Skip to main content
Erschienen in: Clinical Orthopaedics and Related Research® 9/2013

01.09.2013 | Symposium: Tscherne Festschrift

Do Parameters Used to Clear Noncritically Injured Polytrauma Patients for Extremity Surgery Predict Complications?

verfasst von: Thomas Dienstknecht, MD, Dieter Rixen, MD, Peter Giannoudis, MD, Hans-Christoph Pape, MD, the EPOFF Study Group

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 9/2013

Einloggen, um Zugang zu erhalten

Abstract

Background

In multiply injured patients, definitive stabilization of major fractures is performed whenever feasible, depending on the clinical condition.

Questions/purposes

We therefore asked whether (1) any preoperative indicators predict major complications after major extremity surgery; (2) perioperative routine parameters other than those indicative of hemorrhagic shock predict postoperative complications; and (3) any postoperative clinical findings can predict major complications in the further course of the patient.

Methods

We prospectively followed patients with femoral midshaft fracture, Injury Severity Score (ISS) > 16 points, or three fractures and Abbreviated Injury Scale (AIS) ≥ 2 points and another injury (AIS ≥ 2 points), and age 18 to 65 years. We recorded multiple clinical parameters. End points were pneumonia, sepsis, acute respiratory distress syndrome, acute lung injury, and multiple organ failure.

Results

Forty-three of 165 patients developed complications. (1) Patients with complications had a decreased initial Glasgow Coma Scale and tended to have a lower ISS. (2) None of the assessed perioperative parameters was able to sufficiently predict postoperative complications. (3) The presence of a lung contusion and ventilation > 48 hours were associated with complications in the further course.

Conclusions

In stable multiply injured patients, none of the individual routine clinical parameters was able to predict complications. Severe head and thoracic injuries seem to be important drivers for the development postoperative complications.

