Skip to main content
Erschienen in: Neurocritical Care 3/2010

01.12.2010 | Original Article

Hemicraniectomy for Malignant Middle Cerebral Artery Infarction: Retrospective Consent to Decompressive Surgery Depends on Functional Long-Term Outcome

verfasst von: Ines C. Kiphuth, Martin Köhrmann, Christoph Lichy, Stefan Schwab, Hagen B. Huttner

Erschienen in: Neurocritical Care | Ausgabe 3/2010

Einloggen, um Zugang zu erhalten

Abstract

Background

Decompressive surgery for malignant middle cerebral artery infarction increases the number of surviving patients; this, however, leaves some patients severely disabled. This study analyzed the patients’ retrospective consent to hemicraniectomy in light of the experienced functional outcome 12 months after hospital stay.

Methods

This retrospective study included all patients who underwent decompressive hemicraniectomy for malignant middle cerebral artery infarction in the Department of Neurology, University of Erlangen, Germany, from January 2006 until March 2009. Data on mortality and functional outcome (measured by the modified Rankin Scale; mRS) 6 and 12 months after treatment were correlated with retrospective consent to hemicraniectomy as well as with a quality of life instrument (EuroQol). Data were obtained by structured telephone interviews with the patients themselves or their closest relatives.

Results

In the study period 28 patients received decompressive surgery. Retrospective consent to hemicraniectomy was 82.1%. Five patients, or their closest relatives, would not agree to hemicraniectomy again, given their functional outcome after 1 year. Two out of two patients who experienced an mRS of 5 would not have consented. Low quality of life was most often declared in this subgroup.

