Skip to main content
Erschienen in: International Urology and Nephrology 5/2019

19.03.2019 | Nephrology - Editorial

Treating symptoms to improve the quality of life in patients on chronic hemodialysis

verfasst von: Maurizio Bossola, Gilda Pepe, Anna Picca, Riccardo Calvani, Emanuele Marzetti

Erschienen in: International Urology and Nephrology | Ausgabe 5/2019

Einloggen, um Zugang zu erhalten

Abstract

Health-related quality of life (HRQOL) in patients on chronic hemodialysis has not improved significantly in the last 20 years. This is largely due to their substantial symptom burden which is rarely assessed and treated in routine clinical practice. This is also consequence of the lack of an appropriate armamentarium for the treatments of such symptoms. Adequate studies on the causes and pathogenesis of the symptoms of hemodialysis patients are needed followed by high-quality studies on possible therapeutic pharmacological and non-pharmacological interventions. Patients on chronic hemodialysis deserve a better quality of life.
Literatur
1.
Zurück zum Zitat Gabbay E, Meyer KB, Griffith JL, Richardson MM, Miskulin DC (2010) Temporal trends in health-related quality of life among hemodialysis patients in the United States. Clin J Am Soc Nephrol 5:261–267CrossRefPubMedPubMedCentral Gabbay E, Meyer KB, Griffith JL, Richardson MM, Miskulin DC (2010) Temporal trends in health-related quality of life among hemodialysis patients in the United States. Clin J Am Soc Nephrol 5:261–267CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Mazairac AH, de Wit GA, Penne EL et al (2011) Changes in quality of life overtime—Dutch haemodialysis patients and general population compared. Nephrol Dial Transplant 26:1984–1989CrossRefPubMed Mazairac AH, de Wit GA, Penne EL et al (2011) Changes in quality of life overtime—Dutch haemodialysis patients and general population compared. Nephrol Dial Transplant 26:1984–1989CrossRefPubMed
3.
Zurück zum Zitat Lacson E Jr, Xu J, Lin SF, Dean SG, Lazarus JM, Hakim R (2009) Association between achievement of hemodialysis quality-of-care indicators and quality-of-life scores. Am J Kidney Dis 54:1098–1107CrossRefPubMed Lacson E Jr, Xu J, Lin SF, Dean SG, Lazarus JM, Hakim R (2009) Association between achievement of hemodialysis quality-of-care indicators and quality-of-life scores. Am J Kidney Dis 54:1098–1107CrossRefPubMed
4.
Zurück zum Zitat Diaz-Buxo JA, Lowrie EG, Lew NL, Zhang H, Lazarus JM (2000) Quality-of-life evaluation using short form 36: comparison in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis 35:293–300CrossRefPubMed Diaz-Buxo JA, Lowrie EG, Lew NL, Zhang H, Lazarus JM (2000) Quality-of-life evaluation using short form 36: comparison in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis 35:293–300CrossRefPubMed
5.
Zurück zum Zitat Lowrie EG, Curtin RB, LePain N, Schatell D (2003) Medical outcomes study short form-36: a consistent and powerful predictor of morbidity and mortality in dialysis patients. Am J Kidney Dis 41:1286–1292CrossRefPubMed Lowrie EG, Curtin RB, LePain N, Schatell D (2003) Medical outcomes study short form-36: a consistent and powerful predictor of morbidity and mortality in dialysis patients. Am J Kidney Dis 41:1286–1292CrossRefPubMed
6.
Zurück zum Zitat Merkus MP, Jager KJ, Dekker FW, de Haan RJ, Boeschoten EW, Krediet RT (1999) Physical symptoms and quality of life in patients on chronic dialysis: results of the netherlands cooperative study on adequacy of dialysis (NECOSAD). Nephrol Dial Transplant 14:1163–1170CrossRefPubMed Merkus MP, Jager KJ, Dekker FW, de Haan RJ, Boeschoten EW, Krediet RT (1999) Physical symptoms and quality of life in patients on chronic dialysis: results of the netherlands cooperative study on adequacy of dialysis (NECOSAD). Nephrol Dial Transplant 14:1163–1170CrossRefPubMed
7.
Zurück zum Zitat Bakewell AB, Higgins RM, Edmunds ME (2002) Quality of life in peritoneal dialysis patients: decline over time and association with clinical outcomes. Kidney Int 61:239–248CrossRefPubMed Bakewell AB, Higgins RM, Edmunds ME (2002) Quality of life in peritoneal dialysis patients: decline over time and association with clinical outcomes. Kidney Int 61:239–248CrossRefPubMed