Level of Evidence

Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.
Literatur
1.
Zurück zum Zitat Asensio JA, McDuffie L, Petrone P, Roldan G, Forno W, Gambaro E, Salim A, Demetriades D, Murray J, Velmahos G, Shoemaker W, Berne TV, Ramicone E, Chan L. Reliable variables in the exsanguinated patient which indicate damage control and predict outcome. Am J Surg. 2001;182:743–751.PubMedCrossRef Asensio JA, McDuffie L, Petrone P, Roldan G, Forno W, Gambaro E, Salim A, Demetriades D, Murray J, Velmahos G, Shoemaker W, Berne TV, Ramicone E, Chan L. Reliable variables in the exsanguinated patient which indicate damage control and predict outcome. Am J Surg. 2001;182:743–751.PubMedCrossRef
2.
Zurück zum Zitat Ba ZF, Wang P, Koo DJ, Cioffi WG, Bland KI, Chaudry IH. Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock. Crit Care Med. 2000;28:2837–2842.PubMedCrossRef Ba ZF, Wang P, Koo DJ, Cioffi WG, Bland KI, Chaudry IH. Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock. Crit Care Med. 2000;28:2837–2842.PubMedCrossRef
3.
Zurück zum Zitat Baker SP, O’Neill B, Haddon W Jr, Long WB. The Injury Severity Score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974;14:187–196.PubMedCrossRef Baker SP, O’Neill B, Haddon W Jr, Long WB. The Injury Severity Score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974;14:187–196.PubMedCrossRef
4.
Zurück zum Zitat Balogh ZJ, Varga E, Tomka J, Suveges G, Toth L, Simonka JA. The New Injury Severity Score is a better predictor of extended hospitalization and intensive care unit admission than the Injury Severity Score in patients with multiple orthopaedic injuries. J Orthop Trauma. 2003;17:508–512.PubMedCrossRef Balogh ZJ, Varga E, Tomka J, Suveges G, Toth L, Simonka JA. The New Injury Severity Score is a better predictor of extended hospitalization and intensive care unit admission than the Injury Severity Score in patients with multiple orthopaedic injuries. J Orthop Trauma. 2003;17:508–512.PubMedCrossRef
5.
Zurück zum Zitat Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149:818–824.PubMedCrossRef Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149:818–824.PubMedCrossRef
6.
Zurück zum Zitat Butcher NE, Balogh ZJ. The practicality of including the systemic inflammatory response syndrome in the definition of polytrauma: experience of a level one trauma centre. Injury. 2012;33:23–29. Butcher NE, Balogh ZJ. The practicality of including the systemic inflammatory response syndrome in the definition of polytrauma: experience of a level one trauma centre. Injury. 2012;33:23–29.
7.
Zurück zum Zitat Champion HR, Sacco WJ, Copes WS, Gann DS, Gennarelli TA, Flanagan ME. A revision of the Trauma Score. J Trauma. 1989;29:623–629.PubMedCrossRef Champion HR, Sacco WJ, Copes WS, Gann DS, Gennarelli TA, Flanagan ME. A revision of the Trauma Score. J Trauma. 1989;29:623–629.PubMedCrossRef
8.
Zurück zum Zitat Della Rocca GJ, Crist BD. External fixation versus conversion to intramedullary nailing for definitive management of closed fractures of the femoral and tibial shaft. J Am Acad Orthop Surg. 2006;14:S131–135. Della Rocca GJ, Crist BD. External fixation versus conversion to intramedullary nailing for definitive management of closed fractures of the femoral and tibial shaft. J Am Acad Orthop Surg. 2006;14:S131–135.
9.
Zurück zum Zitat Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF. Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. Crit Care Med. 2000;28:125–131.PubMedCrossRef Eberhard LW, Morabito DJ, Matthay MA, Mackersie RC, Campbell AR, Marks JD, Alonso JA, Pittet JF. Initial severity of metabolic acidosis predicts the development of acute lung injury in severely traumatized patients. Crit Care Med. 2000;28:125–131.PubMedCrossRef
10.
Zurück zum Zitat Esme H, Solak O, Yurumez Y, Yavuz Y, Terzi Y, Sezer M, Kucuker H. The prognostic importance of trauma scoring systems for blunt thoracic trauma. Thorac Cardiovasc Surg. 2007;55:190–195.PubMedCrossRef Esme H, Solak O, Yurumez Y, Yavuz Y, Terzi Y, Sezer M, Kucuker H. The prognostic importance of trauma scoring systems for blunt thoracic trauma. Thorac Cardiovasc Surg. 2007;55:190–195.PubMedCrossRef
11.
Zurück zum Zitat Frith D, Brohi K. The acute coagulopathy of trauma shock: clinical relevance. Surgeon. 2010;8:159–163.PubMedCrossRef Frith D, Brohi K. The acute coagulopathy of trauma shock: clinical relevance. Surgeon. 2010;8:159–163.PubMedCrossRef
12.
