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09.09.2019 | Affective Disorder

Relationships between cognition, function, and quality of life among HIV+ Canadian men

verfasst von: Nancy E. Mayo, Marie-Josée Brouillette, Susan C. Scott, Marianne Harris, Fiona Smaill, Graham Smith, Réjean Thomas, Lesley K. Fellows, and investigators from the Positive Brain Health Now Study

Erschienen in: Quality of Life Research | Ausgabe 1/2020

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Abstract

Objective

To estimate the extent to which HIV-related variables, cognition, and other brain health factors interrelate with other HIV-associated symptoms to influence function, health perception, and QOL in older HIV+ men in Canada.

Design

Cross-sectional structural equation modelling (SEM) of data from the inaugural visit to the Positive Brain Health Now Cohort.

Setting

HIV clinics at 5 Canadian sites.

Subjects

707 men, age ≥ 35 years, HIV+ for at least one year, without clinically diagnosed dementia.

Main outcome measures

Five latent and 21 observed variables from the World Health Organization’s biopsychosocial model for functioning and disability and the Wilson–Cleary Model were analysed. SEM was used to link disease factors to symptoms, impairments, function, health perception, and QOL with a focus on cognition.

Results

QOL was explained directly by depression, social role, health perception, social support, and quality of the environment. Measured cognitive performance had direct effects on activity/function and indirect effects on participation, HP and QOL, acting through self-reported cognitive difficulties and meaningful activities.

Conclusion

The biopsychosocial model showed good fit, with RMSEA < 0.05. This is the first time the full model has been tested in HIV. All of the domains included in the model are theoretically amenable to intervention and many have evidence-based interventions that could be harnessed to improve QOL.

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Titel: Relationships between cognition, function, and quality of life among HIV+ Canadian men
verfasst von: Nancy E. Mayo
Marie-Josée Brouillette
Susan C. Scott
Marianne Harris
Fiona Smaill
Graham Smith
Réjean Thomas
Lesley K. Fellows
and investigators from the Positive Brain Health Now Study
Publikationsdatum: 09.09.2019
Verlag: Springer International Publishing
Schlagwörter: Affective Disorder
Human Immunodeficiency Virus
Affective Disorder
Erschienen in: Quality of Life Research / Ausgabe 1/2020
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-019-02291-w

Springer Medizin

Abstract

Objective

Design

Setting

Subjects

Main outcome measures

Results

Conclusion

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