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Erschienen in: Journal of Assisted Reproduction and Genetics 7/2008

01.07.2008 | Assisted Reproduction

Viability of frozen-thawed human embryos with one–two blastomeres lysis

verfasst von: Xiaoying Zheng, Ping Liu, Guian Chen, Jie Qiao, Yuqi Wu, Ming Fan

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 7/2008

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Abstract

Objective

To assess the impact of one–two blastomeres lysis on the viability of thawed day 3 human embryos.

Methods

A retrospective analysis was performed on 248 frozen-thawed embryo replacement cycles in which all embryos were frozen at day 3 at the seven–eight cell stage with ≤10% fragmentation.

Results

Outcomes of transfer cycles with fully intact embryos (intact group) were compared with those in which all transferred embryos have lost one–two blastomeres (damage group). Comparable pregnancy rates (38.46% vs 38.64%), birth rates (34.62% vs 36.36%) and implantation rates (26.31% vs 26.25%) were obtained in intact and damage groups. These results were also not significantly different from mixed transfer cycles in which one intact embryo and one damaged embryo were transferred together.

Conclusion

The developmental potential of partially damaged cryopreserved human embryos with less than 25% cells loss is comparable to that of fully intact embryos. Presence of one–two lysed blastomeres in the thawed day 3 embryo does not appear to have a negative influence on the further development of the sibling intact cells.
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Metadaten
Titel
Viability of frozen-thawed human embryos with one–two blastomeres lysis
verfasst von
Xiaoying Zheng
Ping Liu
Guian Chen
Jie Qiao
Yuqi Wu
Ming Fan
Publikationsdatum
01.07.2008
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 7/2008
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-008-9224-3

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