8.
Zurück zum Zitat Wu AW, Fink NE, Marsh-Manzi JV et al (2004) Changes in quality of life during hemodialysis and peritoneal dialysis treatment: generic and disease specific measures. J Am Soc Nephrol 15:743–753CrossRefPubMed Wu AW, Fink NE, Marsh-Manzi JV et al (2004) Changes in quality of life during hemodialysis and peritoneal dialysis treatment: generic and disease specific measures. J Am Soc Nephrol 15:743–753CrossRefPubMed
9.
Zurück zum Zitat Garcia-Mendoza M, Valdés C, Ortega T, Rebollo P, Ortega F (2006) Differences in health-related quality of life between elderly and younger patients on hemodialysis. J Nephrol 19:808–818PubMed Garcia-Mendoza M, Valdés C, Ortega T, Rebollo P, Ortega F (2006) Differences in health-related quality of life between elderly and younger patients on hemodialysis. J Nephrol 19:808–818PubMed
10.
Zurück zum Zitat Unruh ML, Newman AB, Larive B et al (2008) The influence of age on changes in health-related quality of life over three years in a cohort undergoing hemodialysis. J Am Geriatr Soc 56:1608–1617CrossRefPubMedPubMedCentral Unruh ML, Newman AB, Larive B et al (2008) The influence of age on changes in health-related quality of life over three years in a cohort undergoing hemodialysis. J Am Geriatr Soc 56:1608–1617CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Santos PR, Daher EF, Silva GB Jr, Libório AB, Kerr LR (2009) Quality of life assessment among haemodialysis patients in a single centre: a 2-year follow-up. Qual Life Res 18:541–546CrossRefPubMed Santos PR, Daher EF, Silva GB Jr, Libório AB, Kerr LR (2009) Quality of life assessment among haemodialysis patients in a single centre: a 2-year follow-up. Qual Life Res 18:541–546CrossRefPubMed
12.
Zurück zum Zitat Broers NJ, Usvyat LA, Kooman JP et al (2015) Quality of life in dialysis patients: a retrospective cohort study. Nephron 130:105–112CrossRefPubMed Broers NJ, Usvyat LA, Kooman JP et al (2015) Quality of life in dialysis patients: a retrospective cohort study. Nephron 130:105–112CrossRefPubMed
13.
Zurück zum Zitat Perl J, Karaboyas A, Morgenstern H et al (2017) Association between changes in quality of life and mortality in hemodialysis patients: results from the DOPPS. Nephrol Dial Transplant 32:521–527CrossRefPubMed Perl J, Karaboyas A, Morgenstern H et al (2017) Association between changes in quality of life and mortality in hemodialysis patients: results from the DOPPS. Nephrol Dial Transplant 32:521–527CrossRefPubMed
14.
Zurück zum Zitat Liebman S, Li NC, Lacson E (2016) Change in quality of life and one-year mortality risk in maintenance dialysis patients. Qual Life Res 25:2295–2306CrossRefPubMed Liebman S, Li NC, Lacson E (2016) Change in quality of life and one-year mortality risk in maintenance dialysis patients. Qual Life Res 25:2295–2306CrossRefPubMed
15.
Zurück zum Zitat Belayev LY, Mor MK, Sevick MA et al (2015) Longitudinal associations of depressive symptoms and pain with quality of life in patients receiving chronic hemodialysis. Hemodial Int 19:216–224CrossRefPubMed Belayev LY, Mor MK, Sevick MA et al (2015) Longitudinal associations of depressive symptoms and pain with quality of life in patients receiving chronic hemodialysis. Hemodial Int 19:216–224CrossRefPubMed
16.
Zurück zum Zitat Murtagh FE, Addington-Hall J, Higginson IJ (2007) The prevalence of symptoms in end-stage renal disease: a systematic review. Adv Chronic Kidney Dis 14:82–99CrossRefPubMed Murtagh FE, Addington-Hall J, Higginson IJ (2007) The prevalence of symptoms in end-stage renal disease: a systematic review. Adv Chronic Kidney Dis 14:82–99CrossRefPubMed
17.
Zurück zum Zitat Lowney AC, Myles HT, Bristowe K et al (2015) Understanding what influences the health-related quality of life of hemodialysis patients: a collaborative study in England and Ireland. J Pain Symptom Manag 50:778–785CrossRef Lowney AC, Myles HT, Bristowe K et al (2015) Understanding what influences the health-related quality of life of hemodialysis patients: a collaborative study in England and Ireland. J Pain Symptom Manag 50:778–785CrossRef
