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Journal of Mammary Gland Biology and Neoplasia

Erschienen in:

01.09.2007

Hedgehog Signaling in Mammary Gland Development and Breast Cancer

verfasst von: Sarah Hatsell, Andra R. Frost

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 2-3/2007

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Abstract

The Hedgehog pathway is critical for many developmental processes, including the formation of several epidermal appendages. In the mammary gland strict regulation of the Hedgehog pathway is required for normal development. Alterations in Hedgehog signaling result in defects in both the embryonic and postnatal mammary gland. Activation of Hedgehog signaling either by mutation or misexpression of pathway members can lead to the development and/or progression of cancers in multiple organs. This review addresses the current understanding and controversies of Hedgehog signaling in mammary gland development and its potential role in promoting breast carcinogenesis and cancer progression.

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Titel: Hedgehog Signaling in Mammary Gland Development and Breast Cancer
verfasst von: Sarah Hatsell
Andra R. Frost
Publikationsdatum: 01.09.2007
Verlag: Springer US
Erschienen in: Journal of Mammary Gland Biology and Neoplasia / Ausgabe 2-3/2007
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-007-9048-2

Springer Medizin

Hedgehog Signaling in Mammary Gland Development and Breast Cancer

Abstract

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