Zurück zum Zitat Gando S, Nanzaki S, Kemmotsu O. Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ dysfunctions after trauma: application of clinical decision analysis. Ann Surg. 1999;229:121–127.PubMedCrossRef Gando S, Nanzaki S, Kemmotsu O. Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ dysfunctions after trauma: application of clinical decision analysis. Ann Surg. 1999;229:121–127.PubMedCrossRef
13.
Zurück zum Zitat Gurd AR. Fat embolism: an aid to diagnosis. J Bone Joint Surg Br. 1970;52:732–737.PubMed Gurd AR. Fat embolism: an aid to diagnosis. J Bone Joint Surg Br. 1970;52:732–737.PubMed
14.
Zurück zum Zitat Handolin L, Pajarinen J, Lassus J, Tulikoura I. Early intramedullary nailing of lower extremity fracture and respiratory function in polytraumatized patients with a chest injury: a retrospective study of 61 patients. Acta Orthop Scand. 2004;75:477–480.PubMedCrossRef Handolin L, Pajarinen J, Lassus J, Tulikoura I. Early intramedullary nailing of lower extremity fracture and respiratory function in polytraumatized patients with a chest injury: a retrospective study of 61 patients. Acta Orthop Scand. 2004;75:477–480.PubMedCrossRef
15.
Zurück zum Zitat Husebye EE, Lyberg T, Opdahl H, Aspelin T, Stoen RO, Madsen JE, Roise O. Intramedullary nailing of femoral shaft fractures in polytraumatized patients. a longitudinal, prospective and observational study of the procedure-related impact on cardiopulmonary- and inflammatory responses. Scand J Trauma Resusc Emerg Med. 2012;20:2. Husebye EE, Lyberg T, Opdahl H, Aspelin T, Stoen RO, Madsen JE, Roise O. Intramedullary nailing of femoral shaft fractures in polytraumatized patients. a longitudinal, prospective and observational study of the procedure-related impact on cardiopulmonary- and inflammatory responses. Scand J Trauma Resusc Emerg Med. 2012;20:2.
16.
Zurück zum Zitat Johnson EE, Matta JM, Mast JW, Letournel E. Delayed reconstruction of acetabular fractures 21–120 days following injury. Clin Orthop Relat Res. 1994;305:20–30.PubMed Johnson EE, Matta JM, Mast JW, Letournel E. Delayed reconstruction of acetabular fractures 21–120 days following injury. Clin Orthop Relat Res. 1994;305:20–30.PubMed
17.
Zurück zum Zitat Mikhail J. The trauma triad of death: hypothermia, acidosis, and coagulopathy. AACN Clin Issues. 1999;10:85–94.PubMedCrossRef Mikhail J. The trauma triad of death: hypothermia, acidosis, and coagulopathy. AACN Clin Issues. 1999;10:85–94.PubMedCrossRef
18.
Zurück zum Zitat Moore FA, Moore EE, Poggetti R, McAnena OJ, Peterson VM, Abernathy CM, Parsons PE. Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma. J Trauma. 1991;31:629–636; discussion 636–638. Moore FA, Moore EE, Poggetti R, McAnena OJ, Peterson VM, Abernathy CM, Parsons PE. Gut bacterial translocation via the portal vein: a clinical perspective with major torso trauma. J Trauma. 1991;31:629–636; discussion 636–638.
19.
Zurück zum Zitat Nast-Kolb D, Waydhas C, Gippner-Steppert C, Schneider I, Trupka A, Ruchholtz S, Zettl R, Schweiberer L, Jochum M. Indicators of the posttraumatic inflammatory response correlate with organ failure in patients with multiple injuries. J Trauma. 1997;42:446–454; discussion 454–455. Nast-Kolb D, Waydhas C, Gippner-Steppert C, Schneider I, Trupka A, Ruchholtz S, Zettl R, Schweiberer L, Jochum M. Indicators of the posttraumatic inflammatory response correlate with organ failure in patients with multiple injuries. J Trauma. 1997;42:446–454; discussion 454–455.
20.
Zurück zum Zitat Nicholas B, Toth L, van Wessem K, Evans J, Enninghorst N, Balogh ZJ. Borderline femur fracture patients: early total care or damage control orthopaedics? ANZ J Surg. 2011;81:148–153.PubMedCrossRef Nicholas B, Toth L, van Wessem K, Evans J, Enninghorst N, Balogh ZJ. Borderline femur fracture patients: early total care or damage control orthopaedics? ANZ J Surg. 2011;81:148–153.PubMedCrossRef
21.
Zurück zum Zitat Osler T, Baker SP, Long W. A modification of the Injury Severity Score that both improves accuracy and simplifies scoring. J Trauma. 1997;43:922–925; discussion 925–926. Osler T, Baker SP, Long W. A modification of the Injury Severity Score that both improves accuracy and simplifies scoring. J Trauma. 1997;43:922–925; discussion 925–926.
22.
Zurück zum Zitat Pape HC, Giannoudis PV, Krettek C, Trentz O. Timing of fixation of major fractures in blunt polytrauma: role of conventional indicators in clinical decision making. J Orthop Trauma. 2005;19:551–562.PubMedCrossRef Pape HC, Giannoudis PV, Krettek C, Trentz O. Timing of fixation of major fractures in blunt polytrauma: role of conventional indicators in clinical decision making. J Orthop Trauma. 2005;19:551–562.PubMedCrossRef
23.
Zurück zum Zitat Pape HC, Hildebrand F, Pertschy S, Zelle B, Garapati R, Grimme K, Krettek C, Reed RL 2nd. Changes in the management of femoral shaft fractures in polytrauma patients: from early total care to damage control orthopedic surgery. J Trauma. 2002;53:452–461; discussion 461–462. Pape HC, Hildebrand F, Pertschy S, Zelle B, Garapati R, Grimme K, Krettek C, Reed RL 2nd. Changes in the management of femoral shaft fractures in polytrauma patients: from early total care to damage control orthopedic surgery. J Trauma. 2002;53:452–461; discussion 461–462.
24.
Zurück zum Zitat Pape HC, Remmers D, Rice J, Ebisch M, Krettek C, Tscherne H. Appraisal of early evaluation of blunt chest trauma: development of a standardized scoring system for initial clinical decision making. J Trauma. 2000;49:496–504.PubMedCrossRef Pape HC, Remmers D, Rice J, Ebisch M, Krettek C, Tscherne H. Appraisal of early evaluation of blunt chest trauma: development of a standardized scoring system for initial clinical decision making. J Trauma. 2000;49:496–504.PubMedCrossRef
25.
Zurück zum Zitat Pape HC, Rixen D, Morley J, Husebye EE, Mueller M, Dumont C, Gruner A, Oestern HJ, Bayeff-Filoff M, Garving C, Pardini D, van Griensven M, Krettek C, Giannoudis P. Impact of the method of initial stabilization for femoral shaft fractures in patients with multiple injuries at risk for complications (borderline patients). Ann Surg. 2007;246:491–499; discussion 499–501. Pape HC, Rixen D, Morley J, Husebye EE, Mueller M, Dumont C, Gruner A, Oestern HJ, Bayeff-Filoff M, Garving C, Pardini D, van Griensven M, Krettek C, Giannoudis P. Impact of the method of initial stabilization for femoral shaft fractures in patients with multiple injuries at risk for complications (borderline patients). Ann Surg. 2007;246:491–499; discussion 499–501.
26.
Zurück zum Zitat Parks JK, Elliott AC, Gentilello LM, Shafi S. Systemic hypotension is a late marker of shock after trauma: a validation study of Advanced Trauma Life Support principles in a large national sample. Am J Surg. 2006;192:727–731.PubMedCrossRef Parks JK, Elliott AC, Gentilello LM, Shafi S. Systemic hypotension is a late marker of shock after trauma: a validation study of Advanced Trauma Life Support principles in a large national sample. Am J Surg. 2006;192:727–731.PubMedCrossRef
27.
Zurück zum Zitat Pohlemann T, Culemann U, Gansslen A, Tscherne H. [Severe pelvic injury with pelvic mass hemorrhage: determining severity of hemorrhage and clinical experience with emergency stabilization] [in German]. Unfallchirurg. 1996;99:734–743.PubMedCrossRef Pohlemann T, Culemann U, Gansslen A, Tscherne H. [Severe pelvic injury with pelvic mass hemorrhage: determining severity of hemorrhage and clinical experience with emergency stabilization] [in German]. Unfallchirurg. 1996;99:734–743.PubMedCrossRef
28.
Zurück zum Zitat Radvinsky DS, Yoon RS, Schmitt PJ, Prestigiacomo CJ, Swan KG, Liporace FA. Evolution and development of the Advanced Trauma Life Support (ATLS) protocol: a historical perspective. Orthopedics. 2012;35:305–311.PubMedCrossRef Radvinsky DS, Yoon RS, Schmitt PJ, Prestigiacomo CJ, Swan KG, Liporace FA. Evolution and development of the Advanced Trauma Life Support (ATLS) protocol: a historical perspective. Orthopedics. 2012;35:305–311.PubMedCrossRef
29.
Zurück zum Zitat Society COT. Reamed versus unreamed intramedullary nailing of the femur: comparison of the rate of ARDS in multiple injured patients. J Orthop Trauma. 2006;20:384–387.CrossRef Society COT. Reamed versus unreamed intramedullary nailing of the femur: comparison of the rate of ARDS in multiple injured patients. J Orthop Trauma. 2006;20:384–387.CrossRef
30.
31.
Zurück zum Zitat Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974;2:81–84.CrossRef Teasdale G, Jennett B. Assessment of coma and impaired consciousness. A practical scale. Lancet. 1974;2:81–84.CrossRef
32.
Zurück zum Zitat Trentz O, Oestern HJ, Hempelmann G, Kolbow H, Sturm J, Trentz OA, Tscherne H. [Criteria for the operability of patients with multiple injuries (author’s transl)] [in German]. Unfallheilkunde. 1978;81:451–458.PubMed Trentz O, Oestern HJ, Hempelmann G, Kolbow H, Sturm J, Trentz OA, Tscherne H. [Criteria for the operability of patients with multiple injuries (author’s transl)] [in German]. Unfallheilkunde. 1978;81:451–458.PubMed
33.
Zurück zum Zitat Tyburski JG, Collinge JD, Wilson RF, Carlin AM, Albaran RG, Steffes CP. End-tidal CO2-derived values during emergency trauma surgery correlated with outcome: a prospective study. J Trauma. 2002;53:738–743.PubMedCrossRef Tyburski JG, Collinge JD, Wilson RF, Carlin AM, Albaran RG, Steffes CP. End-tidal CO2-derived values during emergency trauma surgery correlated with outcome: a prospective study. J Trauma. 2002;53:738–743.PubMedCrossRef
34.
Zurück zum Zitat Tyburski JG, Collinge JD, Wilson RF, Eachempati SR. Pulmonary contusions: quantifying the lesions on chest X-ray films and the factors affecting prognosis. J Trauma. 1999;46:833–838.PubMedCrossRef Tyburski JG, Collinge JD, Wilson RF, Eachempati SR. Pulmonary contusions: quantifying the lesions on chest X-ray films and the factors affecting prognosis. J Trauma. 1999;46:833–838.PubMedCrossRef
35.
Zurück zum Zitat van Griensven M, Kuzu M, Breddin M, Bottcher F, Krettek C, Pape HC, Tschernig T. Polymicrobial sepsis induces organ changes due to granulocyte adhesion in a murine two hit model of trauma. Exp Toxicol Pathol. 2002;54:203–209.PubMedCrossRef van Griensven M, Kuzu M, Breddin M, Bottcher F, Krettek C, Pape HC, Tschernig T. Polymicrobial sepsis induces organ changes due to granulocyte adhesion in a murine two hit model of trauma. Exp Toxicol Pathol. 2002;54:203–209.PubMedCrossRef
36.
Zurück zum Zitat van Os JP, Roumen RM, Schoots FJ, Heystraten FM, Goris RJ. Is early osteosynthesis safe in multiple trauma patients with severe thoracic trauma and pulmonary contusion? J Trauma. 1994;36:495–498.PubMedCrossRef van Os JP, Roumen RM, Schoots FJ, Heystraten FM, Goris RJ. Is early osteosynthesis safe in multiple trauma patients with severe thoracic trauma and pulmonary contusion? J Trauma. 1994;36:495–498.PubMedCrossRef
37.
Zurück zum Zitat Velmahos GC, Chan L, Chan M, Tatevossian R, Cornwell EE 3rd, Asensio JA, Berne TV, Demetriades D. Is there a limit to massive blood transfusion after severe trauma? Arch Surg. 1998;133:947–952.PubMedCrossRef Velmahos GC, Chan L, Chan M, Tatevossian R, Cornwell EE 3rd, Asensio JA, Berne TV, Demetriades D. Is there a limit to massive blood transfusion after severe trauma? Arch Surg. 1998;133:947–952.PubMedCrossRef
38.
Zurück zum Zitat Veysi VT, Nikolaou VS, Paliobeis C, Efstathopoulos N, Giannoudis PV. Prevalence of chest trauma, associated injuries and mortality: a level I trauma centre experience. Int Orthop. 2009;33:1425–1433.PubMedCrossRef Veysi VT, Nikolaou VS, Paliobeis C, Efstathopoulos N, Giannoudis PV. Prevalence of chest trauma, associated injuries and mortality: a level I trauma centre experience. Int Orthop. 2009;33:1425–1433.PubMedCrossRef
39.
Zurück zum Zitat Weckbach S, Perl M, Heiland T, Braumuller S, Stahel PF, Flierl MA, Ignatius A, Gebhard F, Huber-Lang M. A new experimental polytrauma model in rats: molecular characterization of the early inflammatory response. Mediators Inflamm. 2012;2012:890816.PubMedCrossRef Weckbach S, Perl M, Heiland T, Braumuller S, Stahel PF, Flierl MA, Ignatius A, Gebhard F, Huber-Lang M. A new experimental polytrauma model in rats: molecular characterization of the early inflammatory response. Mediators Inflamm. 2012;2012:890816.PubMedCrossRef
40.
Zurück zum Zitat Yucel N, Lefering R, Maegele M, Vorweg M, Tjardes T, Ruchholtz S, Neugebauer EA, Wappler F, Bouillon B, Rixen D. Trauma Associated Severe Hemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma. J Trauma. 2006;60:1228–1236; discussion 1236–1237. Yucel N, Lefering R, Maegele M, Vorweg M, Tjardes T, Ruchholtz S, Neugebauer EA, Wappler F, Bouillon B, Rixen D. Trauma Associated Severe Hemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma. J Trauma. 2006;60:1228–1236; discussion 1236–1237.
Metadaten
Titel
Do Parameters Used to Clear Noncritically Injured Polytrauma Patients for Extremity Surgery Predict Complications?
verfasst von
Thomas Dienstknecht, MD
Dieter Rixen, MD
Peter Giannoudis, MD
Hans-Christoph Pape, MD
the EPOFF Study Group
Publikationsdatum
01.09.2013
Verlag
Springer US
Erschienen in
Clinical Orthopaedics and Related Research® / Ausgabe 9/2013
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-013-2924-8

Weitere Artikel der Ausgabe 9/2013

Clinical Orthopaedics and Related Research® 9/2013 Zur Ausgabe

Symposium: Tscherne Festschrift

Trauma Care in India and Germany

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.