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Quality of Life Research

Erschienen in:

01.12.2010

I’m so tired: biological and genetic mechanisms of cancer-related fatigue

verfasst von: Andrea Barsevick, Marlene Frost, Aeilko Zwinderman, Per Hall, Michele Halyard, GENEQOL Consortium

Erschienen in: Quality of Life Research | Ausgabe 10/2010

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Abstract

Objective

The goal of this paper is to discuss cancer-related fatigue (CRF) and address issues related to the investigation into potential biological and genetic causal mechanisms. The objectives are to: (1) describe CRF as a component of quality of life (QOL); (2) address measurement issues that have slowed progress toward an understanding of mechanisms underlying this symptom; (3) review biological pathways and genetic approaches that have promise for the exploration of causal mechanisms of CRF; and (4) offer directions for future research.

Methods

Review, synthesis, and interpretation of the literature.

Results

Until recently, CRF and QOL have been understood primarily as subjective patient-reported experiences. With increased understanding of human genetics, theories and research are being expanded to incorporate biological and genetic understandings of these subjective experiences. Proposed biological and genetic mechanisms of CRF that have been examined include cytokine dysregulation, hypothalamic–pituitary–adrenal (HPA) axis dysfunction, five hydroxy tryptophan (5-HT) neurotransmitter dysregulation, circadian rhythm disruption, alterations in adenosine triphosphate (ATP) and muscle metabolism, and vagal afferent activation. Approaches to the study of genetic mechanisms have also been addressed including candidate genes, genome-wide scanning, and gene expression. Based on the review and synthesis of the literature, directions for future research are proposed.

Conclusions

Understanding the biological and genetic basis of CRF has the potential to contribute to a more complete understanding of the genetic determinants of QOL.

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Titel: I’m so tired: biological and genetic mechanisms of cancer-related fatigue
verfasst von: Andrea Barsevick
Marlene Frost
Aeilko Zwinderman
Per Hall
Michele Halyard
GENEQOL Consortium
Publikationsdatum: 01.12.2010
Verlag: Springer Netherlands
Erschienen in: Quality of Life Research / Ausgabe 10/2010
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-010-9757-7

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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