Skip to main content
Erschienen in: Sleep and Breathing 1/2019

22.06.2018 | Sleep Breathing Physiology and Disorders • Original Article

Impact of PAP therapy on hospitalization rates in Medicare beneficiaries with COPD and coexisting OSA

verfasst von: Gurinder Singh, Amitesh Agarwal, Wei Zhang, Yong-Fang Kuo, Rizwana Sultana, Gulshan Sharma

Erschienen in: Sleep and Breathing | Ausgabe 1/2019

Einloggen, um Zugang zu erhalten

Abstract

Objective

Growing evidence supports that patients with chronic obstructive pulmonary disease (COPD) and coexisting obstructive sleep apnea (OSA) have poor prognosis. This association is described as overlap syndrome. Positive airway pressure (PAP) therapy is now the preferred treatment for OSA. We hypothesized that use of PAP therapy in elderly patients with overlap syndrome would be associated with lower healthcare utilization.

Methods

In this retrospective cohort study, we analyzed data from 5% national sample of fee-for-service Medicare beneficiaries with a diagnosis of COPD who were newly started on PAP therapy in 2011. We examined the effect of PAP therapy on emergency room (ER) visits and hospitalizations for all-cause and COPD-related conditions in the 1 year pre- and 1 year post-initiation of PAP therapy.

Results

In year 2011, we identified 319 patients with overlap syndrome who were new users of PAP therapy. In this cohort of patients, hospitalization rates for COPD-related conditions were significantly lower in the 1 year post-initiation of PAP therapy compared to the 1-year pre-initiation period (19.4 vs 25.4%, P value = 0.03). However, ER visits (for any cause or COPD-related conditions) and hospitalization rates for any cause did not differ significantly in the pre- and post-initiation periods. PAP therapy was more beneficial in older adults, those with higher COPD complexity, and those with three or more comorbidities.

