nach oben

Medical Oncology

Erschienen in:

01.03.2013 | Original Paper

Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern

verfasst von: Fatemeh Yazarloo, Reza Shirkoohi, Maryam Beigom Mobasheri, Amirhossein Emami, Mohammad Hossein Modarressi

Erschienen in: Medical Oncology | Ausgabe 1/2013

Einloggen, um Zugang zu erhalten

Abstract

Cancer testis antigens (CTAs) have normal expression restricted in the testis and also inappropriate expression in various tumor types. Special and favorable characteristics of these genes, as being immunogenic and therefore having the potential to be used as tumor vaccine, have made them as one of the star attractions of the cancer research. Acute myeloid leukemia (AML) is a highly heterogeneous hematological disorder with various reported changes in gene expression. To find new CTA genes in AML, we analyzed the expression pattern of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L using real-time quantitative PCR in 51 AMLs and 6 myelodysplastic syndrome cases in comparison with 33 healthy controls. The expression of the studied genes, noticeably OIP5 and TAF7L, differed between studied groups in a gender-dependent manner. Upregulation of OIP5 was observed only in ~41 % of the female AML patients as compared to the healthy females. The remaining ~59 % of the male AML patients, when compared to the healthy males, displayed downregulation of TAF7L. This finding may affect many aspects of AML such as diagnosis, prognosis assessment and treatment choice.

Ley TJ, Mardis ER, Ding L, et al. DNA sequencing of a cytogenetically normal acute myeloid leukemia genome. Nature. 2008;456(7218):66–72.PubMedCrossRef

Lowenberg B. Acute myeloid leukemia: the challenge of capturing disease variety. Hematol Am Soc Hematol Educ Program. 2008;19074046:1–11.CrossRef

Dohner H. Implication of the molecular characterization of acute myeloid leukemia. Hematol Am Soc Hematol Educ Program. 2007;18024659:412–9.CrossRef

Bacher U, Kohlman A, Haferlach C. Gene expression analysis in acute myeloid leukemia. Mag Eur Medical Oncol. 2008;1:235–41.CrossRef

Mobasheri MB, Modarressi MH, Shabani M, Asgarian H, Sharifian RA, Vossough P, Shokri F. Expression of the testis-specific gene, TSGA10, in Iranian patients with acute lymphoblastic leukemia (ALL). Leuk Res. 2006;30(7):883–9 (Epub 2006 Jan 6).

Ghafouri-Fard S, Modarressi M-H. Cancer-testis antigens: potential targets for cancer immunotherapy. Arch Iran Med. 2009;12(19566358):395–404.PubMed

Simpson AJG, Caballero OL, Jungbluth A, Chen Y-T, Old LJ. Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer. 2005;5(16034368):615–25.PubMedCrossRef

Ji H, Ehrlich LIR, et al. A comprehensive methylome map of lineage commitment from hematopoietic progenitors. Nature. 2010;467(7313):338–42.PubMedCrossRef

Ghafouri-Fard S, Abbasi A, Moslehi H, Faramarzi N, Taba Taba Vakili S, Mobasheri MB, Modarressi MH. Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features. Br J Dermatol. 2010;162(4):772–9 (Epub 2009 Nov 3).

10.

Mobasheri MB, Jahanzad I, Mohagheghi MA, Aarabi M, Farzan S, Modarressi MH. Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features. Cancer Detect Prev. 2007;31(4):296–302.PubMedCrossRef

11.

Katayama H, Sen S. Aurora kinase inhibitors as anticancer molecules. Biochim Biophys Acta. 2010;1799(20863917):829–39.PubMed

12.

Naetar N, Hutter S, Dorner D, Dechat T, Korbei B, Gotzmann J, Beug H, Foisner R. LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit. J Cell Sci. 2007;120(Pt 5):737–47.

13.

Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. Dev Cell. 2007;12(1):17–30.

14.

Chun H-K, Chung K-S, Kim HC, Kang J-E, Kang MA, Kim J-T, Choi EH, Jung K-E, Kim M-H, Song EY, Kim S-Y, Won M, Lee HG. OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers. BMB Rep. 2010;43(20510019):349–54.PubMedCrossRef

15.

Nakamura Y, Tanaka F, Nagahara H, Ieta K, Haraguchi N, Mimori K, Sasaki A, Inoue H, Yanaga K, Mori M. Opa interacting protein 5 (OIP5) is a novel cancer-testis specific gene in gastric cancer. Ann Surg Oncol. 2007;14(17151793):885–92.PubMedCrossRef

16.

