Skip to main content
Erschienen in: Journal of General Internal Medicine 4/2015

01.04.2015 | Original Research

Practice Context Affects Efforts to Improve Diabetes Care for Primary Care Patients: A Pragmatic Cluster Randomized Trial

verfasst von: L. Miriam Dickinson, PhD, W. Perry Dickinson, MD, Paul A. Nutting, MD, MSPH, Lawrence Fisher, PhD, Marjie Harbrecht, MD, Benjamin F. Crabtree, PhD, Russell E. Glasgow, PhD, David R. West, PhD

Erschienen in: Journal of General Internal Medicine | Ausgabe 4/2015

Einloggen, um Zugang zu erhalten

Abstract

Background

Efforts to improve primary care diabetes management have assessed strategies across heterogeneous groups of patients and practices. However, there is substantial variability in how well practices implement interventions and achieve desired outcomes.

Objective

To examine practice contextual features that moderate intervention effectiveness.

Design

Secondary analysis of data from a cluster randomized trial of three approaches for implementing the Chronic Care Model to improve diabetes care.

Participants

Forty small to mid-sized primary care practices participated, with 522 clinician and staff member surveys. Outcomes were assessed for 822 established patients with a diagnosis of type 2 diabetes who had at least one visit to the practice in the 18 months following enrollment.

Main Measures

The primary outcome was a composite measure of diabetes process of care, ascertained by chart audit, regarding nine quality measures from the American Diabetes Association Physician Recognition Program: HgA1c, foot exam, blood pressure, dilated eye exam, cholesterol, nephropathy screen, flu shot, nutrition counseling, and self-management support. Data from practices included structural and demographic characteristics and Practice Culture Assessment survey subscales (Change Culture, Work Culture, Chaos).

Key Results

Across the three implementation approaches, demographic/structural characteristics (rural vs. urban + .70(p = .006), +2.44(p < .001), −.75(p = .004)); Medicaid: <20 % vs. ≥20 % (−.20(p = .48), +.75 (p = .08), +.60(p = .02)); practice size: <4 clinicians vs. ≥4 clinicians (+.56(p = .02), +1.96( p < .001), +.02(p = .91)); practice Change Culture (high vs. low: −.86(p = .048), +1.71(p = .005), +.34(p = .22)), Work Culture (high vs. low: −.67(p = .18), +2.41(p < .001), +.67(p = .005)) and variability in practice Change Culture (high vs. low: −.24(p = .006), −.20(p = .0771), −.44(p = .0019) and Work Culture (high vs. low: +.56(p = .3160), −1.0(p = .008), −.25 (p = .0216) were associated with trajectories of change in diabetes process of care, either directly or differentially by study arm.

