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Endocrine

Erschienen in:

01.10.2012 | Mini Review

Andrological aspects of physical exercise and sport medicine

verfasst von: Luigi Di Luigi, Francesco Romanelli, Paolo Sgrò, Andrea Lenzi

Erschienen in: Endocrine | Ausgabe 2/2012

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Abstract

Appropriate physical activity is one of the bases of healthy lifestyle. In fact, physical exercise and playing sport may be associated with both improvements and injury to both general and reproductive health. A biologically normal testosterone secretion appears fundamental in males to guarantee both a physiological exercise adaptation and safe sport participation. The reproductive system is highly sensitive to the effects of exercise-related stress and the reproductive hormones may both increase and decrease after different acute or chronic exercises. Exercise and sport participation may positively or negatively influence andrological health status depending on the type, intensity and duration of performed physical activity and on individual health status. In addition, prohibited substances administration (e.g. androgenic–anabolic steroids, and so forth) in competitive and non-competitive athletes represents the main cause of iatrogenic andrological diseases. Preventing and treating andrological problems in active healthy and unhealthy individuals is as important as promoting a correct lifestyle. Physicians need to be educated on the relationships between the male reproductive system and sport participation and on the great role of the pre-participation physical examination in the prevention of andrological diseases.

A.C. Hackney, Stress and the neuroendocrine system: the role of exercise as a stressor and modifier of stress. Expert Rev. Endocrinol. Metab. 1, 783–792 (2006)PubMedCrossRef

S. Hasani-Ranjbar, E. Soleymani Far, R. Heshmat, H. Rajabi, H. Kosari, Time course responses of serum GH, insulin, IGF-1, IGFBP1, and IGFBP3 concentrations after heavy resistance exercise in trained and untrained men. Endocrine 41, 144–151 (2012)PubMedCrossRef

M. Zitzmann, Effects of testosterone replacement and its pharmacogenetics on physical performance and metabolism. Asian J. Androl. 10, 364–372 (2008)PubMedCrossRef

S. Bhasin, L. Woodhouse, R. Casaburi, A.B. Singh, D. Bhasin, N. Berman, X. Chen, K.E. Yarasheski, L. Magliano, C. Dzekov, J. Dzekov, R. Bross, J. Phillips, I. Sinha-Hikim, R. Shen, T.W. Storer, Testosterone dose-response relationships in healthy young men. Am. J. Physiol. Endocrinol. Metab. 281, E1172–E1181 (2001)PubMed

B.T. Crewther, C. Cook, M. Cardinale, R.P. Weatherby, T. Lowe, Two emerging concepts for elite athletes: the short-term effects of testosterone and cortisol on the neuromuscular system and the dose-response training role of these endogenous hormones. Sports Med. 41, 103–123 (2011)PubMedCrossRef

L. Di Luigi, C. Baldari, M. Gallotta, F. Perroni, F. Romanelli, A. Lenzi, L. Guidetti, Salivary steroids at rest and after a training load in young male athletes: relationship with chronological age and pubertal development. Int. J. Sports Med. 27, 709–717 (2006)PubMedCrossRef

G.F. Gonzales, V. Tapia, M. Gasco, J. Rubio, C. Gonzales-Castañeda, High serum zinc and serum testosterone levels were associated with excessive erythrocytosis in men at high altitudes. Endocrine 40, 472–480 (2011)PubMedCrossRef

A.M. Isidori, E. Giannetta, E.A. Greco, D. Gianfrilli, V. Bonifacio, A. Isidori, A. Lenzi, A. Fabbri, Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin. Endocrinol. 63, 280–293 (2005)CrossRef

E. Nieschlag, H.M. Behre, P. Bouchard, J.J. Corrales, T.H. Jones, G.K. Stalla, S.M. Webb, F.C. Wu, Testosterone replacement therapy: current trend and future directions. Hum. Reprod. Update 10, 409–419 (2004)PubMedCrossRef

10.

R. Timon, G. Olcina, P. Tomas-Carus, A. Raimundo, J.I. Maynar, M. Maynar, Urinary endogenous steroids and their relationships with BMD and body composition in healthy young males. Endocrine. (2012). doi:10.1007/s12020-012-9604-4

11.

