells SB, O’Connell D, Peterson J, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 16 Mar 2013.

22.

Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58. doi:10.1002/sim.1186.PubMedCrossRef

23.

Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.PubMedCrossRef

24.

Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.PubMedCrossRef

25.

Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36(3):1–48.

26.

Leitzmann MF, Brenner A, Moore SC, Koebnick C, Park Y, Hollenbeck A, et al. Prospective study of body mass index, physical activity and thyroid cancer. Int J Cancer. 2010;126(12):2947–56. doi:10.1002/ijc.24913.PubMed

27.

Meinhold CL, Ron E, Schonfeld SJ, Alexander BH, Freedman DM, Linet MS, et al. Nonradiation risk factors for thyroid cancer in the US Radiologic Technologists Study. Am J Epidemiol. 2010;171(2):242–52. doi:10.1093/aje/kwp354kwp354.PubMedCrossRef

28.

Marcello MA, Sampaio AC, Geloneze B, Vasques AC, Assumpcao LV, Ward LS. Obesity and excess protein and carbohydrate consumption are risk factors for thyroid cancer. Nutr Cancer. 2012;64(8):1190–5. doi:10.1080/01635581.2012.721154.PubMedCrossRef

29.

Aschebrook-Kilfoy B, Sabra MM, Brenner A, Moore SC, Ron E, Schatzkin A, et al. Diabetes and thyroid cancer risk in the National Institutes of Health-AARP Diet and Health Study. Thyroid Off J Am Thyroid Assoc. 2011;21(9):957–63. doi:10.1089/thy.2010.0396.CrossRef

30.

Tseng CH. Thyroid cancer risk is not increased in diabetic patients. PLoS ONE. 2012;7(12):e53096. doi:10.1371/journal.pone.0053096.PubMedCrossRef

31.

Chiou WK, Huang BY, Chou WY, Weng HF, Lin JD. Incidences of cancers in diabetic and non-diabetic hospitalized adult patients in Taiwan. Asian Pac J Cancer Prev APJCP. 2011;12(6):1577–81.

32.

Lee MY, Lin KD, Hsiao PJ, Shin SJ. The association of diabetes mellitus with liver, colon, lung, and prostate cancer is independent of hypertension, hyperlipidemia, and gout in Taiwanese patients. Metabolism. 2012;61(2):242–9. doi:10.1016/j.metabol.2011.06.020.PubMedCrossRef

33.

Ismail I, Keating SE, Baker MK, Johnson NA. A systematic review and meta-analysis of the effect of aerobic vs. resistance exercise training on visceral fat. Obes Rev. 2012;13(1):68–91. doi:10.1111/j.1467-789X.2011.00931.x.PubMedCrossRef

34.

Shih SR, Chiu WY, Chang TC, Tseng CH. Diabetes and thyroid cancer risk: literature review. Exp Diabetes Res. 2012;2012:578285. doi:10.1155/2012/578285.PubMedCrossRef

35.

La Vecchia C, Ron E, Franceschi S, Dal Maso L, Mark SD, Chatenoud L, et al. A pooled analysis of case-control studies of thyroid cancer. III. Oral contraceptives, menopausal replacement therapy and other female hormones. Cancer Causes Control. 1999;10(2):157–66.PubMedCrossRef

36.

Mitsiades N, Pazaitou-Panayiotou K, Aronis KN, Moon HS, Chamberland JP, Liu X, et al. Circulating adiponectin is inversely associated with risk of thyroid cancer: in vivo and in vitro studies. J Clin Endocrinol Metab. 2011;96(12):E2023–8. doi:10.1210/jc.2010-1908jc.2010-1908.PubMedCrossRef

37.

Sigurdson AJ, Hauptmann M, Alexander BH, Doody MM, Thomas CB, Struewing JP, et al. DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals. Mutat Res. 2005;586(2):173–88. doi:10.1016/j.mrgentox.2005.07.001.PubMedCrossRef

38.

Sato Y, Nanri H, Ohta M, Kasai H, Ikeda M. Increase of human MTH1 and decrease of 8-hydroxydeoxyguanosine in leukocyte DNA by acute and chronic exercise in healthy male subjects. Biochem Biophys Res Commun. 2003;305(2):333–8.PubMedCrossRef

39.

Rundle A. Molecular epidemiology of physical activity and cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(1):227–36.PubMed

40.

Ludlow AT, Zimmerman JB, Witkowski S, Hearn JW, Hatfield BD, Roth SM. Relationship between physical activity level, telomere length, and telomerase activity. Med Sci Sports Exerc. 2008;40(10):1764–71. doi:10.1249/MSS.0b013e31817c92aa.PubMedCrossRef

41.

Ivanov MK, Akushevich I, Gorski AI, Korelo AM, Kravchenko JS, Maksioutov MA, Tsyb AF. Risk of thyroid cancer after irradiation in children and adults. Curr Oncol. 2005;12(2):55–64.