Conclusions

This study supports the need for broader use of methodological approaches to better examine contextual effects on implementation and effectiveness of quality improvement interventions in primary care settings.
Literatur
2.
Zurück zum Zitat Wagner EH, Austin BT, Von Korff M. Improving outcomes in chronic illness. Manage Care Q. 1996;4:12–25. Wagner EH, Austin BT, Von Korff M. Improving outcomes in chronic illness. Manage Care Q. 1996;4:12–25.
3.
Zurück zum Zitat Bodenheimer T, Wagner EH, Grumbach K. Improving primary care for patients with chronic illness. JAMA. 2002;288(14):1775–1779.CrossRefPubMed Bodenheimer T, Wagner EH, Grumbach K. Improving primary care for patients with chronic illness. JAMA. 2002;288(14):1775–1779.CrossRefPubMed
4.
Zurück zum Zitat Dickinson WP, Dickinson LM, Nutting PA, Emsermann C, Tutt B, Crabtree BF, Fisher L, Harbrecht M, Gottsman A, West DR. Practice facilitation to improve diabetes care in primary care: A report from the EPIC randomized clinical trial. Ann Fam Med. 2014;12(1):8–16.CrossRefPubMedCentralPubMed Dickinson WP, Dickinson LM, Nutting PA, Emsermann C, Tutt B, Crabtree BF, Fisher L, Harbrecht M, Gottsman A, West DR. Practice facilitation to improve diabetes care in primary care: A report from the EPIC randomized clinical trial. Ann Fam Med. 2014;12(1):8–16.CrossRefPubMedCentralPubMed
5.
Zurück zum Zitat Nutting PA, Dickinson WP, Dickinson LM, Nelson CC, King DK, Crabtree BF, Glasgow RE. Use of chronic care model elements is associated with higher-quality care for diabetes. Ann Fam Med. 2007;5(1):14–20.CrossRefPubMedCentralPubMed Nutting PA, Dickinson WP, Dickinson LM, Nelson CC, King DK, Crabtree BF, Glasgow RE. Use of chronic care model elements is associated with higher-quality care for diabetes. Ann Fam Med. 2007;5(1):14–20.CrossRefPubMedCentralPubMed
6.
Zurück zum Zitat Parchman ML, Noel PH, Culler SD, Lanham HJ, Leykum LK, Romero RL, Palmer RF. A randomized trial of practice facilitation to improve the delivery of chronic illness care in primary care: initial and sustained effects. Implement Sci. 2013;8:93.CrossRefPubMedCentralPubMed Parchman ML, Noel PH, Culler SD, Lanham HJ, Leykum LK, Romero RL, Palmer RF. A randomized trial of practice facilitation to improve the delivery of chronic illness care in primary care: initial and sustained effects. Implement Sci. 2013;8:93.CrossRefPubMedCentralPubMed
7.
Zurück zum Zitat Stellefson M, Dipnarine K, Stopka C. The chronic care model and diabetes management in US primary care setting. Prev Chron Dis. 2013;10:E26. Stellefson M, Dipnarine K, Stopka C. The chronic care model and diabetes management in US primary care setting. Prev Chron Dis. 2013;10:E26.
8.
Zurück zum Zitat Coleman K, Austin BT, Brach C, Wagner EH. Evidence on the chronic care model in the new millennium. Health Aff. 2009;28(1):75–85.CrossRef Coleman K, Austin BT, Brach C, Wagner EH. Evidence on the chronic care model in the new millennium. Health Aff. 2009;28(1):75–85.CrossRef
9.
Zurück zum Zitat Shaw EK, Howard J, West DR, Crabtree BF, Nease DE, Tutt B, Nutting PA. The role of the champion in primary care change efforts. J Am Board Fam Med. 2012;25(5):676–685.CrossRefPubMedCentralPubMed Shaw EK, Howard J, West DR, Crabtree BF, Nease DE, Tutt B, Nutting PA. The role of the champion in primary care change efforts. J Am Board Fam Med. 2012;25(5):676–685.CrossRefPubMedCentralPubMed
10.
Zurück zum Zitat Crabtree BF, Nutting PA, Miller WL, McDaniel RR, Stange KC, Jaen CR, Stewart EE. Primary care practice transformation is hard work: Insights from a 15-year developmental program of research. Med Care. 2011;49:S28–S35.CrossRefPubMedCentralPubMed Crabtree BF, Nutting PA, Miller WL, McDaniel RR, Stange KC, Jaen CR, Stewart EE. Primary care practice transformation is hard work: Insights from a 15-year developmental program of research. Med Care. 2011;49:S28–S35.CrossRefPubMedCentralPubMed