M. Zitzmann, E. Nieschlag, Effects of androgen replacement on metabolism and physical performances in male hypogonadism. J. Endocrinol. Invest. 26, 886–892 (2003)PubMed

12.

B. Crewther, J. Keogh, J. Cronin, C. Cook, Possible stimuli for strength and power adaptation: acute hormonal responses. Sports Med. 36, 215–238 (2006)PubMedCrossRef

13.

F. Derbré, S. Vincent, B. Maitel, C. Jacob, P. Delamarche, A. Delamarche, H. Zouhal, Androgen responses to sprint exercise in young men. Int. J. Sports Med. 31, 291–297 (2010)PubMedCrossRef

14.

M.S. Tremblay, J.L. Copeland, W. Van Helder, Influence of exercise duration on post-exercise steroid hormone responses in trained males. Eur. J. Appl. Physiol. 94, 505–513 (2005)PubMedCrossRef

15.

W.J. Kraemer, N.A. Ratamess, Hormonal responses and adaptations to resistance exercise and training. Sports Med. 35, 339–361 (2005)PubMedCrossRef

16.

J.L. Vingren, W.J. Kraemer, N.A. Ratamess, J.M. Anderson, J.S. Volek, C.M. Maresh, Testosterone physiology in resistance exercise and training: the up-stream regulatory elements. Sports Med. 40, 1037–1053 (2010)PubMedCrossRef

17.

V.D. Sherk, K.A. Sherk, S. Kim, K.C. Young, D.A. Bemben, Hormone responses to a continuous bout of rock climbing in men. Eur. J. Appl. Physiol. 111, 687–693 (2011)PubMedCrossRef

18.

K. Kuoppasalmi, Plasma testosterone and sex-hormone-binding globulin capacity in physical exercise. Scand. J. Clin. Lab. Invest. 40, 411–418 (1980)PubMedCrossRef

19.

J.E. Wilkerson, S.M. Horvath, B. Gutin, Plasma testosterone during treadmill exercise. J. Appl. Physiol. 49, 249–253 (1980)PubMed

20.

D.C. Cumming, L.A. Brunsting, G. Strich, A.L. Ries, R.W. Rebar, Reproductive hormone increases in response to acute exercise in men. Med. Sci. Sports Exerc. 18, 369–373 (1986)PubMed

21.

A. Dessypris, K. Kuoppasalmi, H. Adlercreutz, Plasma cortisol, testosterone, androstenedione and luteinizing hormone (LH) in a non-competitive marathon run. J. Steroid Biochem. 7, 33–37 (1976)PubMedCrossRef

22.

A.N. Elias, A.F. Wilson, Exercise and gonadal function. Hum. Reprod. 8, 1747–1761 (1993)PubMed

23.

K. Kuoppasalmi, H. Naveri, S. Rehunen, M. Harkonen, H. Adlercreutz, Effect of strenuous anaerobic running exercise on plasma growth hormone, cortisol, luteinizing hormone, testosterone, androstenedione, estrone and estradiol. J. Steroid Biochem. 7, 823–829 (1976)PubMedCrossRef

24.

L. Di Luigi, L. Guidetti, C. Baldari, A. Fabbri, C. Moretti, F. Romanelli, Physical stress and qualitative gonadotropin secretion: LH biological activity at rest and after exercise in trained and untrained men. Int. J. Sports Med. 23, 307–312 (2002)PubMedCrossRef

25.

M. Grandys, J. Majerczak, K. Duda, J. Zapart-Bukowska, J. Kulpa, J.A. Zoladz, Endurance training of moderate intensity increases testosterone concentration in young, healthy men. Int. J. Sports Med. 30, 489–495 (2009)PubMedCrossRef

26.

J.P. Ahtiainen, J.J. Hulmi, W.J. Kraemer, M. Lehti, K. Nyman, H. Selänne, M. Alen, A. Pakarinen, J. Komulainen, V. Kovanen, A.A. Mero, K. Häkkinen, Heavy resistance exercise training and skeletal muscle androgen receptor expression in younger and older men. Steroids 76, 183–192 (2011)PubMedCrossRef

27.

A.C. Hackney, Effects of endurance exercise on the reproductive system of men: the “exercise-hypogonadal male condition”. J. Endocrinol. Invest. 31, 932–938 (2008)PubMed

28.

M.R. Safarinejad, K. Azma, A.A. Kolahi, The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus-pituitary-testis axis, and semen quality: a randomized controlled study. J. Endocrinol. 200, 259–271 (2009)PubMedCrossRef

29.

M. Duclos, Effects of physical training on endocrine functions. Ann. Endocrinol. 62, 19–32 (2001)

30.

M. Maynar, R. Timon, A. González, G. Olcina, F. Toribio, J.I. Maynar, M.J. Caballero, SHBG, plasma, and urinary androgens in weight lifters after a strength training. J. Physiol. Biochem. 66, 137–142 (2010)PubMedCrossRef

31.

B.C. Nindl, W.J. Kraemer, D.R. Deaver, J.L. Peters, J.O. Marx, J.T. Heckman, J.A. Lumis, LH secretion and testosterone concentrations are blunted after resistance exercise in men. J. Appl. Physiol. 91, 1251–1258 (2001)PubMed

32.

G.D. Wheeler, S.R. Wall, A.N. Belcastro, D.C. Cumming, Reduced serum testosterone and prolactin levels in male distance runners. JAMA 252, 514–516 (1982)CrossRef

33.

J.C. Arce, M.J. De Souza, L.S. Pescatelo, A.A. Luciano, Subclinical alterations in hormone and semen profile in athletes. Fertil. Steril. 59, 398–404 (1993)PubMed

34.

M.J. De Souza, J.C. Arce, L.S. Pescatello, H.S. Scherzer, A.A. Luciano, Gonadal hormones and semen quality in male runners. A volume threshold effect of endurance training. Int. J. Sports Med. 15, 383–391 (1994)PubMedCrossRef

35.

A. Lucia, J.L. Chicharro, M. Perez, L. Serratosa, F. Bandres, J.C. Legido, Reproductive function in male endurance athletes: sperm analysis and hormonal profile. J. Appl. Physiol. 81, 2627–2636 (1996)PubMed

36.

A.C. Roberts, R.D. McClure, R.I. Weiner, G.A. Brooks, Overtraining affects male reproductive status. Fertil. Steril. 60, 686–692 (1993)PubMed

37.

J.W. Ayers, Y. Komesu, T. Romani, R. Ansbacher, Anthropomorphic, hormonal, and psychologic correlates of semen quality in endurance-trained male athletes. Fertil. Steril. 43, 917–921 (1985)PubMed

38.

C.J. Bagatell, W.J. Bremner, Sperm counts and reproductive hormones in male marathoners and lean controls. Fertil. Steril. 53, 688–692 (1990)PubMed

39.

M.J. De Souza, B.E. Miller, The effect of endurance training on reproductive function in male runners. A ‘volume threshold’ hypothesis. Sports Med. 23, 357–374 (1997)PubMedCrossRef

40.

D. Vaamonde, M.E. Da Silva-Grigoletto, J.M. García-Manso, R. Vaamonde-Lemos, R.J. Swanson, S.C. Oehninger, Response of semen parameters to three training modalities. Fertil. Steril. 92, 1941–1946 (2009)PubMedCrossRef

41.

L.A. Wise, D.W. Cramer, M.D. Hornstein, R.K. Ashby, S.A. Missmer, Physical activity and semen quality among men attending an infertility clinic. Fertil. Steril. 95, 1025–1030 (2011)PubMedCrossRef

42.

F. Pelliccione, V. Verratti, A. D’Angeli, A. Micillo, C. Doria, A. Pezzella, G. Iacutone, F. Francavilla, C. Di Giulio, S. Francavilla, Physical exercise at high altitude is associated with a testicular dysfunction leading to reduced sperm concentration but healthy sperm quality. Fertil. Steril. 96, 28–33 (2011)PubMedCrossRef

43.

B. Koch, S. Glaser, C. Schaper, A. Krebs, M. Nauck, M. Dorr, R. Haring, H. Volzke, S.B. Felix, R. Ewert, H. Wallaschofski, N. Friedrich, Association between serum testosterone and sex hormone-binding globulin and exercise capacity in men: results of the Study of Health in Pomerania (SHIP). J. Androl. 32, 135–143 (2011)PubMedCrossRef

44.

E. Darby, B.D. Anawalt, Male hypogonadism: an update on diagnosis and treatment. Treat. Endocrinol. 4, 293–309 (2005)PubMedCrossRef

45.

E. Orwoll, L.C. Lambert, L.M. Marshall, J. Blank, E. Barrett-Connor, J. Cauley, K. Ensrud, S.R. Cummings, Osteoporotic Fractures in Men Study Group. Endogenous testosterone levels, physical performance, and fall risk in older men. Arch. Intern. Med. 166, 2124–2131 (2006)PubMedCrossRef

46.

A.D. Seftel, Male hypogonadism. Part I: epidemiology of hypogonadism. Int. J. Impot. Res. 18, 115–120 (2006)PubMedCrossRef

47.

L. Di Luigi, P. Sgrò, V. Fierro, S. Bianchini, G. Battistini, V. Magini, E.A. Jannini, A. Lenzi, Prevalence of undiagnosed testosterone deficiency in aging athletes: does exercise training influence the symptoms of male hypogonadism? J. Sex. Med. 7, 2591–2601 (2010)PubMed

48.

L. Di Luigi, P. Sgrò, F. Romanelli, M. Mazzarino, F. Donati, M.C. Braganò, S. Bianchini, V. Fierro, M. Casasco, F. Botrè, A. Lenzi, Urinary and serum hormones profiles after testosterone enanthate administration in male hypogonadism: concerns on the detection of doping with testosterone in treated hypogonadal athletes. J. Endocrinol. Invest. 32, 445–453 (2009)PubMed

49.

L. Di Luigi, P. Sgrò, A. Aversa, S. Migliaccio, S. Bianchini, F. Botrè, F. Romanelli, A. Lenzi, Concerns about serum androgens monitoring during testosterone replacement treatments in hypogonadal male athletes: a pilot study. J. Sex. Med. 9, 873–886 (2012)

50.

L.J. Gooren, H.M. Behre, Testosterone treatment of hypogonadal men participating in competitive sport. Andrologia 40, 195–199 (2008)PubMedCrossRef

51.

J.Y.W. Cheng, E.M.L. Ng, Body mass index, physical activity and erectile dysfunction: an U-shaped relationship from population-based study. Int. J. Obesity 31, 1571–1578 (2007)CrossRef

52.

K. Esposito, F. Giugliano, C. Di Palo, G. Giugliano, R. Marfella, F. D’Andrea, M. D’Armiento, D. Giugliano, Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA 291, 2978–2984 (2004)PubMedCrossRef

53.

C. Gazzaruso, S.B. Solerte, A. Pujia, A. Coppola, M. Vezzoli, F. Salvucci, C. Valenti, A. Giustina, A. Garzaniti, Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phosphodiesterase inhibitors. J. Am. Coll. Cardiol. 51, 2040–2044 (2008)PubMedCrossRef

54.

C. Gazzaruso, A. Coppola, T. Montalcini, C. Valenti, A. Garzaniti, G. Pelissero, F. Salvucci, P. Gallotti, A. Pujia, C. Falcone, S.B. Solerte, A. Giustina, Erectile dysfunction can improve the effectiveness of the current guidelines for the screening for asymptomatic coronary artery disease in diabetes. Endocrine 40, 273–279 (2011)PubMedCrossRef

55.

J.L. Hannan, M.T. Maio, M. Komolova, M.A. Adams, Beneficial impact of exercise and obesity interventions on erectile function and its risk factors. J. Sex. Med. 6(Suppl. 3), 254–261 (2009)PubMedCrossRef

56.

K. Horasanli, U. Boylu, M. Kendirci, C. Miroglu, Do lifestyle changes work for improving erectile dysfunction? Asian J. Androl. 10, 28–35 (2008)PubMedCrossRef

57.

C.W. Kratzik, J.E. Lackner, I. Märk, E. Rücklinger, J. Schmidbauer, G. Lunglmayr, G. Schatzl, How much physical activity is needed to maintain erectile function? Results of the Androx Vienna Municipality Study. Eur. Urol. 55, 509–516 (2009)PubMedCrossRef

58.

S. La Vignera, R. Condorelli, E. Vicari, R. D’Agata, A. Calogero, Aerobic physical activity improves endothelial function in the middle-aged patients with erectile dysfunction. Aging Male 14, 265–272 (2011)PubMedCrossRef

59.

D.R. Meldrum, J.C. Gambone, M.A. Morris, K. Esposito, D. Giugliano, L.J. Ignaro, Lifestyle and metabolic approaches to maximizing erectile and vascular health. Int. J. Impot. Res. 24, 61–68 (2012)

60.

T.G. Travison, A.B. Araujo, V. Kupelian, A.B. O’Donnell, J.B. McKinlay, The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. J. Clin. Endocrinol. Metab. 92, 549–555 (2007)PubMedCrossRef

61.

S.T. Skarda, M.R. Burge, Prospective evaluation of risk factors for exercise-induced hypogonadism in male runners. West. J. Med. 169, 9–12 (1998)PubMed

62.

N.J. Dettori, D.C. Norvell, Non-traumatic bicycle injuries: a review of the literature. Sports Med. 36, 7–18 (2006)PubMedCrossRef

63.

I. Goldstein, A.L. Lurie, J.P. Lubisich, Bicycle riding, perineal trauma, and erectile dysfunction: data and solutions. Curr. Urol. Rep. 8, 491–497 (2007)PubMedCrossRef

64.

V. Huang, R. Munarriz, I. Goldstein, Bicycle riding and erectile dysfunction: an increase in interest (and concern). J. Sex. Med. 2, 596–604 (2005)PubMedCrossRef

65.

L. Di Luigi, A. Casini, F. Romanelli, F. Pigozzi, A. Parisi, I.G. Ricagni, F. Leonelli, G. Fortunio, A. Isidori, Role of sport medicine in andrological prevention. Med. Sport 47, 665–670 (1994)

66.

E. Rigano, G. Santoro, P. Impellizzeri, P. Antonuccio, D. Fugazzotto, L. Bitto, C. Romeo, Varicocele and sport in the adolescent age. Preliminary report on the effects of physical training. J. Endocrinol. Invest. 27, 130–132 (2004)PubMed

67.

A. Scaramuzza, R. Tavana, A. Marchi, Varicocele in young soccer players. Lancet 348, 1180–1181 (1996)PubMedCrossRef

68.

L. Di Luigi, V. Gentile, F. Pigozzi, A. Parisi, D. Giannetti, F. Romanelli, Physical activity as a possible aggravating factor for athletes with varicocele: impact on the semen profile. Hum. Reprod. 16, 1180–1184 (2001)PubMedCrossRef

69.

N. Zampieri, A. Dall’Agnola, Subclinical varicocele and sports: a longitudinal study. Urology 77, 1199–1202 (2011)PubMedCrossRef

70.

L. Di Luigi, F. Romanelli, A. Casini, V. Gentile, A. Parisi, F. Leonelli, I.G. Ricagni, F. Pigozzi, Varicocele and sport: clinical management and sport eligibility in athletes. Med. Sport 48, 313–327 (1995)

71.

S. Basaria, Androgen abuse in athletes: detection and consequences. J. Clin. Endocrinol. Metab. 95, 1533–1543 (2010)PubMedCrossRef

72.

F. Hartgens, H. Kuipers, Effects of androgenic-anabolic steroids in athletes. Sports Med. 34, 513–554 (2004)PubMedCrossRef

73.

L. Di Luigi, F. Romanelli, A. Lenzi, Androgenic-anabolic steroids abuse in males. J. Endocrinol. Invest. 28(3 suppl), 81–84 (2005)PubMed

74.

D.J. Handelsman, Androgen misuse and abuse. Best Pract. Res. Clin. Endocrinol. Metab. 25, 377–389 (2011)PubMedCrossRef

75.

I. Pirola, C. Cappelli, A. Delbarba, T. Scalvini, B. Agosti, D. Assanelli, A. Sonetti, M. Castellano, Anabolic steroids purchased on the internet as a cause of prolonged hypogonadotropic hypogonadism. Fertil. Steril. 94, 2331.e1–2331.e3 (2010)CrossRef

76.

P. Laure, C. Binsinger, Doping prevalence among preadolescent athletes: a 4-year follow-up. Br. J. Sports Med. 41, 660–663 (2007)PubMedCrossRef

77.

T.M. Smurawa, J.A. Congeni, Testosterone precursors: use and abuse in pediatric athletes. Pediatr. Clin. North Am. 54, 787–796 (2007)PubMedCrossRef

78.

P. Van den Berg, D. Neumark-Sztainer, G. Cafri, M. Wall, Steroid use among adolescents: longitudinal findings from Project EAT. Pediatrics 119, 476–486 (2007)CrossRef

79.

G.L. De Souza, J. Hallak, Anabolic steroids and male infertility: a comprehensive review. B.J.U. Int. 108, 1860–1865 (2011)CrossRef

80.

T. Schürmeyer, U.A. Knuth, L. Belkien, E. Nieschlag, Reversible azoospermia induced by the anabolic steroid 19-nortestosterone. Lancet 8374, 417–420 (1984)CrossRef

81.

J. Torres-Calleja, M. González-Unzaga, R. DeCelis-Carrillo, L. Calzada-Sánchez, N. Pedrón, Effect of androgenic anabolic steroids on sperm quality and serum hormone levels in adult male bodybuilders. Life Sci. 68, 1769–1774 (2001)PubMedCrossRef

82.

H. Martikainen, M. Alén, P. Rahkila, R. Vihko, Testicular responsiveness to human chorionic gonadotrophin during transient hypogonadotrophic hypogonadism induced by androgenic/anabolic steroids in power athletes. J. Steroid Biochem. 25, 109–112 (1986)PubMedCrossRef

83.

A. Drakeley, R. Gazvani, I. Lewis-Jones, Duration of azoospermia following anabolic steroids. Fertil. Steril. 81, 226 (2004)PubMedCrossRef

84.

J.P. Jarow, L.I. Lipshultz, Anabolic steroid-induced hypogonadotropic hypogonadism. Am. J. Sports Med. 18, 429–431 (1990)PubMedCrossRef

85.

P.J. Turek, R.H. Williams, J.H. Gilbaugh 3rd, L.I. Lipshultz, The reversibility of anabolic steroid-induced azoospermia. J. Urol. 153, 1628–1630 (1995)PubMedCrossRef

86.

R. Tan, D. Vasudevan, Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse. Fertil. Steril. 79, 203–205 (2003)PubMedCrossRef

87.

D.K. Menon, Successful treatment of anabolic steroid-induced azoospermia with human chorionic gonadotropin and human menopausal gonadotropin. Fertil. Steril. 79 (Suppl 3), 1659–1661 (2003)

88.

E.A. Bocchi, G. Guimaraes, A. Mocelin, F. Bacal, G. Bellotti, J.F. Ramires, Sildenafil effects on exercise, neurohormonal activation, and erectile dysfunction in congestive heart failure: a double-blind, placebo-controlled, randomized study followed by a prospective treatment for erectile dysfunction. Circulation 106, 1097–1103 (2002)PubMedCrossRef

89.

H.A. Ghofrani, R. Voswinckel, F. Reichenberger, H. Olschewski, P. Haredza, B. Karadas, R.T. Schermuly, N. Weissmann, W. Seeger, F. Grimminger, Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study. J. Am. Coll. Cardiol. 44, 1488–1496 (2004)PubMed

90.