Conclusion

Initiation of PAP therapy in elderly patients with overlap syndrome is associated with a reduction in hospitalization for COPD-related conditions, but not for all-cause hospitalizations and ER visits.
Literatur
1.
Zurück zum Zitat Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 2013:kws342 Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 2013:kws342
2.
Zurück zum Zitat Gershon AS, Warner L, Cascagnette P, Victor JC, To T (2011) Lifetime risk of developing chronic obstructive pulmonary disease: a longitudinal population study. Lancet 378(9795):991–996CrossRefPubMed Gershon AS, Warner L, Cascagnette P, Victor JC, To T (2011) Lifetime risk of developing chronic obstructive pulmonary disease: a longitudinal population study. Lancet 378(9795):991–996CrossRefPubMed
3.
Zurück zum Zitat Epstein LJ, Kristo D, Strollo PJ Jr et al (2009) Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 5(3):263–276 Epstein LJ, Kristo D, Strollo PJ Jr et al (2009) Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 5(3):263–276
4.
Zurück zum Zitat Soler X, Gaio E, Powell FL, Ramsdell JW, Loredo JS, Malhotra A, Ries AL (2015) High prevalence of obstructive sleep apnea in patients with moderate to severe chronic obstructive pulmonary disease. Annals Am Thoracic Soc 12(8):1219–1225 Soler X, Gaio E, Powell FL, Ramsdell JW, Loredo JS, Malhotra A, Ries AL (2015) High prevalence of obstructive sleep apnea in patients with moderate to severe chronic obstructive pulmonary disease. Annals Am Thoracic Soc 12(8):1219–1225
5.
Zurück zum Zitat Owens RL, Macrea MM, Teodorescu M (2017) The overlaps of asthma or COPD with OSA: a focused review. Respirology 22(6):1073–1083CrossRefPubMed Owens RL, Macrea MM, Teodorescu M (2017) The overlaps of asthma or COPD with OSA: a focused review. Respirology 22(6):1073–1083CrossRefPubMed
6.
Zurück zum Zitat Stanchina ML, Welicky LM, Donat W, Lee D, Corrao W, Malhotra A (2013) Impact of CPAP use and age on mortality in patients with combined COPD and obstructive sleep apnea: the overlap syndrome. J Clin Sleep Med 9(8):767–772PubMedPubMedCentral Stanchina ML, Welicky LM, Donat W, Lee D, Corrao W, Malhotra A (2013) Impact of CPAP use and age on mortality in patients with combined COPD and obstructive sleep apnea: the overlap syndrome. J Clin Sleep Med 9(8):767–772PubMedPubMedCentral
7.
Zurück zum Zitat Shawon MSR, Hamilton G, Perret J, Senaratna C, Lodge C, Dharmage SC. Current evidence on prevalence and clinical outcomes of co-morbid obstructive sleep apnea and chronic obstructive pulmonary disease: a systematic review. Sleep Med Rev 2016 Shawon MSR, Hamilton G, Perret J, Senaratna C, Lodge C, Dharmage SC. Current evidence on prevalence and clinical outcomes of co-morbid obstructive sleep apnea and chronic obstructive pulmonary disease: a systematic review. Sleep Med Rev 2016
8.
Zurück zum Zitat Flenley DC (1985) Sleep in chronic obstructive lung disease. Clin Chest Med 6(4):651–661PubMed Flenley DC (1985) Sleep in chronic obstructive lung disease. Clin Chest Med 6(4):651–661PubMed
9.
Zurück zum Zitat Chaouat A, Weitzenblum E, Krieger J, Ifoundza T, Oswald M, Kessler R (1995) Association of chronic obstructive pulmonary disease and sleep apnea syndrome. Am J Respir Crit Care Med 151(1):82–86CrossRefPubMed Chaouat A, Weitzenblum E, Krieger J, Ifoundza T, Oswald M, Kessler R (1995) Association of chronic obstructive pulmonary disease and sleep apnea syndrome. Am J Respir Crit Care Med 151(1):82–86CrossRefPubMed
10.
Zurück zum Zitat Konikkara J, Tavella R, Willes L, Kavuru M, Sharma S (2016) Early recognition of obstructive sleep apnea in patients hospitalized with COPD exacerbation is associated with reduced readmission. Hospital Practice 44(1):41–47CrossRefPubMed Konikkara J, Tavella R, Willes L, Kavuru M, Sharma S (2016) Early recognition of obstructive sleep apnea in patients hospitalized with COPD exacerbation is associated with reduced readmission. Hospital Practice 44(1):41–47CrossRefPubMed
11.
