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Current HIV/AIDS Reports

Erschienen in:

01.05.2010

HIV and Aging: Time for a New Paradigm

verfasst von: Amy C. Justice

Erschienen in: Current HIV/AIDS Reports | Ausgabe 2/2010

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Abstract

The population of patients with HIV infection achieving viral suppression on combination antiretroviral therapy is growing, aging, and experiencing a widening spectrum of non-AIDS diseases. Concurrently, AIDS-defining conditions are becoming less common and are variably associated with outcome. Nonetheless, the spectrum of disease experienced by those aging with HIV remains strongly influenced by HIV, its treatment, and the behaviors, conditions, and demographics associated with HIV infection. Our focus must shift from a narrow interest in CD4 counts, HIV-RNA, and AIDS-defining illnesses to determining the optimal management of HIV infection as a complex chronic disease in which the causes of morbidity and mortality are multiple and overlapping. We need a new paradigm of care with which to maximize functional status, minimize frailty, and prolong life expectancy. A composite index that summarizes a patient’s risk of morbidity and mortality could facilitate this work and help chart its progress.

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20.

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22.

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23.

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24.

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27.

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28.

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29.

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30.

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31.

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39.

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40.

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42.

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43.

•• Oursler KK, Sorkin JD, Smith BA, Katzel LI: Reduced aerobic capacity and physical functioning in older HIV-infected men. AIDS Res Hum Retroviruses 2006, 22:1113–1121. These two references [42]••, [43]••] provide initial evidence for the importance of functional capacity among those aging with HIV.

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50.

•• Justice AC, McGinnis KA, Skanderson M, et al.: Towards a combined prognostic index for survival in HIV infection: the role of ‘non-HIV’ biomarkers. HIV Med 2009, 11:143–151. This article reports the initial development and validation of the VACS risk index and compares its prognostic accuracy to an index restricted to CD4 count, HIV-1 RNA, and AIDS-defining conditions. CrossRefPubMed

Titel: HIV and Aging: Time for a New Paradigm
verfasst von: Amy C. Justice
Publikationsdatum: 01.05.2010
Verlag: Current Science Inc.
Erschienen in: Current HIV/AIDS Reports / Ausgabe 2/2010
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-010-0041-9

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