18.
Zurück zum Zitat Weisbord SD, Fried LF, Arnold RM et al (2005) Prevalence, severity, and importance of physical and emotional symptoms in chronic hemodialysis patients. J Am Soc Nephrol 16:2487–2494CrossRefPubMed Weisbord SD, Fried LF, Arnold RM et al (2005) Prevalence, severity, and importance of physical and emotional symptoms in chronic hemodialysis patients. J Am Soc Nephrol 16:2487–2494CrossRefPubMed
19.
Zurück zum Zitat Abdel-Kader K, Unruh ML, Weisbord SD (2009) Symptom burden, depression, and quality of life in chronic and end-stage kidney disease. Clin J Am Soc Nephrol 4:1057–1064CrossRefPubMedPubMedCentral Abdel-Kader K, Unruh ML, Weisbord SD (2009) Symptom burden, depression, and quality of life in chronic and end-stage kidney disease. Clin J Am Soc Nephrol 4:1057–1064CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Thong MS, van Dijk S, Noordzij M et al (2009) Symptom clusters in incident dialysis patients: associations with clinical variables and quality of life. Nephrol Dial Transplant 24:225–230CrossRefPubMed Thong MS, van Dijk S, Noordzij M et al (2009) Symptom clusters in incident dialysis patients: associations with clinical variables and quality of life. Nephrol Dial Transplant 24:225–230CrossRefPubMed
21.
Zurück zum Zitat Yong DS, Kwok AO, Wong DM, Suen MH, Chen WT, Tse DM (2009) Symptom burden and quality of life in end-stage renal disease: a study of 179 patients on dialysis and palliative care. Palliat Med 23:111–119CrossRefPubMed Yong DS, Kwok AO, Wong DM, Suen MH, Chen WT, Tse DM (2009) Symptom burden and quality of life in end-stage renal disease: a study of 179 patients on dialysis and palliative care. Palliat Med 23:111–119CrossRefPubMed
22.
Zurück zum Zitat Davison SN, Jhangri GS, Johnson JA (2006) Cross-sectional validity of a modified edmonton symptom assessment system in dialysis patients: a simple assessment of symptom burden. Kidney Int 69:1621–1625CrossRefPubMed Davison SN, Jhangri GS, Johnson JA (2006) Cross-sectional validity of a modified edmonton symptom assessment system in dialysis patients: a simple assessment of symptom burden. Kidney Int 69:1621–1625CrossRefPubMed
23.
Zurück zum Zitat Weisbord SD, Fried LF, Unruh ML et al (2007) Associations of race with depression and symptoms in patients on maintenance haemodialysis. Nephrol Dial Transplant 22:203–208CrossRefPubMed Weisbord SD, Fried LF, Unruh ML et al (2007) Associations of race with depression and symptoms in patients on maintenance haemodialysis. Nephrol Dial Transplant 22:203–208CrossRefPubMed
24.
Zurück zum Zitat Weisbord SD, Bossola M, Fried LF et al (2008) Cultural comparison of symptoms in patients on maintenance hemodialysis. Hemodial Int 12:434–440CrossRefPubMed Weisbord SD, Bossola M, Fried LF et al (2008) Cultural comparison of symptoms in patients on maintenance hemodialysis. Hemodial Int 12:434–440CrossRefPubMed
25.
Zurück zum Zitat Claxton RN, Blackhall L, Weisbord SD, Holley JL (2010) Undertreatment of symptoms inpatients on maintenance hemodialysis. J Pain Symptom Manag 39:211–218CrossRef Claxton RN, Blackhall L, Weisbord SD, Holley JL (2010) Undertreatment of symptoms inpatients on maintenance hemodialysis. J Pain Symptom Manag 39:211–218CrossRef
26.
Zurück zum Zitat Weisbord SD, Fried LF, Mor MK et al (2007) Renal provider recognition of symptoms in patients on maintenance hemodialysis. Clin J Am Soc Nephrol 2:960–967CrossRefPubMed Weisbord SD, Fried LF, Mor MK et al (2007) Renal provider recognition of symptoms in patients on maintenance hemodialysis. Clin J Am Soc Nephrol 2:960–967CrossRefPubMed
27.
Zurück zum Zitat Raj R, Ahuja KD, Frandsen M, Jose M (2017) Symptoms and their recognition in adult haemodialysis patients: interactions with quality of life. Nephrology (Carlton) 22:228–233CrossRef Raj R, Ahuja KD, Frandsen M, Jose M (2017) Symptoms and their recognition in adult haemodialysis patients: interactions with quality of life. Nephrology (Carlton) 22:228–233CrossRef
28.