11.
Zurück zum Zitat Danz MS, Hempel S, Lim YW, Shaman R, Motala A, Stockdale S, Shekelle P, Rubenstein L. Incorporating evidence review into quality improvement: meeting the needs of innovators. BMJ Qual Saf. 2013;22:931–939. Danz MS, Hempel S, Lim YW, Shaman R, Motala A, Stockdale S, Shekelle P, Rubenstein L. Incorporating evidence review into quality improvement: meeting the needs of innovators. BMJ Qual Saf. 2013;22:931–939.
12.
Zurück zum Zitat Dickinson LM, Dickinson WP, Rost K, deGruy F, Emsermann C, Forshaug D, Nutting PA, Meredith L. Clinician burden and depression treatment: Disentangling patient- and clinician-level effects of medical comorbidity. J Gen Intern Med. 2008;23(11):1763–1769.CrossRefPubMedCentralPubMed Dickinson LM, Dickinson WP, Rost K, deGruy F, Emsermann C, Forshaug D, Nutting PA, Meredith L. Clinician burden and depression treatment: Disentangling patient- and clinician-level effects of medical comorbidity. J Gen Intern Med. 2008;23(11):1763–1769.CrossRefPubMedCentralPubMed
13.
Zurück zum Zitat Li R, Simon J, Bodenheimer T, Gillies RR, Casalino L, Schmittdiel J, Shortell SM. Organizational factors affecting the adoption of diabetes care management processes in physician organizations. Diabetes Care. 2004;27(10):2312–2316.CrossRefPubMed Li R, Simon J, Bodenheimer T, Gillies RR, Casalino L, Schmittdiel J, Shortell SM. Organizational factors affecting the adoption of diabetes care management processes in physician organizations. Diabetes Care. 2004;27(10):2312–2316.CrossRefPubMed
14.
Zurück zum Zitat Noel PH, Lanham HJ, Palmer RF, Leykum LK, Parchman ML. The importance of relational coordination and reciprocal learning for chronic illness care within primary care teams. Health Care Manag Rev. 2013;38(1):20–28.CrossRef Noel PH, Lanham HJ, Palmer RF, Leykum LK, Parchman ML. The importance of relational coordination and reciprocal learning for chronic illness care within primary care teams. Health Care Manag Rev. 2013;38(1):20–28.CrossRef
15.
Zurück zum Zitat Kaissi A, Kralewski J, Curoe A, Dowd B, Silversmith J. How does the culture of medical group practices influence the types of programs used to assure quality of care? Health Care Manag Rev. 2004;29(2):129–138.CrossRef Kaissi A, Kralewski J, Curoe A, Dowd B, Silversmith J. How does the culture of medical group practices influence the types of programs used to assure quality of care? Health Care Manag Rev. 2004;29(2):129–138.CrossRef
16.
Zurück zum Zitat Bosch M, Dijkstra R, Wensing M, van der Weijden T, Grol R. Organizational culture, team climate and diabetes care in small office-based practices. BMC Health Serv Res. 2008;8:180.CrossRefPubMedCentralPubMed Bosch M, Dijkstra R, Wensing M, van der Weijden T, Grol R. Organizational culture, team climate and diabetes care in small office-based practices. BMC Health Serv Res. 2008;8:180.CrossRefPubMedCentralPubMed
17.
Zurück zum Zitat Nembhard IM, Singer SJ, Shortell SM, Rittenhouse D, Casalino LP. The cultural complexity of medical groups. Health Care Manag Rev. 2012;37(3):200–213.CrossRef Nembhard IM, Singer SJ, Shortell SM, Rittenhouse D, Casalino LP. The cultural complexity of medical groups. Health Care Manag Rev. 2012;37(3):200–213.CrossRef
18.
Zurück zum Zitat Shortell SM, Gillies R, Siddique J, Casalino LP, Rittenhouse D, Robinson JC, McCurdy RD. Improving chronic illness Care: A longitudinal cohort analysis of large physician organizations. Med Care. 2009;47(9):932–939.CrossRefPubMed Shortell SM, Gillies R, Siddique J, Casalino LP, Rittenhouse D, Robinson JC, McCurdy RD. Improving chronic illness Care: A longitudinal cohort analysis of large physician organizations. Med Care. 2009;47(9):932–939.CrossRefPubMed
