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Current Oncology Reports

Erschienen in:

01.04.2012 | Evolving Therapies (RM Bukowski, Section Editor)

PI3K and mTOR Signaling Pathways in Cancer: New Data on Targeted Therapies

verfasst von: Lise Willems, Jerome Tamburini, Nicolas Chapuis, Catherine Lacombe, Patrick Mayeux, Didier Bouscary

Erschienen in: Current Oncology Reports | Ausgabe 2/2012

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Abstract

The mammalian target of rapamycin (mTOR) and the phosphoinositide 3-kinase (PI3K) signaling pathways are commonly deregulated in cancers and promote cellular growth, proliferation, and survival. mTOR is part of two complexes, mTORC1 and mTORC2, with different biochemical structures and substrates specificity. PI3K/AKT activation may result from genetic hits affecting different components of the pathway, whereas the mechanisms leading to constitutive mTORC1 activation remain globally unknown. The connections between the PI3K and mTOR kinases are multiple and complex, including common substrates, negative feedback loops, or direct activation mechanisms. First-generation allosteric mTOR inhibitors (eg, rapamycin) are mainly active on mTORC1 and mostly display cytostatic anti-tumor activity. Recently, second-generation catalytic mTOR inhibitors targeting both mTOR complexes 1 and 2 have been developed. Some of them also inhibit class IA PI3K. Here, we highlight recent data generated with these new inhibitors against cancer cells and their potential as anti-cancer drugs.

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Titel: PI3K and mTOR Signaling Pathways in Cancer: New Data on Targeted Therapies
verfasst von: Lise Willems
Jerome Tamburini
Nicolas Chapuis
Catherine Lacombe
Patrick Mayeux
Didier Bouscary
Publikationsdatum: 01.04.2012
Verlag: Current Science Inc.
Erschienen in: Current Oncology Reports / Ausgabe 2/2012
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-012-0227-y

Springer Medizin

PI3K and mTOR Signaling Pathways in Cancer: New Data on Targeted Therapies

Abstract

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