Erschienen in:
01.12.2017 | Upper Gastrointestinal Cancers (L Rajdev, Section Editor)
The Role of Systemic Therapy in Resectable Gastric and Gastro-oesophageal Junction Cancer
verfasst von:
Elizabeth Cartwright, MBBS, David Cunningham, MD FRCP
Erschienen in:
Current Treatment Options in Oncology
|
Ausgabe 12/2017
Einloggen, um Zugang zu erhalten
Opinion statement
Approximately 20% of patients with cancer of the stomach or gastro-oesophageal junction (GOJ) present with resectable disease. Long-term outcome after surgery alone in these patients is poor, and a combined treatment approach is the standard of care. The two approaches to managing patients with cancer of the GOJ are perioperative chemotherapy or preoperative chemoradiotherapy. Based upon the most recent evidence, patients treated with a perioperative approach and deemed suitable for a triplet regimen should be considered for pre- and post-operative FLOT (5-fluorouracil [5-FU], leucovorin, oxaliplatin and docetaxel) and those suitable for a doublet regimen should be considered for a fluoropyrimidine/platinum combination such as capecitabine and oxaliplatin. Alternatively, such patients may be considered for preoperative chemoradiotherapy according to the CROSS regimen. True gastric cancers may be treated with a perioperative approach or, as is commonly used in Asia, postoperative adjuvant chemotherapy.