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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 12/2018

01.12.2018 | Immunologic/Diagnostic Tests in Allergy (P Matricardi, Section Editor)

IgE Test in Secretions of Patients with Respiratory Allergy

verfasst von: Carmen Rondón, Ibon Eguíluz-Gracia, Mohamed H. Shamji, Janice A. Layhadi, María Salas, María José Torres, Paloma Campo

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 12/2018

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Abstract

Purpose of Review

IgE is a key player in multiple inflammatory airway diseases. Ample literature demonstrates its presence in mucosa of patients with allergic rhinitis (AR), local allergic rhinitis (LAR), asthma, or chronic rhinosinusitis with nasal polyposis (CRSwNP).

Recent Findings

Current evidence shows that high-affinity IgE in blood stream of allergic individuals derives mainly from the mucosae. Also, mucosal synthesis of IgE can occur in the absence of systemic atopy, and may be relevant in atopic and non-atopic phenotypes of rhinitis as demonstrated in LAR. Specific IgE (sIgE) detection varies depending on technique used for sample collection and its measurement. sIgE detection is highly specific for diagnosis of LAR. Moreover, measurement of sIgE in secretions could be useful in monitoring response to allergen-specific immunotherapy in both AR and LAR phenotypes.

Summary

This review will focus on recent developments in the role of IgE in respiratory diseases, and the clinical implications of its measurement in secretions.
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Metadaten
Titel
IgE Test in Secretions of Patients with Respiratory Allergy
verfasst von
Carmen Rondón
Ibon Eguíluz-Gracia
Mohamed H. Shamji
Janice A. Layhadi
María Salas
María José Torres
Paloma Campo
Publikationsdatum
01.12.2018
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 12/2018
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-018-0821-7

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