Conclusions

Retrospective consent to hemicraniectomy for treatment of malignant MCA infarction depends on functional long-term outcome. We need to identify those patients who would survive the malignant MCA infarction due to decompressive surgery but only reach a severely reduced functional status.
Literatur
1.
Zurück zum Zitat Hacke W, Schwab S, Horn M, Spranger M, De Georgia M, von Kummer R. ‘Malignant’ middle cerebral artery territory infarction: clinical course and prognostic signs. Arch Neurol. 1996;53:309–15.PubMed Hacke W, Schwab S, Horn M, Spranger M, De Georgia M, von Kummer R. ‘Malignant’ middle cerebral artery territory infarction: clinical course and prognostic signs. Arch Neurol. 1996;53:309–15.PubMed
2.
Zurück zum Zitat Frank JI. Large hemispheric infarction, deterioration, and intracranial pressure. Neurology. 1995;45:1286–90.PubMed Frank JI. Large hemispheric infarction, deterioration, and intracranial pressure. Neurology. 1995;45:1286–90.PubMed
3.
Zurück zum Zitat Ropper AH, Shafran B. Brain edema after stroke. Clinical syndrome and intracranial pressure. Arch Neurol. 1984;41:26–9.PubMed Ropper AH, Shafran B. Brain edema after stroke. Clinical syndrome and intracranial pressure. Arch Neurol. 1984;41:26–9.PubMed
4.
Zurück zum Zitat Schwab S, Steiner T, Aschoff A, Schwarz S, Steiner HH, Jansen O, Hacke W. Early hemicraniectomy in patients with complete middle cerebral artery infarction. Stroke. 1998;29:1888–93.PubMed Schwab S, Steiner T, Aschoff A, Schwarz S, Steiner HH, Jansen O, Hacke W. Early hemicraniectomy in patients with complete middle cerebral artery infarction. Stroke. 1998;29:1888–93.PubMed
5.
Zurück zum Zitat Vahedi K, Vicaut E, Mateo J, Kurtz A, Orabi M, Guichard JP, Boutron C, Couvreur G, Rouanet F, Touzé E, Guillon B, Carpentier A, Yelnik A, George B, Payen D, Bousser MG, DECIMAL Investigators. Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL trial). Stroke. 2007;38:2506–17.CrossRefPubMed Vahedi K, Vicaut E, Mateo J, Kurtz A, Orabi M, Guichard JP, Boutron C, Couvreur G, Rouanet F, Touzé E, Guillon B, Carpentier A, Yelnik A, George B, Payen D, Bousser MG, DECIMAL Investigators. Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL trial). Stroke. 2007;38:2506–17.CrossRefPubMed
6.
Zurück zum Zitat Jüttler E, Schwab S, Schmiedek P, Unterberg A, Hennerici M, Woitzik J, Witte S, Jenetzky E, Hacke W, DESTINY Study Group. Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial. Stroke. 2007;38:2518–25.CrossRefPubMed Jüttler E, Schwab S, Schmiedek P, Unterberg A, Hennerici M, Woitzik J, Witte S, Jenetzky E, Hacke W, DESTINY Study Group. Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial. Stroke. 2007;38:2518–25.CrossRefPubMed
7.
Zurück zum Zitat Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB, HAMLET investigators. Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery Infarction with Life-Threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial. Lancet Neurol. 2009;8:326–33.CrossRefPubMed Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB, HAMLET investigators. Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery Infarction with Life-Threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial. Lancet Neurol. 2009;8:326–33.CrossRefPubMed
8.
Zurück zum Zitat Vahedi K, Hofmeijer J, Juettler E, Vicaut E, George B, Algra A, Amelink GJ, Schmiedeck P, Schwab S, Rothwell PM, Bousser MG, van der Worp HB, Hacke W, for the DECIMAL, DESTINY and HAMLET investigators. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol. 2007;6:215–22. Vahedi K, Hofmeijer J, Juettler E, Vicaut E, George B, Algra A, Amelink GJ, Schmiedeck P, Schwab S, Rothwell PM, Bousser MG, van der Worp HB, Hacke W, for the DECIMAL, DESTINY and HAMLET investigators. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol. 2007;6:215–22.
9.
Zurück zum Zitat Huttner HB, Schwab S. Malignant middle cerebral artery infarction: clinical characteristics, treatment strategies, and future perspectives. Lancet Neurol. 2009;8:949–58.CrossRefPubMed Huttner HB, Schwab S. Malignant middle cerebral artery infarction: clinical characteristics, treatment strategies, and future perspectives. Lancet Neurol. 2009;8:949–58.CrossRefPubMed
10.
Zurück zum Zitat Mitchell P, Gregson BA, Crossman J, Gerber C, Jenkins A, Nicholson C, Todd NV, Ross N, Bhattathiri P, Nissen J, Crawford PJ, Wynne-Jones G, Sengupta RP, Graham L, Gani A, Davis M, Gray C, Barer D, Dorman P, Millar D, Williamson J, Durham H, Jones A, Hastie H, Mendelow AD. Reassessment of the HAMLET study. Lancet Neurol. 2009;8:602–3.CrossRefPubMed Mitchell P, Gregson BA, Crossman J, Gerber C, Jenkins A, Nicholson C, Todd NV, Ross N, Bhattathiri P, Nissen J, Crawford PJ, Wynne-Jones G, Sengupta RP, Graham L, Gani A, Davis M, Gray C, Barer D, Dorman P, Millar D, Williamson J, Durham H, Jones A, Hastie H, Mendelow AD. Reassessment of the HAMLET study. Lancet Neurol. 2009;8:602–3.CrossRefPubMed
11.
Zurück zum Zitat Van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJA, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988;19:604–7.PubMed Van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJA, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988;19:604–7.PubMed
12.
Zurück zum Zitat Dorman PJ, Waddell F, Slattery J, Dennis M, Sandercock P. Is the EuroQol a valid measure of health-related quality of life after stroke? Stroke. 1997;28:1876–82.PubMed Dorman PJ, Waddell F, Slattery J, Dennis M, Sandercock P. Is the EuroQol a valid measure of health-related quality of life after stroke? Stroke. 1997;28:1876–82.PubMed
13.
Zurück zum Zitat EuroQol. A new facility for the measurement of health-related quality of life. The EuroQol Group. Health Policy. 1990;16:199–208. EuroQol. A new facility for the measurement of health-related quality of life. The EuroQol Group. Health Policy. 1990;16:199–208.
14.
Zurück zum Zitat Angus DC, Carlet J. Surviving intensive care: a report from the 2002 brussels roundtable. Intensive Care Med. 2003;29:368–77.PubMed Angus DC, Carlet J. Surviving intensive care: a report from the 2002 brussels roundtable. Intensive Care Med. 2003;29:368–77.PubMed
15.
Zurück zum Zitat Foerch C, Lang JM, Krause J, Raabe A, Sitzer M, Seifert V, Steinmetz H, Kessler KR. Functional impairment, disability, and quality of life outcome after decompressive hemicraniectomy in malignant middle cerebral artery infarction. J Neurosurg. 2004;101:248–54.CrossRefPubMed Foerch C, Lang JM, Krause J, Raabe A, Sitzer M, Seifert V, Steinmetz H, Kessler KR. Functional impairment, disability, and quality of life outcome after decompressive hemicraniectomy in malignant middle cerebral artery infarction. J Neurosurg. 2004;101:248–54.CrossRefPubMed
16.
Zurück zum Zitat Benejam B, Sahuquillo J, Poca MA, Frascheri L, Solana E, Delgado P, Junqué C. Quality of life and neurobehavioral changes in survivors of malignant middle cerebral artery infarction. J Neurol. 2009;256:1126–33.CrossRefPubMed Benejam B, Sahuquillo J, Poca MA, Frascheri L, Solana E, Delgado P, Junqué C. Quality of life and neurobehavioral changes in survivors of malignant middle cerebral artery infarction. J Neurol. 2009;256:1126–33.CrossRefPubMed
Metadaten
Titel
Hemicraniectomy for Malignant Middle Cerebral Artery Infarction: Retrospective Consent to Decompressive Surgery Depends on Functional Long-Term Outcome
verfasst von
Ines C. Kiphuth
Martin Köhrmann
Christoph Lichy
Stefan Schwab
Hagen B. Huttner
Publikationsdatum
01.12.2010
Verlag
Humana Press Inc
Erschienen in
Neurocritical Care / Ausgabe 3/2010
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-010-9449-8

Weitere Artikel der Ausgabe 3/2010

Neurocritical Care 3/2010 Zur Ausgabe

Practical Pearl

A PRESsing Dissection

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.