nach oben

Journal of Assisted Reproduction and Genetics

Erschienen in:

01.02.2013

Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction

verfasst von: Dong Zi Yang, Wan Yang, Yu Li, Zuanyu He

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 2/2013

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To highlight recent progress in understanding the pattern of follicular wave emergence of human menstrual cycle, providing a brief overview of the new options for human ovarian stimulation and oocyte retrieval by making full use of follicular physiological waves of the patients either with normal or abnormal ovarian reserve.

Methods

Literature review and editorial commentary.

Results

There has been increasing evidence to suggest that multiple (two or three) antral follicular waves are recruited during human menstrual cycle. The treatment regimens designed based on the theory of follicular waves, to promote increased success with assisted reproduction technology (ART) and fertility preservation have been reported. These new options for human ovarian stimulation and oocyte retrieval by making full use of follicular waves of the patients either with normal or abnormal ovarian reserve lead to new thinking about the standard protocols in ART and challenge the traditional theory that a single wave of antral follicles grows only during the follicular phase of the menstrual cycle.

Conclusions

The understanding of human ovarian folliculogenesis may have profound implications in ART and fertility preservation. Further studies are needed to evaluate the optimal regimens in ART based on the theory of follicular waves and to identify non-invasive markers for predicting the outcome and the potential utilities of follicles obtained from anovulatory follicular waves in ART.

Hackeloer BJ, Fleming R, Robinson HP, Adam AH, Coutts JRT. Correlation of ultrasonic and endocrinologic assessment of human follicular development. Amer J Obstet Gynecol. 1979;135:122–8.

Chikazawa K, Araki S, Tamada T. Morphological and endocrinological studies on follicular development during the human menstrual cycle. J Clin Endocrinol Metab. 1986;62:305–13.PubMedCrossRef

Mihm M, Evans AC. Mechanisms for dominant follicle selection in monovulatory species: a comparison of morphological, endocrine and intraovarian events in cows, mares and women. Reprod Dom Anim. 2008;43 Suppl 2:48–56.CrossRef

Andreotti RF, Thompson GH, Janowitz W, Shapiro AG, Zusmer NR. Endovaginal and transabdominal sonography of ovarian follicles. J Ultrasound Med. 1989;8:555–60.PubMed

O’herlihy C. Monitoring ovarian follicular development with real-time ultrasound. Br J Obstet Gynaecol. 1980;87:613–8.PubMedCrossRef

Schipper I, Hop WCJ, Fauser BCJM. The follicle-stimulating hormone (FSH) threshold/window concept examined by different interventions with exogenous FSH during the follicular phase of the normal menstrual cycle: duration, rather than magnitude, of FSH increase affects follicle develop ment. J Clin Endocrinol Metab. 1998;83:1292.PubMedCrossRef

Pache T, Wladimiroff J, Dejong F, Hop W, Fauser B. Growth patterns of nondominant ovarian follicles during the normal menstrual cycle. Fertil Steril. 1990;54:638–42.PubMed

Baerwald A, Adams G, Pierson R. Characteristics of ovarian follicular wave dynamics in women. Biol Reprod. 2003;69:1023–31.PubMedCrossRef

Baerwald A, Adams G, Pierson R. A new model for ovarian follicular development during the human menstrual cycle. Fertil Steril. 2003;80:116–22.PubMedCrossRef

10.

Craig J, Orisaka M, Wang H, Orisaka S, Thompson W, Zhu C, et al. Gonadotropin and intra-ovarian signals regulating follicle development and atresia: the delicate balance between life and death. Front Biosci. 2007;12:3628–39.PubMedCrossRef

11.

Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA. A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod. 2008;23:699–708.PubMedCrossRef

12.

Gougeon A. Human ovarian follicular development: from activation of resting follicles to preovulatory maturation. Ann Endocrinol. 2010;71:132–43.CrossRef

13.

Macklon NS, Fauser BCJ. Regulation of follicle development and novel approaches to ovarian stimulation for IVF. Hum Reprod Update. 2000;6:307–12.CrossRef

14.

Maheshwari A, Gibreel A, Siristatidis CS, Bhattacharya S. Gonadotrophin-releasing hormone agonist protocols for pituitary suppression in assisted reproduction. Cochrane Database Syst Rev. 2011;10:CD006919.

15.

Ginther OJ, Gastal EL, Gastal MO, Bergfelt DR, Baerwald AR, Pierson RA. Comparative study of the dynamics of follicular waves in mares and women. Biol Reprod. 2004;71:1195–201.PubMedCrossRef

16.

Adams GP, Jaiswal R, Singh J, Malhi P. Progress in understanding ovarian follicular dynamics in cattle. Theriogenology. 2008;69:72–80.PubMedCrossRef

17.

Adams GP, Singha J, Baerwald AR. Large animal models for the study of ovarian follicular dynamics in women. Theriogenology. 2012; doi:10.1016/j.theriogenology.2012.04.010

18.

Miro F, Aspinall LJ. The onset of the initial rise in follicle-stimulating hormone during the human menstrual cycle. Hum Reprod. 2005;20:96–100.PubMedCrossRef

19.