42.

Wang C, Wang X, Gong G, Ben Q, Qiu W, Chen Y, et al. Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies. Int J Cancer. 2012;130(7):1639–48. doi:10.1002/ijc.26165.PubMedCrossRef

43.

Ben Q, Xu M, Ning X, Liu J, Hong S, Huang W, et al. Diabetes mellitus and risk of pancreatic cancer: a meta-analysis of cohort studies. Eur J Cancer. 2011;47(13):1928–37. doi:10.1016/j.ejca.2011.03.003.PubMedCrossRef

44.

Friberg E, Orsini N, Mantzoros CS, Wolk A. Diabetes mellitus and risk of endometrial cancer: a meta-analysis. Diabetologia. 2007;50(7):1365–74. doi:10.1007/s00125-007-0681-5.PubMedCrossRef

45.

Deng L, Gui Z, Zhao L, Wang J, Shen L. Diabetes mellitus and the incidence of colorectal cancer: an updated systematic review and meta-analysis. Dig Dis Sci. 2012;57(6):1576–85. doi:10.1007/s10620-012-2055-1.PubMedCrossRef

46.

Liao S, Li J, Wei W, Wang L, Zhang Y, Wang C, et al. Association between diabetes mellitus and breast cancer risk: a meta-analysis of the literature. Asian Pac J Cancer Prev APJCP. 2011;12(4):1061–5.

47.

Larsson SC, Orsini N, Brismar K, Wolk A. Diabetes mellitus and risk of bladder cancer: a meta-analysis. Diabetologia. 2006;49(12):2819–23. doi:10.1007/s00125-006-0468-0.PubMedCrossRef

48.

Lee JY, Jeon I, Lee JM, Yoon JM, Park SM. Diabetes mellitus as an independent risk factor for lung cancer: a meta-analysis of observational studies. Eur J Cancer. 2013;49(10):2411–23. doi:10.1016/j.ejca.2013.02.025.PubMedCrossRef

49.

Castillo JJ, Mull N, Reagan JL, Nemr S, Mitri J. Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies. Blood. 2012;119(21):4845–50. doi:10.1182/blood-2011-06-362830.PubMedCrossRef

50.

Giovannucci E, Harlan DM, Archer MC, Bergenstal RM, Gapstur SM, Habel LA, et al. Diabetes and cancer: a consensus report. Diabetes Care. 2010;33(7):1674–85. doi:10.2337/dc10-0666.PubMedCrossRef

51.

Gallagher EJ, LeRoith D. Diabetes, cancer, and metformin: connections of metabolism and cell proliferation. Ann N Y Acad Sci. 2011;1243:54–68. doi:10.1111/j.1749-6632.2011.06285.x.PubMedCrossRef

52.

Thakkar B, Aronis KN, Vamvini MT, Shields K, Mantzoros CS. Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-analysis using primary data of published studies. Metabolism. 2013;62(7):922–34. doi:10.1016/j.metabol.2013.01.014.PubMedCrossRef

53.

Soranna D, Scotti L, Zambon A, Bosetti C, Grassi G, Catapano A, et al. Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis. Oncologist. 2012;17(6):813–22. doi:10.1634/theoncologist.2011-0462.PubMedCrossRef

54.

Habib SL, Rojna M. Diabetes and risk of cancer. ISRN Oncol. 2013;2013:583786. doi:10.1155/2013/583786.PubMed

55.

Okura Y, Urban LH, Mahoney DW, Jacobsen SJ, Rodeheffer RJ. Agreement between self-report questionnaires and medical record data was substantial for diabetes, hypertension, myocardial infarction and stroke but not for heart failure. J Clin Epidemiol. 2004;57(10):1096–103. doi:10.1016/j.jclinepi.2004.04.005.PubMedCrossRef

56.

Tseng CH. Diabetes and thyroid cancer mortality: a 12-year prospective follow-up of Taiwanese. Eur J Clin Invest. 2013;43(6):595–601. doi:10.1111/eci.12086.PubMedCrossRef

Titel: Physical activity, diabetes, and risk of thyroid cancer: a systematic review and meta-analysis
verfasst von: Daniela Schmid
Gundula Behrens
Carmen Jochem
Marlen Keimling
Michael Leitzmann
Publikationsdatum: 01.12.2013
Verlag: Springer Netherlands
Erschienen in: European Journal of Epidemiology / Ausgabe 12/2013
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-013-9865-0

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2013

Unemployment and stillbirth risk among foreign-born and Spanish pregnant women in Spain, 2007–2010: a multilevel analysis study

A note of thanks

Education influences the role of genetics in myopia

The researcher and the consultant: a dialogue on null hypothesis significance testing

Long-term mortality risk by cause of death in newly diagnosed patients with epilepsy in Finland: a nationwide register-based study

The effect of the Chinese Cultural Revolution and Great Leap Forward on the prevalence of myopia