Erschienen in:
01.08.2014 | VASCULITIS (LR ESPINOZA, SECTION EDITOR)
Treatment of Severe and/or Refractory ANCA-Associated Vasculitis
verfasst von:
Loïc Guillevin
Erschienen in:
Current Rheumatology Reports
|
Ausgabe 8/2014
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Abstract
Most patients presenting with systemic necrotizing vasculitides improve when they are adequately treated. The presence of life-threatening manifestations or visceral involvement modifying organ function characterizes severe vasculitis, confirmed by disease-severity scores. Sequelae cannot always be predicted and prevented but organ involvement present at disease onset requires rapid therapeutic intervention. Some patients present a persistent active disease, which does not respond to treatments and deserve other drugs or combination of drugs. The therapeutic options for severe and/or relapsing and refractory diseases are described.