Zurück zum Zitat Wang Y, Hu K, Liu K, Li Z, Yang J, Dong Y, Nie M, Chen J, Ruan Y, Kang J (2015) Obstructive sleep apnea exacerbates airway inflammation in patients with chronic obstructive pulmonary disease. Sleep Med 16(9):1123–1130CrossRef Wang Y, Hu K, Liu K, Li Z, Yang J, Dong Y, Nie M, Chen J, Ruan Y, Kang J (2015) Obstructive sleep apnea exacerbates airway inflammation in patients with chronic obstructive pulmonary disease. Sleep Med 16(9):1123–1130CrossRef
12.
Zurück zum Zitat Marin JM, Soriano JB, Carrizo SJ, Boldova A, Celli BR (2010) Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Am J Respir Crit Care Med 182(3):325–331CrossRefPubMed Marin JM, Soriano JB, Carrizo SJ, Boldova A, Celli BR (2010) Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Am J Respir Crit Care Med 182(3):325–331CrossRefPubMed
13.
Zurück zum Zitat Machado ML, Vollmer W, Togeiro SM et al (2010) CPAP and survival in moderate-to-severe obstructive sleep apnoea syndrome and hypoxaemic COPD. Eur Respir J 35(1):132–137CrossRefPubMed Machado ML, Vollmer W, Togeiro SM et al (2010) CPAP and survival in moderate-to-severe obstructive sleep apnoea syndrome and hypoxaemic COPD. Eur Respir J 35(1):132–137CrossRefPubMed
14.
Zurück zum Zitat Du W, Liu J, Zhou J, Ye D, OuYang Y, Deng Q (2018) Obstructive sleep apnea, COPD, the overlap syndrome, and mortality: results from the 2005-2008 National Health and Nutrition Examination Survey. Int J Chron Obstruct Pulmon Dis 13:665–674CrossRefPubMedPubMedCentral Du W, Liu J, Zhou J, Ye D, OuYang Y, Deng Q (2018) Obstructive sleep apnea, COPD, the overlap syndrome, and mortality: results from the 2005-2008 National Health and Nutrition Examination Survey. Int J Chron Obstruct Pulmon Dis 13:665–674CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Jaoude P, Kufel T, El-Solh AA (2014) Survival benefit of CPAP favors hypercapnic patients with the overlap syndrome. Lung 192(2):251–258CrossRefPubMed Jaoude P, Kufel T, El-Solh AA (2014) Survival benefit of CPAP favors hypercapnic patients with the overlap syndrome. Lung 192(2):251–258CrossRefPubMed
16.
Zurück zum Zitat Chandra D, Stamm JA, Taylor B, Ramos RM, Satterwhite L, Krishnan JA, Mannino D, Sciurba FC, Holguín F (2012) Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998–2008. Am J Respir Crit Care Med 185(2):152–159CrossRefPubMedPubMedCentral Chandra D, Stamm JA, Taylor B, Ramos RM, Satterwhite L, Krishnan JA, Mannino D, Sciurba FC, Holguín F (2012) Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998–2008. Am J Respir Crit Care Med 185(2):152–159CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Javaheri S, Caref EB, Chen E, Tong KB, Abraham WT (2011) Sleep apnea testing and outcomes in a large cohort of Medicare beneficiaries with newly diagnosed heart failure. Am J Respir Crit Care Med 183(4):539–546CrossRefPubMed Javaheri S, Caref EB, Chen E, Tong KB, Abraham WT (2011) Sleep apnea testing and outcomes in a large cohort of Medicare beneficiaries with newly diagnosed heart failure. Am J Respir Crit Care Med 183(4):539–546CrossRefPubMed
19.
Zurück zum Zitat Elixhauser A, Steiner C, Harris DR, Coffey RM (1998) Comorbidity measures for use with administrative data. Med Care 36(1):8–27CrossRefPubMed Elixhauser A, Steiner C, Harris DR, Coffey RM (1998) Comorbidity measures for use with administrative data. Med Care 36(1):8–27CrossRefPubMed
20.
Zurück zum Zitat Mapel DW, Dutro MP, Marton JP, Woodruff K, Make B (2011) Identifying and characterizing COPD patients in US managed care. A retrospective, cross-sectional analysis of administrative claims data. BMC Health Serv Res 11(1):43CrossRefPubMedPubMedCentral Mapel DW, Dutro MP, Marton JP, Woodruff K, Make B (2011) Identifying and characterizing COPD patients in US managed care. A retrospective, cross-sectional analysis of administrative claims data. BMC Health Serv Res 11(1):43CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Parish JM, Somers VK. Obstructive sleep apnea and cardiovascular disease. Paper presented at: Mayo Clinic Proceedings2004 Parish JM, Somers VK. Obstructive sleep apnea and cardiovascular disease. Paper presented at: Mayo Clinic Proceedings2004
