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Clinical Orthopaedics and Related Research®

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01.09.2009 | Case Report

Case Report: Kaposiform Hemangioendothelioma in Multiple Spinal Levels Without Skin Changes

verfasst von: Jennifer W. Lisle, MD, Heather A. Bradeen, MD, Alexandra N. Kalof, MD

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 9/2009

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Abstract

Kaposiform hemangioendothelioma is a rare vascular tumor of childhood that is locally aggressive but has little metastatic potential and by itself is not known to be lethal. It most commonly presents as a superficial or deep soft tissue mass with associated cutaneous lesions. Kasabach-Merritt phenomenon, a condition characterized by profound thrombocytopenia and life-threatening hemorrhage, often is associated with kaposiform hemangioendothelioma. Six cases of kaposiform hemangioendothelioma have been reported in bone, two of which were located in extracraniofacial bones. We report a diagnostically challenging case of a 6-year-old girl with kaposiform hemangioendothelioma of the thoracolumbar spine without Kasabach-Merritt phenomenon or cutaneous lesions.

Beaubien ER, Ball NJ, Storwick GS. Kaposiform hemangioendothelioma: a locally aggressive vascular tumor. J Am Acad Dermatol. 1998;38:799–802.PubMedCrossRef

Bienaime A, Rojat-Habib MC, Hesse S, Pelissier JF, Bonerandi JJ. [Giant vascular tumour in an adult: tufted angioma or kaposiform hemangioendothelioma] [in French]. Ann Dermatol Venereol. 2006;133:553–556.PubMedCrossRef

Birchler MT, Schmid S, Holzmann D, Stallmach T, Gysin C. Kaposiform hemangioendothelioma arising in the ethmoid sinus of an 8-year-old girl with severe epistaxis. Head Neck. 2006;28:761–764.PubMedCrossRef

Blei F, Karp N, Rofsky N, Rosen R, Greco MA. Successful multimodal therapy for kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon: case report and review of the literature. Pediatr Hematol Oncol. 1998;15:295–305.PubMedCrossRef

Bodemer C, Fraitag S, Amoric JC, Benaceur S, Brunelle F, De Prost Y. [Spindle-cell hemangioendothelioma with monomelic and multifocal form in a child] [in French]. Ann Dermatol Venereol. 1997;124:857–860.PubMed

Bolde SA, Shete SS, Dantkale SS, Deshpande NM, Zawar MP. Kasabach-Merritt syndrome: a case report. Indian J Pathol Microbiol. 2005;48:27–29.PubMed

Brasanac D, Janic D, Boricic I, Jovanovic N, Dokmanovic L. Retroperitoneal kaposiform hemangioendothelioma with tufted angioma-like features in an infant with Kasabach-Merritt syndrome. Pathol Int. 2003;53:627–631.PubMedCrossRef

Chang JM, Kwon BJ, Han MH, Kang HS, Chang KH. Kaposiform hemangioendothelioma arising from the internal auditory canal. AJNR Am J Neuroradiol. 2006;27:931–933.PubMed

Chen RL, Chang PY, Hsu YH, Chang YH, Peng HC. Recurrent life-threatening hemothorax in an infant with pleurocutaneous kaposiform hemangio-endothelioma. J Pediatr Hematol Oncol. 2006;28:630–632.PubMedCrossRef

10.

Cheng YS, Kessler H, Rees TD, Philofsky D, Pontikas A. Gingival swelling in a 13-year-old girl with multiple recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:85–91.PubMedCrossRef

11.

Cho SH, Na KS. Haemangioendothelioma on the conjunctiva of the upper eyelid. Clin Experiment Ophthalmol. 2006;34:794–796.PubMedCrossRef

12.

Chung MT, Chen CH, Chiu CH, Yang CP, Hsueh C, Jaing TH. Successful nonoperative therapy for Kaposiform hemangioendothelioma involving the neck: report of 1 case. Otolaryngol Head Neck Surg. 2003;129:605–607.PubMedCrossRef

13.

Cooper JG, Edwards SL, Holmes JD. Kaposiform haemangioendothelioma: case report and review of the literature. Br J Plast Surg. 2002;55:163–165.PubMedCrossRef

14.

D’Amato RJ, Loughnan MS, Flynn E, Folkman J. Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA. 1994;91:4082–4085.PubMedCrossRef

15.

Deb G, Jenkner A, De Sio L, Boldrini R, Bosman C, Standoli N, Donfrancesco A. Spindle cell (Kaposiform) hemangioendothelioma with Kasabach-Merritt syndrome in an infant: successful treatment with alpha-2A interferon. Med Pediatr Oncol. 1997;28:358–361.PubMedCrossRef

16.

