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Current Rheumatology Reports

Erschienen in:

01.05.2016 | Crystal Arthritis (MH Pillinger and SK Samuels, Section Editors)

The Role of ANK in Calcium Pyrophosphate Deposition Disease

verfasst von: Elizabeth Mitton-Fitzgerald, Claudia M. Gohr, Brittany Bettendorf, Ann K. Rosenthal

Erschienen in: Current Rheumatology Reports | Ausgabe 5/2016

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Abstract

The protein product of the progressive ankylosis gene, known as ANK, is a 492-amino acid multi-pass transmembrane protein. This protein is critical for the regulation of pyrophosphate, and gain of function ANK mutations is associated with calcium pyrophosphate deposition disease. Much about the structure, function, and regulation of ANK remain unstudied. This review of the current literature examines recent contributions to our understanding of ANK. We focus on new work on the function, binding partners, and regulators of ANK. A more complete understanding of this important protein may help to identify future therapeutic targets for the treatment of calcium pyrophosphate deposition disease.

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6.••

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Rosenthal AK et al. The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. Arthritis Res Ther. 2013;15(5):R154. This manuscript highlights a role for ANK in ATP transport. Using siRNA technology, ANK silencing led to decreased extracellular ATP. These findings were further supported by treatment of chondrocytes with probenecid, an ANK blocker.CrossRefPubMedPubMedCentral

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Gruber BL et al. Novel ANKH amino terminus mutation (Pro5Ser) associated with early-onset calcium pyrophosphate disease with associated phosphaturia. J Clin Rheumatol. 2012;18(4):192–5. This paper highlights yet another ANK mutation and its association with CPPD disease.PubMedPubMedCentral

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Tomaszewski KA et al. Degeneration and calcification of the cervical endplate is connected with decreased expression of ANK, ENPP-1, OPN and TGF-beta1 in the intervertebral disc. Pol J Pathol. 2014;65(3):210–7. This is a large scale immunohistochemistry study exploring the expression of ANK and ENPP1 in degenerated cervical discs.CrossRefPubMed

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28.••

Minashima T et al. The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes. Osteoarthritis Cartilage. 2014;22(6):852–61. This fascinating study explored new binding partners of ANK. The researchers also suggest another role for ANK beyond PPi transport.CrossRefPubMed

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Foster BL et al. Central role of pyrophosphate in acellular cementum formation. PLoS One. 2012;7(6):e38393. The role of ANK in Pi/PPi homeostasis was investigated. A feed-forward loop was established in which mineralization involves coordinate regulation of ANK and ENPP1.CrossRefPubMedPubMedCentral

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Titel: The Role of ANK in Calcium Pyrophosphate Deposition Disease
verfasst von: Elizabeth Mitton-Fitzgerald
Claudia M. Gohr
Brittany Bettendorf
Ann K. Rosenthal
Publikationsdatum: 01.05.2016
Verlag: Springer US
Erschienen in: Current Rheumatology Reports / Ausgabe 5/2016
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI: https://doi.org/10.1007/s11926-016-0574-z

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