22.
Zurück zum Zitat McNicholas WT (2009) Chronic obstructive pulmonary disease and obstructive sleep apnea: overlaps in pathophysiology, systemic inflammation, and cardiovascular disease. Am J Respir Crit Care Med 180(8):692–700CrossRefPubMed McNicholas WT (2009) Chronic obstructive pulmonary disease and obstructive sleep apnea: overlaps in pathophysiology, systemic inflammation, and cardiovascular disease. Am J Respir Crit Care Med 180(8):692–700CrossRefPubMed
23.
Zurück zum Zitat Mulloy E, McNicholas WT (1996) Ventilation and gas exchange during sleep and exercise in severe COPD. Chest 109(2):387–394CrossRefPubMed Mulloy E, McNicholas WT (1996) Ventilation and gas exchange during sleep and exercise in severe COPD. Chest 109(2):387–394CrossRefPubMed
24.
Zurück zum Zitat Sanders MH, Newman AB, Haggerty CL, Redline S, Lebowitz M, Samet J, O’Connor GT, Punjabi NM, Shahar E, Sleep Heart Health Study (2003) Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med 167(1):7–14CrossRefPubMed Sanders MH, Newman AB, Haggerty CL, Redline S, Lebowitz M, Samet J, O’Connor GT, Punjabi NM, Shahar E, Sleep Heart Health Study (2003) Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med 167(1):7–14CrossRefPubMed
25.
Zurück zum Zitat Ryan S, Taylor C, McNicholas W (2009) Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Thorax 64(7):631–636PubMed Ryan S, Taylor C, McNicholas W (2009) Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Thorax 64(7):631–636PubMed
26.
Zurück zum Zitat Donaldson GC, Seemungal TA, Patel IS et al (2005) Airway and systemic inflammation and decline in lung function in patients with COPD. CHEST J 128(4):1995–2004CrossRef Donaldson GC, Seemungal TA, Patel IS et al (2005) Airway and systemic inflammation and decline in lung function in patients with COPD. CHEST J 128(4):1995–2004CrossRef
27.
Zurück zum Zitat Fortuna AM, Miralda R, Calaf N, González M, Casan P, Mayos M (2011) Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome. Respir Med 105(4):630–636CrossRefPubMed Fortuna AM, Miralda R, Calaf N, González M, Casan P, Mayos M (2011) Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome. Respir Med 105(4):630–636CrossRefPubMed
28.
Zurück zum Zitat Lacedonia D, Carpagnano G, Aliani M et al (2013) Daytime PaO 2 in OSAS, COPD and the combination of the two (overlap syndrome). Respir Med 107(2):310–316CrossRefPubMed Lacedonia D, Carpagnano G, Aliani M et al (2013) Daytime PaO 2 in OSAS, COPD and the combination of the two (overlap syndrome). Respir Med 107(2):310–316CrossRefPubMed
29.
Zurück zum Zitat Joynt KE, Jha AK (2013) Characteristics of hospitals receiving penalties under the Hospital Readmissions Reduction Program. JAMA 309(4):342–343CrossRefPubMed Joynt KE, Jha AK (2013) Characteristics of hospitals receiving penalties under the Hospital Readmissions Reduction Program. JAMA 309(4):342–343CrossRefPubMed
30.
Zurück zum Zitat Stein BD, Bautista A, Schumock GT, Lee TA, Charbeneau JT, Lauderdale DS, Naureckas ET, Meltzer DO, Krishnan JA (2012) The validity of International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes for identifying patients hospitalized for COPD exacerbations. CHEST Journal 141(1):87–93CrossRef Stein BD, Bautista A, Schumock GT, Lee TA, Charbeneau JT, Lauderdale DS, Naureckas ET, Meltzer DO, Krishnan JA (2012) The validity of International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes for identifying patients hospitalized for COPD exacerbations. CHEST Journal 141(1):87–93CrossRef
Metadaten
Titel
Impact of PAP therapy on hospitalization rates in Medicare beneficiaries with COPD and coexisting OSA
verfasst von
Gurinder Singh
Amitesh Agarwal
Wei Zhang
Yong-Fang Kuo
Rizwana Sultana
Gulshan Sharma
Publikationsdatum
22.06.2018
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing / Ausgabe 1/2019
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-018-1680-0

Weitere Artikel der Ausgabe 1/2019

Sleep and Breathing 1/2019 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.