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Erschienen in: Journal of Assisted Reproduction and Genetics 3/2012

01.03.2012 | ASSISTED REPRODUCTION TECHNOLOGIES

Pregnancy outcomes in oocyte donation recipients: vaginal gel versus intramuscular injection progesterone replacement

verfasst von: Brian M. Berger, James A. Phillips

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 3/2012

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Abstract

Purpose

Compare outcomes with vaginal gel versus intramuscular progesterone replacement in donor oocyte recipients.

Methods

A single-center retrospective analysis (January 2004–December 2006) evaluated pregnancy outcomes (serum human chorionic gonadotropin, implantation, clinical pregnancy, delivery, total pregnancy loss rates) for 225 recipients of embryos from donor (aged <32 years) oocytes. Vaginal progesterone gel (Crinone® 8%; 90 mg twice daily; n = 105) or intramuscular progesterone (50 mg once daily; n = 120) was started the afternoon of oocyte retrieval and continued until a negative pregnancy test or 10 weeks’ gestation.

Results

There were no statistically significant differences between groups for the five pregnancy outcomes; numerical results favored vaginal progesterone in all cases. Confidence intervals showed vaginal gel was within, or <1% from, a noninferiority limit of 10% versus intramuscular progesterone for four of five pregnancy outcomes.

Conclusions

Pregnancy outcomes were comparable for progesterone replacement with vaginal gel and intramuscular progesterone in an oocyte donation program.
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Metadaten
Titel
Pregnancy outcomes in oocyte donation recipients: vaginal gel versus intramuscular injection progesterone replacement
verfasst von
Brian M. Berger
James A. Phillips
Publikationsdatum
01.03.2012
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 3/2012
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-011-9691-9

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