Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Current Diabetes Reports
Erschienen in: Current Diabetes Reports 10/2014

01.10.2014 | Microvascular Complications—Neuropathy (D Ziegler, Section Editor)

Is There an Association Between Diabetic Neuropathy and Low Vitamin D Levels?

verfasst von: Zsuzsanna Putz, Tímea Martos, Nóra Németh, Anna Erzsébet Körei, Orsolya Erzsébet Vági, Miklós Soma Kempler, Péter Kempler

Erschienen in: Current Diabetes Reports | Ausgabe 10/2014

Einloggen, um Zugang zu erhalten

Abstract

In the past few years, the effects of vitamin D that go beyond its relationship with bone metabolism have come into the focus of scientific attention. Research concerning diabetes and its complications has become a public health priority. An increasing number of reports link vitamin D deficiency to diabetes; however, so far, there has only been limited and contradictory data available on the correlation between diabetic peripheral neuropathy and vitamin D. Studies of people with type 2 diabetes confirmed the relationship between vitamin D deficiency and neuropathy incidence as well as the severity of the symptoms caused by neuropathy. The latest studies are also suggesting a relationship between the incidence of plantar ulcers and vitamin D deficiency.
Literatur
1.
Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, et al. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014;348:g1903.PubMedCrossRefPubMedCentral
2.
International Diabetes Federation. IDF Diabetes Atlas 6th edn. Brussels: International Diabetes Federation; 2013.
3.
Wolden-Kirk H, Rondas D, Bugliani M, Korf H, Van Lommel L, Brusgaard K, et al. Discovery of molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and male mouse islets of Langerhans. Endocrinology. 2014;155(3):736–47.PubMedCrossRef
4.
Raab J, Giannopoulou EZ, Schneider S, Warncke K, Krasmann M, Winkler C, et al. Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression. Diabetologia. 2014;57(5):902–8.PubMedCrossRef
5.
Scragg R, Sowers M, Bell C. Third National Health and Nutrition Examination Survey, serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004;27(12):2813–8.PubMedCrossRef
6.
Putz Z, Hermányi Z, Tóth N, Istenes I, Keresztes K, Jermendy G, et al. A distalis típusú, sensoros neuropathia diagnosztikája a diabetológiai gyakorlatban. Diabetologia Hungarica. 2008;16:157–64.
7.
Zs P, Kempler P, Jermendy G. Diabetes specifikus szövődmények prediabetesben. Orv Hetil. 2009;150(47):2139–45.CrossRef
8.
Ziegler D. Diabetic cardiovascular autonomic neuropathy: prognosis, diagnosis and treatment. Diabetes Metab Rev. 1994;10(4):339–83.PubMedCrossRef
9.
Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 2005;29:21–30.PubMedCrossRef
10.
Freedman DM, Dosemeci M, Alavanja MC. Mortality from multiple sclerosis and exposure to residential and occupational solar radiation: a case–control study based on death certificates. Occup Environ Me. 2000;57:418–21.CrossRef
11.
Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296:2832–8.PubMedCrossRef
12.
van der Mei IA, Ponsonby AL, Dwyer T, Blizzard L, Taylor BV, Kilpatrick T, et al. Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia. J Neurol. 2007;254:581–90.PubMedCrossRef
13.
Simpson Jr S, Taylor B, Blizzard L, Ponsonby AL, Pittas F, Tremlett H, et al. I., Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann Neurol. 2010;68:193–203.PubMed
14.
Soilu-Hänninen M, Laaksonen M, Laitinen I, Erälinna JP, Lilius EM, Mononen I. A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008;79:152–7.PubMedCrossRef
15.
Mowry EM, Krupp LB, Milazzo M, Chabas D, Strober JB, Belman AL, et al. Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol. 2010;67:618–24.PubMed
16.
Correale J, Ysrraelit MC, Gaitán MI. Immunmodulatory effects of vitamin D in multiple sclerosis. Brain. 2009;132:1146–60.PubMedCrossRef
17.
Burton JM, Kimball S, Vieth R, Bar-Or A, Dosch HM, Cheung R, et al. A phase I/II doseescalation trial of vitamin D3 and calcium in multiple sclerosis. Neurology. 2010;74:1852–9.PubMedCrossRefPubMedCentral
18.
Smolders J, Hupperts R, Barkhof F, Grimaldi LM, Holmoy T, Killestein J, et al. Efficacy of vitamin D(3) as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: a Phase II, multicenter, double-blind, randomized, placebo-controlled trial. J Neurol Sci. 2011;311:44–9.PubMedCrossRef
19.
Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, et al. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010;170(13):1135–41.PubMedCrossRefPubMedCentral
20.
Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Sääksjärvi K, Heliövaara M. Serum vitamin D and the risk of Parkinson disease. Arch Neurol. 2010;67(7):808–11.PubMedCrossRefPubMedCentral
21.
Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, et al. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013;81(17):1531–7.PubMedCrossRef
22.
Lee P, Chen R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch Intern Med. 2008;168:771–2.PubMedCrossRef
23.
Shebab D, Al-Jarallah K, Mojiminiyi OA, Al Mohamedy H, Abdella NA. Does vitamin D deficiency play a role in peripheral neuropathy in type 2 diabetes? Diabet Med. 2012;29:43–9.CrossRef
24.
Valensi P, Devehat C, Richard JL, Farez C, Khodabandehlou T, Rosenbloom RA, et al. A multicenter double blind, safety study of QR-333 for treatment of symptomatic diabetic peripheral neuropathy: a preliminary report. J Diabetes Complicat. 2005;19:247–53.PubMedCrossRef
25.••
Soderstrom LH, Johnson SP, Diaz VA, Mainous 3rd AG. Association between vitamin D and diabetic neuropathy in a nationally reperesentative sample: results from 2001–2004 NHANES. Diabet Med. 2012;29:50–5. This study analyses a representative sample, proving that Vitamin D is insufficiency associated with self-reported peripheral neuropathy symptoms. PubMedCrossRefPubMedCentral
26.
Skalli S, Muller M, Pradines S, Halimi S, Wion-Barbot N. Vitamin D deficiency and peripheral diabetic neuropathy. Eur J Intern Med. 2012;23:67–8.CrossRef
27.
Ahmadieh H, Azar ST, Lakkis N, Arabi A. Hypovitaminosis D in patients with type 2 diabetes mellitus: a relation to disease control and complications. ISRN Endocrinol. 2013;22(2013):641098.
28.
Riaz S, Malcangio M, Miller M, Tomlinson DR. A vitamin D3 derivative (CB1093) induces nerve growth factor and prevents neurothrophic deficits in streptozotocin-diabetic rats. Diabetologia. 1999;42:1308–13.PubMedCrossRef
29.
Riaz S, Tomlinson DR. Pharmacological modulation of nerve growth factor synthesis: a mechanistic comparison of vitamin D receptor and beta(2)-adrenoreceptor agonists. Brain Res Mol. 2000;85:179–88.CrossRef
30.
Filipović N, Ferhatović L, Marelja I, Puljak L, Grković I. Increased vitamin D receptor expression in dorsal root ganglia neurons of diabetic rats. Neurosci Lett. 2013;9(549):140–5.CrossRef
31.
Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculosceletal pain. Mayo Clin Proc. 2003;78:1463–70.PubMedCrossRef
32.
Bell DSH, Reversal of the symptoms of diabetic neuropathy through correction of vitamin D deficiency in a type 1 diabetic patient. Case Report in Endocrinology, 2012: p. 1–3.
33.
Bell DSH. Protean manifestations of vitamin D deficiency, part 2: deficiency and its association with autotoimmune disease, cancer, infection, asthma, dermopathies, insulin resistance, and type 2 diabetes. South Med J. 2011;335–339:335–9.CrossRef
34.
Van Etten E, Branisteanu DD, Verstuyf A, Waer M, Bouillon R, Mathieu C. Analogs of 1,25-dihydroxyvitamin D3 as dose-reducing agents for classical immunosuppressants. Transplantation. 2000;69:1932–42.PubMedCrossRef
35.•
Zubair M, Malik A, Meerza D, Ahmad J. 25-hydroxyvitamin D [25(OH)D] levels and diabetic foot ulcer: is there any relationship? Diabetes Metab Synd. 2013;7:148–53. Diabetic foot ulcer is a burden for the developed industrial countries, nearly half of all lower-leg amputations of a non-traumatic origin are performed on patients with diabetes. Vitamin D have a possible effect in decreasing this huge number. CrossRef
36.
Hutchinson MS, Figenschau Y, Njølstad I, Schirmer H, Jorde R. Serum 25-hydroxyvitamin D levels are inversely associated with glycated haemoglobin (HbA(1c)). The Tromsø Study. Scand J Clin Lab Invest. 2011;71(5):399–406.PubMedCrossRef
37.
Zoppini G, Galletti A, Targher G, Brangani C, Pichiri I, Negri C, et al. Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients. PLoS One. 2013;8(12):e82733.PubMedCrossRefPubMedCentral
Metadaten
Titel
Is There an Association Between Diabetic Neuropathy and Low Vitamin D Levels?
verfasst von
Zsuzsanna Putz
Tímea Martos
Nóra Németh
Anna Erzsébet Körei
Orsolya Erzsébet Vági
Miklós Soma Kempler
Péter Kempler
Publikationsdatum
01.10.2014
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 10/2014
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-014-0537-6

