Erschienen in:
11.01.2017 | Sleep Breathing Physiology and Disorders • Short Communication
Hydroxyurea treatment effect on children with sickle cell disease and obstructive sleep apnea
verfasst von:
Anthony J. Grady, Jane S. Hankins, Brent Haberman, Robert Schoumacher, Rose Mary Stocks
Erschienen in:
Sleep and Breathing
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Ausgabe 3/2017
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Abstract
Background
While hydroxyurea is the mainstay of treatment for many of the comorbidities associated with sickle cell disease, its effect on obstructive sleep apnea has not been fully investigated. The purpose of this project is to help characterize the effects of hydroxyurea on obstructive sleep apnea in children with sickle cell disease and determine its therapeutic role in the condition.
Methods
Chart review was conducted on two pediatric patients with sickle cell disease who experienced resolution of obstructive sleep apnea following hydroxyurea administration.
Results
After undergoing approximately 11 months of hydroxyurea therapy, sleep apnea symptoms improved and obstructive sleep apnea resolution was confirmed by repeat polysomnography in both cases. This resolution was largely secondary to a reduction in the obstructive component of the apnea hypopnea index, highlighting a previously unreported association.
Conclusions
As adenotonsillectomy is associated with significant risks in patients with sickle cell disease, it appears reasonable to consider a period of observation for improvement of obstructive sleep apnea following hydroxyurea administration rather than directly proceeding with surgery.