Erschienen in:
28.10.2016 | Editorial
Fish scale is a suitable model for analyzing determinants of skeletal fragility in type 2 diabetes
verfasst von:
Nobuo Suzuki, Kei-ichiro Kitamura, Atsuhiko Hattori
Erschienen in:
Endocrine
|
Ausgabe 3/2016
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Excerpt
The teleost fish has a unique hard tissue, scales that consist of osteoblasts (bone formation cells), osteoclasts (bone resorption cells), and calcified bone matrix, including type 1 collagen, bone
γ-carboxyglutamic acid protein, osteonectin, and hydroxyapatite [
1‐
6]. In all vertebrates, including teleosts, blood calcium levels are strictly kept at a constant concentration (2 ~ 3 mM) between each species [
7]. Teleost scales have an important function in regulating blood calcium levels because teleost scales, having both osteoblasts and osteoclasts, known to function as potential internal calcium reservoirs similar to those in the endoskeletons of mammals [
2,
5,
8]. Particularly, in fresh water teleosts such as zebrafish and goldfish, which live in a low-calcium environment, their scales play a very important role in regulating the plasma calcium level. …
