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Current Rheumatology Reports
Erschienen in: Current Rheumatology Reports 5/2013

01.05.2013 | ANTIPHOSPHOLIPID SYNDROME (RAS ROUBEY, SECTION EDITOR)

Inhibition of Nitric Oxide and Antiphospholipid Antibody-Mediated Thrombosis

verfasst von: Chieko Mineo

Erschienen in: Current Rheumatology Reports | Ausgabe 5/2013

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Abstract

The antiphospholipid syndrome (APS) is characterized by recurrent vascular thrombosis, thrombocytopenia, and fetal loss occurring in the presence of antiphospholipid antibodies (aPL). Along with arterial and venous thrombosis and pregnancy complications, patients with APS have an increased risk of myocardial infarction, stroke, and coronary artery disease, resulting from vascular cell dysfunction induced by aPL. Accumulating evidence to date indicates that interactions between circulating aPL and cell surface molecules of target cells, primarily endothelial cells and platelets, underlie the vascular disease phenotypes of APS. However, the molecular basis of APS is poorly understood. Nitric oxide produced by endothelial cells is a key determinant of vascular health that regulates several physiologic processes, including thrombosis, endothelial-leukocyte interaction, vascular cell migration, and the modulation of vascular tone. This review will discuss recent findings that indicate a novel mechanism by which aPL antagonize endothelial cell production of nitric oxide and thereby promote thrombosis.
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Metadaten
Titel
Inhibition of Nitric Oxide and Antiphospholipid Antibody-Mediated Thrombosis
verfasst von
Chieko Mineo
Publikationsdatum
01.05.2013
Verlag
Current Science Inc.
Erschienen in
Current Rheumatology Reports / Ausgabe 5/2013
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-013-0324-4

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