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Journal of Mammary Gland Biology and Neoplasia
Erschienen in: Journal of Mammary Gland Biology and Neoplasia 3-4/2012

01.12.2012

Targeting the PI3K/Akt/mTOR Pathway for Breast Cancer Therapy

verfasst von: Justin Cidado, Ben Ho Park

Erschienen in: Journal of Mammary Gland Biology and Neoplasia | Ausgabe 3-4/2012

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Abstract

Recent advances in genetics and genomics have revealed new pathways that are aberrantly activated in many breast cancers. Chief among these genetic changes are somatic mutations and/or gains and losses of key genes within the phosphoinositide 3-kinase (PI3K) pathway. Since breast cancer cell growth and progression is often dependent upon activation of the PI3K pathway, there has been intense research interest in finding therapeutic agents that can selectively inhibit one or more constituents of this signaling cascade. Here we review key molecules involved with aberrant PI3K pathway activation in breast cancers and current efforts to target these components for therapeutic gain.
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Metadaten
Titel
Targeting the PI3K/Akt/mTOR Pathway for Breast Cancer Therapy
verfasst von
Justin Cidado
Ben Ho Park
Publikationsdatum
01.12.2012
Verlag
Springer US
Erschienen in
Journal of Mammary Gland Biology and Neoplasia / Ausgabe 3-4/2012
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI
https://doi.org/10.1007/s10911-012-9264-2

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