DeFatta RJ, Verret DJ, Adelson RT, Gomez A, Myers LL. Kaposiform hemangioendothelioma: case report and literature review. Laryngoscope. 2005;115:1789–1792.PubMedCrossRef

17.

Deraedt K, Vander Poorten V, Van Geet C, Renard M, De Wever I, Sciot R. Multifocal kaposiform haemangioendothelioma. Virchows Arch. 2006;448:843–846.PubMedCrossRef

18.

Ekfors TO, Kujari H, Herva R. Kaposi-like infantile hemangioendothelioma. Am J Surg Pathol. 1993;17:314–317.PubMed

19.

Enjolras O, Mulliken JB, Wassef M, Frieden IJ, Rieu PN, Burrows PE, Salhi A, Leaute-Labreze C, Kozakewich HP. Residual lesions after Kasabach-Merritt phenomenon in 41 patients. J Am Acad Dermatol. 2000;42:225–235.PubMedCrossRef

20.

Folkman J. Angiogenesis-dependent diseases. Semin Oncol. 2001;28:536–542.PubMedCrossRef

21.

Gianotti R, Gelmetti C, Alessi E. Congenital cutaneous multifocal kaposiform hemangioendothelioma. Am J Dermatopathol. 1999;21:557–561.PubMedCrossRef

22.

Gruman A, Liang MG, Mulliken JB, Fishman SJ, Burrows PE, Kozakewich HP, Blei F, Frieden IJ. Kaposiform hemangioendothelioma without Kasabach-Merritt phenomenon. J Am Acad Dermatol. 2005;52:616–622.PubMedCrossRef

23.

Haisley-Royster C, Enjolras O, Frieden IJ, Garzon M, Lee M, Oranje A, de Laat PC, Madern GC, Gonzalez F, Frangoul H, Le Moine P, Prose NS, Adams DM. Kasabach-Merritt phenomenon: a retrospective study of treatment with vincristine. J Pediatr Hematol Oncol. 2002;24:459–462.PubMedCrossRef

24.

Hardisson D, Prim MP, De Diego JI, Patron M, Escribano A, Rabanal I. Kaposiform hemangioendothelioma of the external auditory canal in an adult. Head Neck. 2002;24:614–617.PubMedCrossRef

25.

Harper L, Michel JL, Enjolras O, Raynaud-Mounet N, Riviere JP, Heigele T, De Napoli-Cocci S. Successful management of a retroperitoneal kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon using alpha-interferon. Eur J Pediatr Surg. 2006;16:369–372.PubMedCrossRef

26.

Hauer J, Graubner U, Konstantopoulos N, Schmidt S, Pfluger T, Schmid I. Effective treatment of kaposiform hemangioendotheliomas associated with Kasabach-Merritt phenomenon using four-drug regimen. Pediatr Blood Cancer. 2007;49:852–854.PubMedCrossRef

27.

Hsiao CC, Chen CC, Ko SF, Huang CC, Chuang JH. A case of axillary kaposiform hemangioendothelioma resembles a soft tissue sarcoma. J Pediatr Hematol Oncol. 2005;27:596–598.PubMedCrossRef

28.

Hu B, Lachman R, Phillips J, Peng SK, Sieger L. Kasabach-Merritt syndrome-associated kaposiform hemangioendothelioma successfully treated with cyclophosphamide, vincristine, and actinomycin D. J Pediatr Hematol Oncol. 1998;20:567–569.PubMedCrossRef

29.

Iwami D, Shimaoka S, Mochizuki I, Sakuma T. Kaposiform hemangioendothelioma of the mediastinum in a 7-month-old boy: a case report. J Pediatr Surg. 2006;41:1486–1488.PubMedCrossRef

30.

Kesari S, Schiff D, Henson JW, Muzikansky A, Gigas DC, Doherty L, Batchelor TT, Longtine JA, Ligon KL, Weaver S, Laforme A, Ramakrishna N, Black PM, Drappatz J, Ciampa A, Folkman J, Kieran M, Wen PY. Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro Oncol. 2008;10:300–308.PubMedCrossRef

31.

Lai FM, Allen PW, Yuen PM, Leung PC. Locally metastasizing vascular tumor: spindle cell, epithelioid, or unclassified hemangioendothelioma? Am J Clin Pathol. 1991;96:660–663.PubMed

32.

