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Endocrine

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26.04.2019 | Original Article

Bone turnover is altered during 72 h of sleep restriction: a controlled laboratory study

verfasst von: Jeffery S. Staab, Tracey J. Smith, Marques Wilson, Scott J. Montain, Erin Gaffney-Stomberg

Erschienen in: Endocrine | Ausgabe 1/2019

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Abstract

Purpose

The objective of the study was to evaluate how controlled, short-term sleep restriction (SR; 72 h) alters markers of bone formation and resorption and urinary calcium (Ca) output.

Methods

Ten healthy, sleep-adequate, male soldiers were housed in the research facility one day prior to and for the duration of SR. Diet was controlled to provide adequate energy balance and macronutrient distribution, meeting the recommended dietary allowance (RDA) for Ca. Subjects engaged in light activities to maintain wakefulness and were allowed 2 h of sleep per night (0430–0630 hours). Blood samples were collected each morning at 0 h (baseline) and 24, 48, and 72 h of SR. Serum was assayed for parathyroid hormone (PTH), bone alkaline phosphatase (BAP), tartrate-resistant acid phosphatase (TRAP), and C-terminal telopeptide of type I collagen (CTX). Urine was collected in 24 h increments during SR for measurement of Ca and creatinine (Cr).

Results

BAP was reduced at 24 h (P= 0.015) and resorption markers TRAP and CTX were increased after 48 and 72 h of SR compared to baseline (P < 0.05). The ratio of BAP:TRAP was significantly lower (P= 0.017) at 48 and 72 h of SR. In contrast, total 24 h urinary Ca and Ca/Cr excretion were unchanged.

Conclusions

Markers of bone formation and resorption are uncoupled in response to as little as 48 h of SR even when Ca intake is at the RDA. Sleep deprivation may be a risk factor for reduced bone health due to perturbations in bone turnover.

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Titel: Bone turnover is altered during 72 h of sleep restriction: a controlled laboratory study
verfasst von: Jeffery S. Staab
Tracey J. Smith
Marques Wilson
Scott J. Montain
Erin Gaffney-Stomberg
Publikationsdatum: 26.04.2019
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 1/2019
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-019-01937-6

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