19.
Zurück zum Zitat Damschroder LJ, Aron DC, Keith RE, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50.CrossRefPubMedCentralPubMed Damschroder LJ, Aron DC, Keith RE, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50.CrossRefPubMedCentralPubMed
21.
Zurück zum Zitat Kraemer HC, Wilson GT, Fairburn CG, Agras WS. Mediators and moderators of treatment effects in randomized clinical trials. Arch Gen Psychiatry. 2002;59:877–883.CrossRefPubMed Kraemer HC, Wilson GT, Fairburn CG, Agras WS. Mediators and moderators of treatment effects in randomized clinical trials. Arch Gen Psychiatry. 2002;59:877–883.CrossRefPubMed
22.
Zurück zum Zitat Bryk AS, Raudenbush SW. Hierarchical Linear Models: Applications and Data Analysis Methods. Second ed. Newbury Park: Sage Publications; 2000. Bryk AS, Raudenbush SW. Hierarchical Linear Models: Applications and Data Analysis Methods. Second ed. Newbury Park: Sage Publications; 2000.
23.
Zurück zum Zitat Hedeker D, Gibbons R, Longitudinal Data Analysis. Hoboken, Hew Jersey: Wiley & Sons; 2006, pp 69–76 Hedeker D, Gibbons R, Longitudinal Data Analysis. Hoboken, Hew Jersey: Wiley & Sons; 2006, pp 69–76
24.
Zurück zum Zitat Stroebel CK, McDaniel RR, Crabtree BF, Miller WL, Nutting PA, Stange KC. How complexity science can inform a reflective process for improvement in primary care practices. Joint Comm J Qual Patient Saf. 2005;31:438–446. Stroebel CK, McDaniel RR, Crabtree BF, Miller WL, Nutting PA, Stange KC. How complexity science can inform a reflective process for improvement in primary care practices. Joint Comm J Qual Patient Saf. 2005;31:438–446.
25.
Zurück zum Zitat Miller WL, Crabtree BF, McDaniel R, Stange KC. Understanding change in primary care practice using complexity theory. J Fam Pract. 1998;46(5):369–376.PubMed Miller WL, Crabtree BF, McDaniel R, Stange KC. Understanding change in primary care practice using complexity theory. J Fam Pract. 1998;46(5):369–376.PubMed
26.
Zurück zum Zitat Balasubramanian BA, Chase SM, Nutting PA, Cohen DJ, Strickland PAO, Crosson JC, Miller WL, Crabtree BF. Using learning teams for reflective adaptation (ULTRA): insights from a team-based change management strategy in primary care. Ann Fam Med. 2010;8:425–432.CrossRefPubMedCentralPubMed Balasubramanian BA, Chase SM, Nutting PA, Cohen DJ, Strickland PAO, Crosson JC, Miller WL, Crabtree BF. Using learning teams for reflective adaptation (ULTRA): insights from a team-based change management strategy in primary care. Ann Fam Med. 2010;8:425–432.CrossRefPubMedCentralPubMed
29.
Zurück zum Zitat Batalden PB, Stoltz PK. A framework for the continual improvement of health care: building and applying professional and improvement knowledge to test changes in daily work. Jt Comm J Qual Improv. 1993;19(10):424–447. discussion 448–452.PubMed Batalden PB, Stoltz PK. A framework for the continual improvement of health care: building and applying professional and improvement knowledge to test changes in daily work. Jt Comm J Qual Improv. 1993;19(10):424–447. discussion 448–452.PubMed
30.
Zurück zum Zitat Berwick DM, Godfrey AB, Roessner J. Curing health care: new strategies for quality improvement. 1st ed. San Francisco: Jossey-Bass; 1990. Berwick DM, Godfrey AB, Roessner J. Curing health care: new strategies for quality improvement. 1st ed. San Francisco: Jossey-Bass; 1990.
31.
Zurück zum Zitat Shortell SM, O'Brien JL, Carman JM, et al. Assessing the impact of continuous quality improvement/total quality management: concept versus implementation. Health Serv Res. 1995;30(2):377–401.PubMedCentralPubMed Shortell SM, O'Brien JL, Carman JM, et al. Assessing the impact of continuous quality improvement/total quality management: concept versus implementation. Health Serv Res. 1995;30(2):377–401.PubMedCentralPubMed