Adams GP, Pierson RA. Bovine model for study of ovarian follicular dynamics in humans. Theriogenology. 1995;43:113–20.CrossRef

20.

Jaiswal RS, Singh J, Adams GP. Developmental pattern of small antral follicles in the bovine ovary. Biol Reprod. 2004;71:1244–51.PubMedCrossRef

21.

Jaiswal R, Singh J, Marshall L, Adams G. Repeatability of 2- and 3- wave patterns during the interovulatory interval in cattle. Theriogenology. 2009;72:81–90.PubMedCrossRef

22.

Mccorkell R, Woodbury M, Adams GP. Ovarian follicular and luteal dynamics in wapiti during the estrous cycle. Theriogenology. 2006;65:540–56.PubMedCrossRef

23.

Bishop CV, Sparman ML, Stanley JE, Bahar A, Zelinski MB, Stouffer RL. Evaluation of antral follicle growth in the macaque ovary during the menstrual cycle and controlled ovarian stimulation by high-resolution ultrasonography. Amer J Primatol. 2009;71:384–92.CrossRef

24.

Malhi PS, Adams GP, Jaswant S. Bovine model for the study of reproductive aging in women: follicular, luteal, and endocrine characteristics. Biol Reprod. 2005;73:45–53.PubMedCrossRef

25.

Van Santbrink E, Hop W, Dessel TV, Jong FD, Fauser B. Decremental follicle-stimulating hormone and dominant follicle development during the normal menstrual cycle. Fertil Steril. 1995;64:37–43.PubMed

26.

Fanchin R, Salomon L, Castelo-Branco A, Olivennes F, Frydman N, Frydman R. Luteal estradiol pretreatment coordinates follicular growth during controlled ovarian hyper-stimulation with GnRH antagonists. Hum Reprod. 2003;18:2698–703.PubMedCrossRef

27.

Frattarelli JL, Hill MJ, McWilliams GD, Miller KA, Bergh PA, Scott Jr RT. A luteal estradiol protocol for expected poor-responders improves embryo number and quality. Fertil Steril. 2008;89:1118–22.PubMedCrossRef

28.

Chang EM, Han JE, Won HJ, Kim YS, Yoon TK, Lee WS. Effect of estrogen priming through luteal phase and stimulation phase in poor responders in in-vitro fertilization. J Assist Reprod Genet. 2012;29:225–30.PubMedCrossRef

29.

Ata B, Zeng X, Son WY, Holzer H, Tan SL. Follicular synchronization using transdermal estradiol patch and GnRH antagonists in the luteal phase; does it increase oocyte yield in poor responders to gonadotropin stimulation for in vitro fertilization (IVF)? A comparative study with microdose flare-up protocol. Gynecol Endocrinol. 2011;27:876–9.PubMedCrossRef

30.

Kim CH, You RM, Kang HJ, Ahn JW, Jeon I, Lee JW, et al. GnRH antagonist multiple dose protocol with oral contraceptive pill pretreatment in poor responders undergoing IVF/ICSI. Clin Exp Reprod Med. 2011;38:228–33.PubMedCrossRef

31.

Fanchin R, Castelo-Branco A, Kadoch IJ, Hosny G, Bagirova M, Frydman R. Premenstrual administration of gonadotropin-releasing hormone antagonist coordinates early antral follicle sizes and sets up the basis for an innovative concept of controlled ovarian hyperstimulation. Fertil Steril. 2004;81:1554–9.PubMedCrossRef

32.

Elassar A, Mann JS, Engmann L, Nulsen J, Benadiva C. Luteal phase estradiol versus luteal phase estradiol and antagonist protocol for controlled ovarian stimulation before in vitro fertilization in poor responders. Fertil Steril. 2011;95:324–6.PubMedCrossRef

33.

Chang X, Wu J. Effects of luteal estradiol pre-treatment on the outcome of IVF in poor ovarian responders. Gynecol Endocrinol. 2012 Nov 30. [Epub ahead of print]

34.

Wang B, Sun HX, Liu JY, Hu YL, He FF. Appropriate prolongation of GnRH-a down-regulation improves the synchronism of follicular development. National J Androl Zhonghua Nan Ke Xue Za Zhi. 2011;17:1087–91.

35.

Weenen C, Laven JS, Von Bergh AR, Cranfield M, Groome NP, Visser JA, et al. Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod. 2004;10:77–83.PubMedCrossRef

36.

Durlinger AL, Gruijters MJ, Kramer P, Karels B, Ingraham HA, Nachtigal MW, et al. Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology. 2002;143:1076–84.PubMedCrossRef

37.

Nilsson E, Rogers N, Skinner MK. Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition. Reproduction. 2007;134:209–21.PubMedCrossRef

38.

Baerwald AR, Adams GP, Pierson RA. Ovarian antral folliculogenesis during the human menstrual cycle: a review. Hum Reprod Update. 2012;18:73–91.PubMedCrossRef

39.

