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International Urology and Nephrology

Erschienen in:

01.03.2015 | Urology – Original Paper

Relationship between LSD1 expression and E-cadherin expression in prostate cancer

verfasst von: Min Wang, Xiuheng Liu, Guanjun Jiang, Hui Chen, Jia Guo, Xiaodong Weng

Erschienen in: International Urology and Nephrology | Ausgabe 3/2015

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Abstract

Purpose

To investigate the relationship between the expression of LSD1 and E-cadherin in prostate cancer and their prognostic significance.

Methods

The expression of LSD1 and E-cadherin in prostate cancer was detected using immunohistochemistry, and the relationship between the expressions of these two molecules was analyzed by correlation analysis. Furthermore, LNCap cell line was treated with Pargyline (an inhibitor of LSD1), and Western blot was used to analyze LSD1 and E-cadherin expression.

Results

LSD1 expression increased significantly in prostate cancer specimens compared with benign prostatic hyperplasia (P < 0.05). Further analysis testified that LSD1 expression was positively correlated with higher Gleason Score, distant metastases, and poor prognosis (P < 0.05). Nevertheless, E-cadherin expression decreased significantly in prostate cancer specimens compared with benign prostatic hyperplasia (P < 0.05) and was negatively correlated with higher Gleason Score, distant metastases (P < 0.05). Correlation analysis revealed that LSD1 expression was negatively correlated with E-cadherin expression in prostate cancer (rs = −0.486, P = 0.001). Positive LSD1 expression and negative E-cadherin expression were significantly correlated with high 2-year progression (occurrence of castration-resistant prostate cancer) rate and low 5-year survival rate (P < 0.05). Moreover, Pargyline inhibited activity of LSD1 and up-regulated E-cadherin expression.

Conclusion

High LSD1 expression combined with low E-cadherin expression might be predictors of prostate cancer progression and metastasis. Inhibition of LSD1 may be a potential therapeutic target for prevention of prostate cancer.

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Titel: Relationship between LSD1 expression and E-cadherin expression in prostate cancer
verfasst von: Min Wang
Xiuheng Liu
Guanjun Jiang
Hui Chen
Jia Guo
Xiaodong Weng
Publikationsdatum: 01.03.2015
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 3/2015
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-015-0915-2

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Relationship between LSD1 expression and E-cadherin expression in prostate cancer

Abstract

Purpose

Methods

Results

Conclusion

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