Lalaji TA, Haller JO, Burgess RJ. A case of head and neck kaposiform hemangioendothelioma simulating a malignancy on imaging. Pediatr Radiol. 2001;31:876–878.PubMedCrossRef

33.

Lee E, Billings SD, Roumpf S, Mousdicas N. Abdominal plaque in a 10-day-old boy. Arch Dermatol. 2006;142:641–646.

34.

Lyons LL, North PE, Mac-Moune Lai F, Stoler MH, Folpe AL, Weiss SW. Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangioma. Am J Surg Pathol. 2004;28:559–568.PubMed

35.

Mac-Moune Lai F, To KF, Choi PC, Leung PC, Kumta SM, Yuen PP, Lam WY, Cheung AN, Allen PW. Kaposiform hemangioendothelioma: five patients with cutaneous lesion and long follow-up. Mod Pathol. 2001;14:1087–1092.PubMedCrossRef

36.

Martinez AE, Robinson MJ, Alexis JB. Kaposiform hemangioendothelioma associated with nonimmune fetal hydrops. Arch Pathol Lab Med. 2004;128:678–681.PubMed

37.

Mendez R, Capdevila A, Tellado MG, Somoza I, Liras J, Pais E, Vela D. Kaposiform hemangioendothelioma associated with Milroy’s disease (primary hereditary lymphedema). J Pediatr Surg. 2003;38:E9–E12.PubMedCrossRef

38.

Mentzel T, Mazzoleni G, Dei Tos AP, Fletcher CD. Kaposiform hemangioendothelioma in adults: clinicopathologic and immunohistochemical analysis of three cases. Am J Clin Pathol. 1997;108:450–455.PubMed

39.

Niedt GW, Greco MA, Wieczorek R, Blanc WA, Knowles DM 2nd. Hemangioma with Kaposi’s sarcoma-like features: report of two cases. Pediatr Pathol. 1989;9:567–575.PubMedCrossRef

40.

San Miguel FL, Spurbeck W, Budding C, Horton J. Kaposiform hemangioendothelioma: a rare cause of spontaneous hemothorax in infancy. Review of the literature. J Pediatr Surg. 2008;43:e37–e41.PubMedCrossRef

41.

Sarkar M, Mulliken JB, Kozakewich HP, Robertson RL, Burrows PE. Thrombocytopenic coagulopathy (Kasabach-Merritt phenomenon) is associated with Kaposiform hemangioendothelioma and not with common infantile hemangioma. Plast Reconstr Surg. 1997;100:1377–1386.PubMedCrossRef

42.

Senturk N, Yyldiz L, Aydin F, Eroglu L, Canturk T, Turanli AY. Kaposiform hemangioendothelioma in an adult with an unusual presentation. J Eur Acad Dermatol Venereol. 2006;20:630–632.PubMedCrossRef

43.

Vetter-Kauczok CS, Strobel P, Brocker EB, Becker JC. Kaposiform hemangioendothelioma with distant lymphangiomatosis without an association to Kasabach-Merritt-Syndrome in a female adult! Vasc Health Risk Manag. 2008;4:263–266.PubMedCrossRef

44.

Weiss SW, Goldblum JR, eds. Hemangioendothelioma: vascular tumors of intermediate malignancy. Enzinger and Weiss’s Soft Tissue Tumors. 5th Ed. St Louis, MO: Mosby Elsevier; 2008, pp. 688–693.

45.

Wilken JJ, Meier FA, Kornstein MJ. Kaposiform hemangioendothelioma of the thymus. Arch Pathol Lab Med. 2000;124:1542–1544.PubMed

46.

Zamecnik M, Mikleova Z, Michal M. Kaposiform hemangioendothelioma in adult: report of a case with amianthoid-like fibrosis and angiectases. Cesk Patol. 2000;36:163–167.PubMed

47.

Zukerberg LR, Nickoloff BJ, Weiss SW. Kaposiform hemangioendothelioma of infancy and childhood: an aggressive neoplasm associated with Kasabach-Merritt syndrome and lymphangiomatosis. Am J Surg Pathol. 1993;17:321–328.PubMedCrossRef

Titel: Case Report: Kaposiform Hemangioendothelioma in Multiple Spinal Levels Without Skin Changes
verfasst von: Jennifer W. Lisle, MD
Heather A. Bradeen, MD
Alexandra N. Kalof, MD
Publikationsdatum: 01.09.2009
Verlag: Springer-Verlag
Erschienen in: Clinical Orthopaedics and Related Research® / Ausgabe 9/2009
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-009-0838-2

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