33.
Zurück zum Zitat Crosson JC, Ohman-Strickland PA, Cohen DJ, Clark EC, Crabtree BF. Typical electronic health in primary care practices and the quality of diabetes care. Ann Fam Med. 2012;10:221–227.CrossRefPubMedCentralPubMed Crosson JC, Ohman-Strickland PA, Cohen DJ, Clark EC, Crabtree BF. Typical electronic health in primary care practices and the quality of diabetes care. Ann Fam Med. 2012;10:221–227.CrossRefPubMedCentralPubMed
34.
Zurück zum Zitat Carrier ER, Schneider E, Hoangmai H, Bach PB. Association between quality of care and the sociodemographic composition of physicians’ patient panels: A repeat cross-sectional analysis. J Gen Intern Med. 2011;26(9):987–94.CrossRefPubMedCentralPubMed Carrier ER, Schneider E, Hoangmai H, Bach PB. Association between quality of care and the sociodemographic composition of physicians’ patient panels: A repeat cross-sectional analysis. J Gen Intern Med. 2011;26(9):987–94.CrossRefPubMedCentralPubMed
35.
Zurück zum Zitat Bailey SR, O’Malley JP, Gold R, Heintzman J, Likumahuwa S, DeVoe JE. Diabetes care quality is highly correlated with patient panel characteristics. J Am Board Fam Med. 2013;26:669–679.CrossRefPubMedCentralPubMed Bailey SR, O’Malley JP, Gold R, Heintzman J, Likumahuwa S, DeVoe JE. Diabetes care quality is highly correlated with patient panel characteristics. J Am Board Fam Med. 2013;26:669–679.CrossRefPubMedCentralPubMed
36.
Zurück zum Zitat Russell GM, Dahrouge S, Hogg W, Geneau R, Muldoon L, Tuna M. Managing chronic disease in Ontario primary care: The impact of organizational factors. Ann Fam Med. 2009;7:309–318.CrossRefPubMedCentralPubMed Russell GM, Dahrouge S, Hogg W, Geneau R, Muldoon L, Tuna M. Managing chronic disease in Ontario primary care: The impact of organizational factors. Ann Fam Med. 2009;7:309–318.CrossRefPubMedCentralPubMed
37.
Zurück zum Zitat Damberg CL, Shortell SM, Raube K, Gillies RR, Rittenhouse D, McCurdy RK, Casaline LP, Adams J. Relationship between quality improvement processes and clinical performance. Am J Manage Care. 2010;16(8):601–606. Damberg CL, Shortell SM, Raube K, Gillies RR, Rittenhouse D, McCurdy RK, Casaline LP, Adams J. Relationship between quality improvement processes and clinical performance. Am J Manage Care. 2010;16(8):601–606.
38.
Zurück zum Zitat Beaulier MD, Haggerty J, Tousignant P, Barnsley J, Hogg W, Geneau R, Hudon E, Duplain R, Denis JL, Bonin L, del Grande C, Dragieva N. Characteristics of primary care practices associated with high quality of care. CMAJ. 2013;185(12):ES90–ES96. Beaulier MD, Haggerty J, Tousignant P, Barnsley J, Hogg W, Geneau R, Hudon E, Duplain R, Denis JL, Bonin L, del Grande C, Dragieva N. Characteristics of primary care practices associated with high quality of care. CMAJ. 2013;185(12):ES90–ES96.
39.
Zurück zum Zitat Vamos EP, Pape UJ, Bottle A, Hamilton FL, Curcin V, Ng A, Molokhia M, Car J, Majeed A, Millett C. Association of practice size and pay-for-performance incentives with the quality of diabetes management in primary care. Can Med Assoc J. 2011;183(12):E809–E815.CrossRef Vamos EP, Pape UJ, Bottle A, Hamilton FL, Curcin V, Ng A, Molokhia M, Car J, Majeed A, Millett C. Association of practice size and pay-for-performance incentives with the quality of diabetes management in primary care. Can Med Assoc J. 2011;183(12):E809–E815.CrossRef
40.
Zurück zum Zitat Miller WL, Crabtree BF, Nutting PA, Stange KC, Jaen CR. Primary Care practice development: A relationship-centered approach. Ann Fam Med. 2010;8:S68–S79.CrossRefPubMedCentralPubMed Miller WL, Crabtree BF, Nutting PA, Stange KC, Jaen CR. Primary Care practice development: A relationship-centered approach. Ann Fam Med. 2010;8:S68–S79.CrossRefPubMedCentralPubMed
41.
Zurück zum Zitat Lanham HJ, McDaniel RR, Miller WL, Stange KC, Tallia AF, Nutting PA. How improving practice relationships among clinicians and nonclinicians can improve quality in primary care. Joint Comm J Qual Patient Saf. 2009;35(9):457–466. Lanham HJ, McDaniel RR, Miller WL, Stange KC, Tallia AF, Nutting PA. How improving practice relationships among clinicians and nonclinicians can improve quality in primary care. Joint Comm J Qual Patient Saf. 2009;35(9):457–466.
42.
Zurück zum Zitat Shortell SM, Marsteller JA, Lin M, Pearson ML, Wu SY, Mendel P, Cretin H, Rosen M. The role of perceived team effectiveness in improving chronic illness care. Med Care. 2004;42(11):1040–1048.CrossRefPubMed Shortell SM, Marsteller JA, Lin M, Pearson ML, Wu SY, Mendel P, Cretin H, Rosen M. The role of perceived team effectiveness in improving chronic illness care. Med Care. 2004;42(11):1040–1048.CrossRefPubMed
43.
Zurück zum Zitat Nutting PA, Crabtree BF, McDaniel RR. Small primary care practices face four hurdles – including a physician-centric mind-set –- in becoming medical homes. Health Aff. 2012;31(11):2417–2422.CrossRef Nutting PA, Crabtree BF, McDaniel RR. Small primary care practices face four hurdles – including a physician-centric mind-set –- in becoming medical homes. Health Aff. 2012;31(11):2417–2422.CrossRef
44.
Zurück zum Zitat Balasubramanian BA, Ohman Strickland PA, Crabtree BF. Using learning teams for reflective adaptation: results from a quality improvement intervention to improve adherence to guidelines for diabetes and hypertension in primary care practices. In: North American Primary Care Research Group; October 23–27, 2007. Vancouver, BC: Family Medicine; 2008;40. Balasubramanian BA, Ohman Strickland PA, Crabtree BF. Using learning teams for reflective adaptation: results from a quality improvement intervention to improve adherence to guidelines for diabetes and hypertension in primary care practices. In: North American Primary Care Research Group; October 23–27, 2007. Vancouver, BC: Family Medicine; 2008;40.
Metadaten
Titel
Practice Context Affects Efforts to Improve Diabetes Care for Primary Care Patients: A Pragmatic Cluster Randomized Trial
verfasst von
L. Miriam Dickinson, PhD
W. Perry Dickinson, MD
Paul A. Nutting, MD, MSPH
Lawrence Fisher, PhD
Marjie Harbrecht, MD
Benjamin F. Crabtree, PhD
Russell E. Glasgow, PhD
David R. West, PhD
Publikationsdatum
01.04.2015
Verlag
Springer US
Erschienen in
Journal of General Internal Medicine / Ausgabe 4/2015
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-014-3131-3

Weitere Artikel der Ausgabe 4/2015

Journal of General Internal Medicine 4/2015 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren. 

Wo hapert es noch bei der Umsetzung der POMGAT-Leitlinie?

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Das Risiko für Vorhofflimmern in der Bevölkerung steigt

02.05.2024 Vorhofflimmern Nachrichten

Das Risiko, im Lauf des Lebens an Vorhofflimmern zu erkranken, ist in den vergangenen 20 Jahren gestiegen: Laut dänischen Zahlen wird es drei von zehn Personen treffen. Das hat Folgen weit über die Schlaganfallgefährdung hinaus.

VHF-Ablation nützt wohl nur bei reduzierter Auswurfleistung

02.05.2024 Ablationstherapie Nachrichten

Ob die Katheterablation von Vorhofflimmern bei Patienten mit Herzinsuffizienz die Komplikationsraten senkt, scheint davon abzuhängen, ob die Auswurfleistung erhalten ist oder nicht. Das legen die Ergebnisse einer Metaanalyse nahe.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.