Zurück zum Zitat Lindner AV, Novak M, Bohra M, Mucsi I (2015) Insomnia in patients with chronic kidney disease. Semin Nephrol 35:359–372CrossRefPubMed Lindner AV, Novak M, Bohra M, Mucsi I (2015) Insomnia in patients with chronic kidney disease. Semin Nephrol 35:359–372CrossRefPubMed
30.
Zurück zum Zitat Bossola M, Tazza L. (2016) Postdialysis fatigue: a frequent and debilitating symptom. Semin Dial 29(3):222–227CrossRefPubMed Bossola M, Tazza L. (2016) Postdialysis fatigue: a frequent and debilitating symptom. Semin Dial 29(3):222–227CrossRefPubMed
31.
Zurück zum Zitat Bossola M, Vulpio C, Tazza L (2011) Fatigue in chronic dialysis patients. Semin Dial 24(5):550–555CrossRefPubMed Bossola M, Vulpio C, Tazza L (2011) Fatigue in chronic dialysis patients. Semin Dial 24(5):550–555CrossRefPubMed
32.
Zurück zum Zitat Artom M, Moss-Morris R, Caskey F, Chilcot J (2014) Fatigue in advanced kidney disease. Kidney Int 86:497–505CrossRefPubMed Artom M, Moss-Morris R, Caskey F, Chilcot J (2014) Fatigue in advanced kidney disease. Kidney Int 86:497–505CrossRefPubMed
33.
Zurück zum Zitat Bossola M, Di Stasio E, Giungi S, Rosa F, Tazza L (2015) Fatigue is associated with serum interleukin-6 levels and symptoms of depression in patients on chronic hemodialysis. J Pain Symptom Manag 49:578–585CrossRef Bossola M, Di Stasio E, Giungi S, Rosa F, Tazza L (2015) Fatigue is associated with serum interleukin-6 levels and symptoms of depression in patients on chronic hemodialysis. J Pain Symptom Manag 49:578–585CrossRef
34.
Zurück zum Zitat Bossola M, Giungi S, Luciani G, Tazza L (2011) Interventions to counteract anorexia in dialysis patients. J Ren Nutr 21:16–19CrossRefPubMed Bossola M, Giungi S, Luciani G, Tazza L (2011) Interventions to counteract anorexia in dialysis patients. J Ren Nutr 21:16–19CrossRefPubMed
35.
Zurück zum Zitat Bossola M, Tazza L (2012) Xerostomia in patients on chronic hemodialysis. Nat Rev Nephrol 8:176–182CrossRefPubMed Bossola M, Tazza L (2012) Xerostomia in patients on chronic hemodialysis. Nat Rev Nephrol 8:176–182CrossRefPubMed
36.
Zurück zum Zitat Palmer SC, Natale P, Ruospo M et al (2016) Antidepressants for treating depression in adults with end-stage kidney disease treated with dialysis. Cochrane Database Syst Rev 23:CD004541 Palmer SC, Natale P, Ruospo M et al (2016) Antidepressants for treating depression in adults with end-stage kidney disease treated with dialysis. Cochrane Database Syst Rev 23:CD004541
37.
Zurück zum Zitat Sakkas GK, Giannaki CD, Karatzaferi C, Maridaki M, Koutedakis Y, Hadjigeorgiou GM, Stefanidis I (2015) Current trends in the management of uremic restless legs syndrome: a systematic review on aspects related to quality of life, cardiovascular mortality and survival. Sleep Med Rev 21:39–49CrossRefPubMed Sakkas GK, Giannaki CD, Karatzaferi C, Maridaki M, Koutedakis Y, Hadjigeorgiou GM, Stefanidis I (2015) Current trends in the management of uremic restless legs syndrome: a systematic review on aspects related to quality of life, cardiovascular mortality and survival. Sleep Med Rev 21:39–49CrossRefPubMed
Metadaten
Titel
Treating symptoms to improve the quality of life in patients on chronic hemodialysis
verfasst von
Maurizio Bossola
Gilda Pepe
Anna Picca
Riccardo Calvani
Emanuele Marzetti
Publikationsdatum
19.03.2019
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 5/2019
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-019-02121-5

Weitere Artikel der Ausgabe 5/2019

International Urology and Nephrology 5/2019 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren. 

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Wo hapert es noch bei der Umsetzung der POMGAT-Leitlinie?

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Das Risiko für Vorhofflimmern in der Bevölkerung steigt

02.05.2024 Vorhofflimmern Nachrichten

Das Risiko, im Lauf des Lebens an Vorhofflimmern zu erkranken, ist in den vergangenen 20 Jahren gestiegen: Laut dänischen Zahlen wird es drei von zehn Personen treffen. Das hat Folgen weit über die Schlaganfallgefährdung hinaus.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.