Ye Y, Yin D-T, Chen L, Zhou Q, Shen R, He G, Yan Q, Tong Z, Issekutz AC, Shapiro CL, Barsky SH, Lin H, Li J-J, Gao J-X. Identification of Piwil2-like (PL2L) proteins that promote tumorigenesis. PLoS One. 2010;5(10):e13406.

17.

Kimmins S, Kotaja N, Davidson I, Sassone-Corsi P. Testis-specific transcription mechanisms promoting male germ-cell differentiation. Reproduction. 2004;128(15232059):5–12.PubMedCrossRef

18.

Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J. Harrison's principles of internal medicine. 17th ed. New York: The McGraw-Hill Companies, Inc.; 2008.

19.

Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, Drake TA, Lusis AJ. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res. 2006;16:995–1004.PubMedCrossRef

20.

Zhang W, Huang RS, Duan S, Dolan ME. Gene set enrichment analyses revealed differences in gene expression patterns between males and females. Silico Biol. 2009;9(19795565):55–63.

21.

Kaminsky Z, Wang S-C, Petronis A. Complex disease, gender and epigenetics. Ann Med. 2006;38(17438668):530–44.PubMedCrossRef

22.

Wyman MJ, Agrawal AF, Rowe L. Condition-dependence of the sexually dimorphic transcriptome in Drosophila melanogaster. Evolution. 2010;64(20059540):1836–48.PubMedCrossRef

23.

Rivera MP, Stover DE. Gender and lung cancer. Clin Chest Med. 2004;25(15099898):391–400.PubMedCrossRef

24.

Ellegren H, Parsch J. The evolution of sex-biased genes and sex-biased gene expression. Nat Rev Genet. 2007;8(17680007):689–98.PubMedCrossRef

25.

Vesselinovitch SD. The sex-dependent difference in the development of liver tumors in mice administered dimethylnitrosamine. Cancer Res. 1969;29:1024–7.PubMed

26.

Connallon T, Clark AG. Sex linkage, sex-specific selection, and the role of recombination in the evolution of sexually dimorphic gene expression. Evolution. 2010;64(20874735):3417–42.PubMedCrossRef

27.

Reinius B, Shi C, Hengshuo L, Sandhu KS, Radomska KJ, Rosen GD, Lu L, Kullander K, Williams RW, Jazin E. Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. BMC Genomics. 2010;11(21047393):614.

28.

Deschler B, Lübbert M. Acute myeloid leukemia: epidemiology and etiology. Cancer. 2006;107(9):2099–107.PubMedCrossRef

29.

Cheng Y, Buffone MG, Kouadio M, Goodheart M, Page DC, Gerton GL, Davidson I, Wang PJ. Abnormal sperm in mice lacking the Taf7l gene. Mol Cell Biol. 2007;27(17242199):2582–9.PubMedCrossRef

30.

Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci USA. 2008;105(19052232):19384–9.PubMedCrossRef

31.

Slattery SD, Mancini MA, Brinkley BR, Hall RM. Aurora-C kinase supports mitotic progression in the absence of Aurora-B. Cell Cycle (Georgetown, Tex). 2009;8(18):2984–94.

32.

Ulisse S, Delcros JG, Baldini E, Toller M, Curcio F, Giacomelli L, Prigent C, Ambesi-Impiombato FS, D’Armiento M, Arlot-Bonnemains Y. Expression of Aurora kinases in human thyroid carcinoma cell lines and tissues. Int J Cancer. 2006;119(2):275–82.PubMedCrossRef

Titel: Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern
verfasst von: Fatemeh Yazarloo
Reza Shirkoohi
Maryam Beigom Mobasheri
Amirhossein Emami
Mohammad Hossein Modarressi
Publikationsdatum: 01.03.2013
Verlag: Springer US
Erschienen in: Medical Oncology / Ausgabe 1/2013
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-012-0368-8

Springer Medizin

Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2013

The expression of moesin in astrocytoma: correlation with pathologic grade and poor clinical outcome

Impact of the first tumor response at eight weeks on overall survival in metastatic breast cancer patients treated with first-line combination chemotherapy

Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: antitumor efficacies of β-elemene and its synthetic analogs

Frequency of thiopurine S-methyltransferase mutant alleles in indigenous and admixed Guatemalan patients with acute lymphoblastic leukemia

Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia

Association analyses of osteoprotegerin gene polymorphisms with bone mineral density in Chinese postmenopausal women

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie