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Erschienen in: Archives of Osteoporosis 1/2020

01.12.2020 | Original Article

Risk factors for subsequent hip fractures and fatality after an initial hip fracture in Korea: using nationwide claims data

verfasst von: Jun-Il Yoo, Ha-Young Kim, Sunmee Jang, Young-Kyun Lee, Yong-Chan Ha

Erschienen in: Archives of Osteoporosis | Ausgabe 1/2020

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Abstract

Summary

In this study, the risk of fatality after hip fracture but not the risk of subsequent hip fractures was higher among men.

Introduction

The purpose of this study was to analyze the risk factors for subsequent hip fractures and fatality after an initial hip fracture among Koreans older than 50 years of age using information in the national claims database.

Methods

Our study was conducted using data from the Korean National Health Insurance Service database from 2007 to 2016. A total of 16,915 Korean patients aged ≥ 50 years with a first hip fracture in 2012 were followed for 4 years. Data on fracture, comorbidity, and prescription variables were retrieved from the national registry. The Cox proportional hazards model was used to identify the risk factors affecting subsequent hip fractures and fatality after the initial hip fracture.

Results

A total of 952 patients had subsequent hip fractures, and 6793 patients died. The cumulative incidence rates were 1.3% after 1 year and 5.6% after 4 years. Old age, renal disease, dementia, and Parkinson’s disease were associated with a higher risk of subsequent hip fractures. The fatality rate after the initial hip fracture was 1.6 times higher among men than among women. Certain risk factors for fatality, such as pneumonia after fracture, cerebrovascular disease, mild liver disease, renal disease, and malignancy, were more prevalent among men.

Conclusion

During the study period, the risk of fatality after hip fracture but not the risk of subsequent hip fractures was higher among men. The gender difference in fatality might be explained by the larger burden of comorbid diseases among men.
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Literatur
1.
Zurück zum Zitat Lems WF, Raterman HG (2017) Critical issues and current challenges in osteoporosis and fracture prevention. An overview of unmet needs. Ther Adv Musculoskelet Dis 9(12):299–316CrossRef Lems WF, Raterman HG (2017) Critical issues and current challenges in osteoporosis and fracture prevention. An overview of unmet needs. Ther Adv Musculoskelet Dis 9(12):299–316CrossRef
2.
Zurück zum Zitat Kontis V, Bennett JE, Mathers CD, Li G, Foreman K, Ezzati M (2017) Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble. Lancet 389(10076):1323–1335CrossRef Kontis V, Bennett JE, Mathers CD, Li G, Foreman K, Ezzati M (2017) Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble. Lancet 389(10076):1323–1335CrossRef
3.
Zurück zum Zitat Doherty DA, Sanders KM, Kotowicz MA, Prince RL (2001) Lifetime and five-year age-specific risks of first and subsequent osteoporotic fractures in postmenopausal women. Osteoporos Int 12(1):16–23CrossRef Doherty DA, Sanders KM, Kotowicz MA, Prince RL (2001) Lifetime and five-year age-specific risks of first and subsequent osteoporotic fractures in postmenopausal women. Osteoporos Int 12(1):16–23CrossRef
4.
Zurück zum Zitat Dennison E, Mohamed MA, Cooper C (2006) Epidemiology of osteoporosis. Rheum Dis Clin N Am 32(4):617–629CrossRef Dennison E, Mohamed MA, Cooper C (2006) Epidemiology of osteoporosis. Rheum Dis Clin N Am 32(4):617–629CrossRef
5.
Zurück zum Zitat Teng GG, Curtis JR, Saag KG (2008) Mortality and osteoporotic fractures: is the link causal, and is it modifiable? Clin Exp Rheumatol 26(5 Suppl 51):S125–S137PubMedPubMedCentral Teng GG, Curtis JR, Saag KG (2008) Mortality and osteoporotic fractures: is the link causal, and is it modifiable? Clin Exp Rheumatol 26(5 Suppl 51):S125–S137PubMedPubMedCentral
6.
Zurück zum Zitat Nazrun AS, Tzar MN, Mokhtar SA, Mohamed IN (2014) A systematic review of the outcomes of osteoporotic fracture patients after hospital discharge: morbidity, subsequent fractures, and mortality. Ther Clin Risk Manag 10:937–948PubMedPubMedCentral Nazrun AS, Tzar MN, Mokhtar SA, Mohamed IN (2014) A systematic review of the outcomes of osteoporotic fracture patients after hospital discharge: morbidity, subsequent fractures, and mortality. Ther Clin Risk Manag 10:937–948PubMedPubMedCentral
7.
Zurück zum Zitat van den Berg P, Schweitzer DH, van Haard PMM, van den Bergh JP, Geusens PP (2015) Meeting international standards of secondary fracture prevention: a survey on Fracture Liaison Services in the Netherlands. Osteoporos Int 26(9):2257–2263CrossRef van den Berg P, Schweitzer DH, van Haard PMM, van den Bergh JP, Geusens PP (2015) Meeting international standards of secondary fracture prevention: a survey on Fracture Liaison Services in the Netherlands. Osteoporos Int 26(9):2257–2263CrossRef
8.
Zurück zum Zitat Akesson K et al (2013) Capture the fracture: a best practice framework and global campaign to break the fragility fracture cycle. Osteoporos Int 24(8):2135–2152CrossRef Akesson K et al (2013) Capture the fracture: a best practice framework and global campaign to break the fragility fracture cycle. Osteoporos Int 24(8):2135–2152CrossRef
9.
Zurück zum Zitat Kwon S (2003) Payment system reform for health care providers in Korea. Health Policy Plan 18(1):84–92CrossRef Kwon S (2003) Payment system reform for health care providers in Korea. Health Policy Plan 18(1):84–92CrossRef
10.
Zurück zum Zitat Kim L, Kim JA, Kim S (2014) A guide for the utilization of health insurance review and assessment service national patient samples. Epidemiol Health 36:e2014008CrossRef Kim L, Kim JA, Kim S (2014) A guide for the utilization of health insurance review and assessment service national patient samples. Epidemiol Health 36:e2014008CrossRef
11.
Zurück zum Zitat Kang HY, Yang KH, Kim YN, Moon SH, Choi WJ, Kang DR, Park SE (2010) Incidence and mortality of hip fracture among the elderly population in South Korea: a population-based study using the national health insurance claims data. BMC Public Health 10:230CrossRef Kang HY, Yang KH, Kim YN, Moon SH, Choi WJ, Kang DR, Park SE (2010) Incidence and mortality of hip fracture among the elderly population in South Korea: a population-based study using the national health insurance claims data. BMC Public Health 10:230CrossRef
12.
Zurück zum Zitat Dafni U (2011) Landmark analysis at the 25-year landmark point. Circ Cardiovasc Qual Outcomes 5(3):363–371CrossRef Dafni U (2011) Landmark analysis at the 25-year landmark point. Circ Cardiovasc Qual Outcomes 5(3):363–371CrossRef
13.
Zurück zum Zitat Ryg J, Rejnmark L, Overgaard S, Brixen K, Vestergaard P (2009) Hip fracture patients at risk of second hip fracture: a nationwide population-based cohort study of 169,145 cases during 1977-2001. J Bone Miner Res 24(7):1299–1307CrossRef Ryg J, Rejnmark L, Overgaard S, Brixen K, Vestergaard P (2009) Hip fracture patients at risk of second hip fracture: a nationwide population-based cohort study of 169,145 cases during 1977-2001. J Bone Miner Res 24(7):1299–1307CrossRef
14.
Zurück zum Zitat Brozek W, Reichardt B, Zwerina J, Dimai HP, Klaushofer K, Zwettler E (2016) Antiresorptive therapy and risk of mortality and refracture in osteoporosis-related hip fracture: a nationwide study. Osteoporos Int 27(1):387–396CrossRef Brozek W, Reichardt B, Zwerina J, Dimai HP, Klaushofer K, Zwettler E (2016) Antiresorptive therapy and risk of mortality and refracture in osteoporosis-related hip fracture: a nationwide study. Osteoporos Int 27(1):387–396CrossRef
15.
Zurück zum Zitat Lee SH, Chen IJ, Li YH, Fan Chiang CY, Chang CH, Hsieh PH (2016) Incidence of second hip fractures and associated mortality in Taiwan: a nationwide population-based study of 95,484 patients during 2006-2010. Acta Orthop Traumatol Turc 50(4):437–442CrossRef Lee SH, Chen IJ, Li YH, Fan Chiang CY, Chang CH, Hsieh PH (2016) Incidence of second hip fractures and associated mortality in Taiwan: a nationwide population-based study of 95,484 patients during 2006-2010. Acta Orthop Traumatol Turc 50(4):437–442CrossRef
16.
Zurück zum Zitat Kanis JA et al (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23(9):2239–2256CrossRef Kanis JA et al (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporos Int 23(9):2239–2256CrossRef
17.
Zurück zum Zitat Lee YK, Ha YC, Choi HJ, Jang S, Park C, Lim YT, Shin CS (2013) Bisphosphonate use and subsequent hip fracture in South Korea. Osteoporos Int 24(11):2887–2892CrossRef Lee YK, Ha YC, Choi HJ, Jang S, Park C, Lim YT, Shin CS (2013) Bisphosphonate use and subsequent hip fracture in South Korea. Osteoporos Int 24(11):2887–2892CrossRef
18.
Zurück zum Zitat Egan M, Jaglal S, Byrne K, Wells J, Stolee P (2008) Factors associated with a second hip fracture: a systematic review. Clin Rehabil 22(3):272–282CrossRef Egan M, Jaglal S, Byrne K, Wells J, Stolee P (2008) Factors associated with a second hip fracture: a systematic review. Clin Rehabil 22(3):272–282CrossRef
19.
Zurück zum Zitat Sheikh HQ, Hossain FS, Khan S, Usman M, Kapoor H, Aqil A (2019) Short-term risk factors for a second hip fracture in a UK population. Eur J Orthop Surg Traumatol 29(5):1055–1060CrossRef Sheikh HQ, Hossain FS, Khan S, Usman M, Kapoor H, Aqil A (2019) Short-term risk factors for a second hip fracture in a UK population. Eur J Orthop Surg Traumatol 29(5):1055–1060CrossRef
20.
Zurück zum Zitat Critchley RJ, Khan SK, Yarnall AJ, Parker MJ, Deehan DJ (2015) Occurrence, management and outcomes of hip fractures in patients with Parkinson’s disease. Br Med Bull 115(1):135–142CrossRef Critchley RJ, Khan SK, Yarnall AJ, Parker MJ, Deehan DJ (2015) Occurrence, management and outcomes of hip fractures in patients with Parkinson’s disease. Br Med Bull 115(1):135–142CrossRef
21.
Zurück zum Zitat Katsoulis M, Benetou V, Karapetyan T, Feskanich D, Grodstein F, Pettersson-Kymmer U, Eriksson S, Wilsgaard T, Jørgensen L, Ahmed LA, Schöttker B, Brenner H, Bellavia A, Wolk A, Kubinova R, Stegeman B, Bobak M, Boffetta P, Trichopoulou A (2017) Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project. J Intern Med 281(3):300–310CrossRef Katsoulis M, Benetou V, Karapetyan T, Feskanich D, Grodstein F, Pettersson-Kymmer U, Eriksson S, Wilsgaard T, Jørgensen L, Ahmed LA, Schöttker B, Brenner H, Bellavia A, Wolk A, Kubinova R, Stegeman B, Bobak M, Boffetta P, Trichopoulou A (2017) Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project. J Intern Med 281(3):300–310CrossRef
22.
Zurück zum Zitat Wehren LE, Hawkes WG, Orwig DL, Hebel JR, Zimmerman SI, Magaziner J (2003) Gender differences in mortality after hip fracture: the role of infection. J Bone Miner Res 18(12):2231–2237CrossRef Wehren LE, Hawkes WG, Orwig DL, Hebel JR, Zimmerman SI, Magaziner J (2003) Gender differences in mortality after hip fracture: the role of infection. J Bone Miner Res 18(12):2231–2237CrossRef
23.
Zurück zum Zitat Berry SD, Samelson EJ, Hannan MT, McLean RR, Lu M, Cupples LA, Shaffer ML, Beiser AL, Kelly-Hayes M, Kiel DP (2007) Second hip fracture in older men and women: the Framingham Study. Arch Intern Med 167(18):1971–1976CrossRef Berry SD, Samelson EJ, Hannan MT, McLean RR, Lu M, Cupples LA, Shaffer ML, Beiser AL, Kelly-Hayes M, Kiel DP (2007) Second hip fracture in older men and women: the Framingham Study. Arch Intern Med 167(18):1971–1976CrossRef
Metadaten
Titel
Risk factors for subsequent hip fractures and fatality after an initial hip fracture in Korea: using nationwide claims data
verfasst von
Jun-Il Yoo
Ha-Young Kim
Sunmee Jang
Young-Kyun Lee
Yong-Chan Ha
Publikationsdatum
01.12.2020
Verlag
Springer London
Erschienen in
Archives of Osteoporosis / Ausgabe 1/2020
Print ISSN: 1862-3522
Elektronische ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-020-00820-6

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