H.A. Ghofrani, F. Reichenberger, M.G. Kohstall, E.H. Mrosek, T. Seeger, H. Olschewski, W. Seeger, F. Grimminger, Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann. Intern. Med. 141, 169–177 (2004)PubMed

91.

A.R. Hsu, K.E. Barnholt, N.K. Grundmann, J.H. Lin, S.W. McCallum, A.L. Friedlander, Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia. J. Appl. Physiol. 100, 2031–2040 (2006)PubMedCrossRef

92.

J.P. Richalet, P. Gratadour, P. Robach, I. Pham, M. Dechaux, A. Joncquiert-Latarjet, P. Mollard, J. Brugniaux, J. Cornolo, Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am. J. Respir. Crit. Care Med. 171, 275–281 (2005)PubMedCrossRef

93.

R.A. Kloner, M. Mitchell, J.T. Emmick, Cardiovascular effects of tadalafil. Am. J. Cardiol. 92, 37M–46M (2003)PubMedCrossRef

94.

L. Di Luigi, C. Baldari, P. Sgrò, G.P. Emerenziani, M.C. Gallotta, S. Bianchini, F. Romanelli, F. Pigozzi, A. Lenzi, L. Guidetti, The type 5 phosphodiesterase inhibitor tadalafil influences salivary cortisol, testosterone, and dehydroepiandrosterone sulphate responses to maximal exercise in healthy man. J. Clin. Endocrinol. Metab. 93, 3510–3514 (2008)PubMedCrossRef

95.

L. Guidetti, G.P. Emerenziani, M.C. Gallotta, F. Pigozzi, L. Di Luigi, C. Baldari, Effect of tadalafil on anaerobic performance indices in healthy athletes. Br. J. Sports Med. 42, 130–133 (2008)PubMedCrossRef

96.

L. Di Luigi, P. Sgrò, C. Baldari, M.C. Gallotta, G.P. Emerenziani, C. Crescioli, S. Bianchini, F. Romanelli, A. Lenzi, L. Guidetti, The phosphodiesterases type 5 inhibitor tadalafil reduces the activation of the hypothalamus-pituitary-adrenal axis in men during cycle ergometric exercise. Am. J. Physiol. Endocrinol. Metab. (2012). doi:10.1152/ajpendo.00573.2011

97.

S. Sabatini, P. Sgrò, G. Duranti, R. Ceci, L. Di Luigi, Tadalafil alters energy metabolism in C2C12 skeletal muscle cells. Acta Biochim. Pol. 58, 237–241 (2011)PubMed

98.

D.E. Greydanus, D.R. Patel, E.F. Luckstead, H.D. Pratt, Value of sports pre-participation examination in health care for adolescents. Med. Sci. Monit. 10, RA204–RA214 (2004)PubMed

99.

L. Di Luigi, A. Pelliccia, A. Bonetti, G. Francavilla, G.P. Ganzit, A. Veicsteinas, D. Accettura, B. Bagnini, R. Cantore, W. Castagna, C. Ciacciarelli, G. Costini, B. Cuffari, E. Drago, V. Federici, C.G. Gribaudo, G. Iacovelli, L. Landolfi, G. Menichetti, U. Olla Atzeni, A. Parisi, A. Pizzi, M. Rosa, F. Santelli, F. Santilio, F. Culasso, Clinical efficacy and preventive role of the pre-partecipation physical examination in Italy: results of a national study on 32,652 athletes examined at the operative units of sports medicine associated with the Italian Federation of Sport Medicine (FMSI). Med. Sport 57, 243–270 (2004)

100.

F. Minuto, A. Barreca, G. Melioli, Indirect evidences of hormone abuse. Proof of doping? J. Endocrinol. Invest. 26, 919–923 (2003)PubMed

Titel: Andrological aspects of physical exercise and sport medicine
verfasst von: Luigi Di Luigi
Francesco Romanelli
Paolo Sgrò
Andrea Lenzi
Publikationsdatum: 01.10.2012
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 2/2012
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-012-9655-6

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Andrological aspects of physical exercise and sport medicine

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Update Innere Medizin

Springer Medizin

Abstract

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