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Journal of Interventional Cardiac Electrophysiology

Erschienen in:

01.11.2011

Asymmetric dimethylarginine concentration and recurrence of atrial tachyarrythmias after catheter ablation in patients with persistent atrial fibrillation

verfasst von: Li Yang, Qu Xiufen, Sun Shuqin, Yu Yang, Song Ying, Yu Yanwei, Feng Wei, Yin Dechun

Erschienen in: Journal of Interventional Cardiac Electrophysiology | Ausgabe 2/2011

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Abstract

Purpose

It has been reported that elevation of asymmetric dimethylarginine (ADMA) concentration is involved in atrial fibrillation (AF) process. The purpose of this study was to determine whether ADMA concentration is related to recurrences of AF after catheter ablation.

Methods

A total of one hundred and thirty-eight patients with persistent AF (49.91 ± 7.23 years), but without known heart disease, who underwent successful mapping and catheter ablation were included. Serum ADMA levels were measured 1 day before the catheter ablation.

Results

After a mean follow-up period of 285 days (range, 98–651 days), 80 (58%) patients underwent the AF recurrence. Comparing with no AF recurrence group, the serum ADMA concentration, left atrial diameter, and persistent duration of AF in patients with AF recurrence group were significantly increased. Left atrial diameter, persistent duration of AF, and the number of non-pulmonary vein ectopy ablation were increased when serum ADMA concentration was elevated. In addition, AF recurrences were significantly increased when serum ADMA concentration was elevated. A multivariable Cox regression analysis demonstrated that the elevated ADMA concentration [hazard ration (95% CI), 4.59 (1.81–11.62); P = 0.001], the left atrial diameter [1.35 (1.18–1.55), P < 0.001], and the number of non-pulmonary vein ectopy ablation [1.94 (1.18–3.18), P = 0.009] were independent factors associated with the AF recurrence after catheter ablation.

Conclusions

This study demonstrated that (1) serum ADMA concentrations were associated with non-PV ectopies and (2) increased serum ADMA concentrations were associated with higher rate of AF recurrence after catheter ablation in patients with persistent AF, supporting our hypothesis that ADMA might participate in the process of atrial remodeling.

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Titel: Asymmetric dimethylarginine concentration and recurrence of atrial tachyarrythmias after catheter ablation in patients with persistent atrial fibrillation
verfasst von: Li Yang
Qu Xiufen
Sun Shuqin
Yu Yang
Song Ying
Yu Yanwei
Feng Wei
Yin Dechun
Publikationsdatum: 01.11.2011
Verlag: Springer US
Erschienen in: Journal of Interventional Cardiac Electrophysiology / Ausgabe 2/2011
Print ISSN: 1383-875X
Elektronische ISSN: 1572-8595
DOI: https://doi.org/10.1007/s10840-011-9588-7

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