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Current Rheumatology Reports

Erschienen in:

01.04.2010

Gout, Hyperuricemia, and the Risk of Cardiovascular Disease: Cause and Effect?

verfasst von: Ankoor Shah, Robert T. Keenan

Erschienen in: Current Rheumatology Reports | Ausgabe 2/2010

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Abstract

Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease. However, studies have frequently failed to distinguish whether these entities have an independent effect on cardiovascular risk or serve as markers for other risk factors. In vitro and animal studies suggest that uric acid is a biologically active compound that can increase inflammatory mediators known to lead to vascular damage. In contrast, uric acid also has potentially protective effects as a strong antioxidant, approaching the potency of vitamin C. Large clinical trials demonstrate a consistent relationship between elevated serum uric acid and a variety of cardiovascular diseases, although the strength of association varies greatly. We review the evidence for and against an independent role for hyperuricemia and/or gout in cardiovascular pathology.

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Titel: Gout, Hyperuricemia, and the Risk of Cardiovascular Disease: Cause and Effect?
verfasst von: Ankoor Shah
Robert T. Keenan
Publikationsdatum: 01.04.2010
Verlag: Current Science Inc.
Erschienen in: Current Rheumatology Reports / Ausgabe 2/2010
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-010-0084-3

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