Weitere Artikel der Ausgabe 10/2014

Current Diabetes Reports 10/2014 Zur Ausgabe

Invited Commentary

Non-Proteinuric Diabetic Nephropathy

Diabetes Epidemiology (NM Maruthur)

Famines in the Last 100 Years: Implications for Diabetes

Psychosocial Aspects (KK Hood, Section Editor)

Neurocognitive Outcomes in Pediatric Diabetes: a Developmental Perspective

Psychosocial Aspects (KK Hood, Section Editor)

Motivational Interviewing to Promote Adherence Behaviors in Pediatric Type 1 Diabetes

Microvascular Complications—Neuropathy (D Ziegler, Section Editor)

The Role of Sodium Channels in Painful Diabetic and Idiopathic Neuropathy

Psychosocial Aspects (KK Hood, Section Editor)

Getting a Technology-Based Diabetes Intervention Ready for Prime Time: a Review of Usability Testing Studies

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Erhöhte Mortalität bei postpartalem Brustkrebs

07.05.2024 Mammakarzinom Nachrichten

Auch für Trägerinnen von BRCA-Varianten gilt: Erkranken sie fünf bis zehn Jahre nach der letzten Schwangerschaft an Brustkrebs, ist das Sterberisiko besonders hoch.

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

07.05.2024 Harnblasenkarzinom Nachrichten

Eine hypertherme intravesikale Chemotherapie mit Mitomycin kann für Patienten mit hochriskantem nicht muskelinvasivem Blasenkrebs eine Alternative zur radikalen Zystektomie darstellen. Kölner Urologen berichten über ihre Erfahrungen.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Medizinstudium Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Vorhofflimmern bei Jüngeren gefährlicher als gedacht

06.05.2024 Vorhofflimmern Nachrichten

Immer mehr jüngere Menschen leiden unter Vorhofflimmern. Betroffene unter 65 Jahren haben viele Risikofaktoren und ein signifikant erhöhtes Sterberisiko verglichen mit Gleichaltrigen ohne die Erkrankung.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise