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01.04.2016

Protective Effect of Hydroxytyrosol Against Cardiac Remodeling After Isoproterenol-Induced Myocardial Infarction in Rat

verfasst von: Kais Mnafgui, Raouf Hajji, Fatma Derbali, Ines Khlif, Ftouma Kraiem, Hedi Ellefi, Abdelfattah Elfeki, Noureddine Allouche, Neji Gharsallah

Erschienen in: Cardiovascular Toxicology | Ausgabe 2/2016

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Abstract

The present study aimed to investigate the cardioprotective effect of hydroxytyrosol (HT) against isoproterenol-induced myocardial infarction in rats. Male rats were randomly divided into four groups, control, isoproterenol (Isop) and pretreated animals with HT in two different doses (2 and 5 mg/kg) orally for 7 days and intoxicated with isoproterenol (Isop + HT1) and (Isop + HT2) groups. Myocardial infarction in rats was induced subcutaneously by isoproterenol (100 mg/kg, s.c.) at an interval of 24 h on 6th and 7th day. On 8th day, electrocardiographic (ECG) pattern, gravimetric and biochemical parameters were assessed. Isoproterenol exhibited changes in ECG pattern, including significant ST-segment elevation and increase in the serum troponin-T level by 317 % as compared to control rats. Moreover, cardiac injury markers (creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase) underwent a notable rise in serum of infarcted animals. Else, a disturbance in lipids profile and significant increase in lipase and angiotensin-converting enzyme (ACE) activities and heart weight ratio were observed in isoproterenol group. However, pre- and co-treatment with HT (2 and 5 mg/kg) improved the myocardium injury, restored the hemodynamic function and inhibited the ACE activity that prevent cardiac hypertrophy and remodeling. Overall, these findings demonstrated that HT exerted a potent cardioprotective effect against isoproterenol-induced myocardial infarction.

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Titel: Protective Effect of Hydroxytyrosol Against Cardiac Remodeling After Isoproterenol-Induced Myocardial Infarction in Rat
verfasst von: Kais Mnafgui
Raouf Hajji
Fatma Derbali
Ines Khlif
Ftouma Kraiem
Hedi Ellefi
Abdelfattah Elfeki
Noureddine Allouche
Neji Gharsallah
Publikationsdatum: 01.04.2016
Verlag: Springer US
Erschienen in: Cardiovascular Toxicology / Ausgabe 2/2016
Print ISSN: 1530-7905
Elektronische ISSN: 1559-0259
DOI: https://doi.org/10.1007/s12012-015-9323-1

Springer Medizin

Abstract

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