Andersen CY, Schmidt KT, Kristensen SG, Rosendahl M, Byskov AG, Ernst E. Concentrations of AMH and Inhibin-B in relation to follicular diameter in normal human small antral follicles. Hum Reprod. 2010;25:1282–7.PubMedCrossRef

40.

McNatty KP, Hillier SG, Boogaard AMVD, Trimbos-Kemper TC, Reichert LK, Hall EVV. Follicular development during the luteal phase of the human menstrual cycle. J Clin Endocrinol Metab. 1983;56:1022–31.PubMedCrossRef

41.

Moulin J, Marszalek A, Gayet V, Blanchet V, Streuli I, Lafay M, Pont JC, Chapron C, De Ziegler D. In donor-egg IVF, COH outcome is not affected when progestindelivering IUDs (mirena) or implants (implanon) are left in place. Abst 27th Annual Meeting of ESHRE. 2011; O-127.

42.

Weissman A, Barash A, Shapiro H, Casper RF. Ovarian hyperstimulation following the sole administration of agonistic analogues of gonadotrophin releasing hormone. Hum Reprod. 1996;13:3421–4.CrossRef

43.

Vlahos NF, Choussein S, Economopoulos KP. Follicular development, acquisition of mature oocytes, and pregnancy after 2 weeks of leuprolide acetate administration during the midluteal phase. Fertil Steril. 2009;92:1170.e9–e11.CrossRef

44.

Pinto E, Pinelo S, Osório M, Ferreira C, Serra H, Pires I, et al. Outcomes from ovarian hyperstimulation following the sole administration of gonadotrophin-releasing hormone agonist in the context of in vitro fertilization: report of two cases and review of the literature. Gynecol Endocrinol. 2012;28:545–8.PubMedCrossRef

45.

Cha KY, Koo JJ, Ko JJ, Choi DH, Han SY, Yoon TK. Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program. Fertil Steril. 1991;55:109–13.PubMed

46.

Hwang JL, Lin YH, Tsai YL. Pregnancy after immature oocyte donation and intracytoplasmic sperm injection. Fertil Steril. 1997;68:1139–40.PubMedCrossRef

47.

Demirtas E, Elizur SE, Holzer H, Gidoni Y, Son WY, Chian RC, et al. Immature oocyte retrieval in the luteal phase to preserve fertility in cancer patients. Reprod Biomed Online. 2008;17:520–3.PubMedCrossRef

48.

Maman E, Meirow D, Brengauz M, Raanani H, Dor J, Hourvitz A. Luteal phase oocyte retrieval and in vitro maturation is an optional procedure for urgent fertility preservation. Fertil Steril. 2011;95:64–7.PubMedCrossRef

49.

Aerts JM, Bols PE. Ovarian follicular dynamics: a review with emphasis on the bovine species. Part I: folliculogenesis and pre-antral follicle development. Reprod Dom Anim. 2010;45:171–9.CrossRef

Titel: Progress in understanding human ovarian folliculogenesis and its implications in assisted reproduction
verfasst von: Dong Zi Yang
Wan Yang
Yu Li
Zuanyu He
Publikationsdatum: 01.02.2013
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 2/2013
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-013-9944-x

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Ambulantisierung: Erste Erfahrungen mit dem Hybrid-DRG

02.05.2024 DCK 2024 Kongressbericht

Die Hybrid-DRG-Verordnung soll dazu führen, dass mehr chirurgische Eingriffe ambulant durchgeführt werden, wie es in anderen Ländern schon länger üblich ist. Die gleiche Vergütung im ambulanten und stationären Sektor hatten Niedergelassene schon lange gefordert. Aber die Umsetzung bereitet ihnen doch Kopfzerbrechen.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Harninkontinenz: Netz-Op. erfordert über lange Zeit intensive Nachsorge

30.04.2024 Harninkontinenz Nachrichten

Frauen mit Belastungsinkontinenz oder Organprolaps sind nach einer Netz-Operation keineswegs beschwerdefrei. Vielmehr scheint die Krankheitslast weiterhin hoch zu sein, sogar höher als von harninkontinenten Frauen, die sich nicht haben operieren lassen.

Welche Übungen helfen gegen Diastase recti abdominis?

30.04.2024 Schwangerenvorsorge Nachrichten

Die Autorinnen und Autoren einer aktuellen Studie aus Griechenland sind sich einig, dass Bewegungstherapie, einschließlich Übungen zur Stärkung der Bauchmuskulatur und zur Stabilisierung des Rumpfes, eine Diastase recti abdominis postpartum wirksam reduzieren kann. Doch vieles ist noch nicht eindeutig belegt.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2013

The clinical ramifications of polycystic ovarian morphology in oocyte donors

Single thawed euploid embryo transfer improves IVF pregnancy, miscarriage, and multiple gestation outcomes and has similar implantation rates as egg donation

Positive association of Apolipoprotein E4 polymorphism with recurrent pregnancy loss in Iranian patients

A study of meiotic segregation in a fertile human population following ovarian stimulation with recombinant FSH-LH