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Annals of Nuclear Medicine

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01.09.2009 | Original Article

Evaluation of dynamic row-action maximum likelihood algorithm reconstruction for quantitative ¹⁵O brain PET

Erschienen in: Annals of Nuclear Medicine | Ausgabe 7/2009

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Abstract

Objective

A modified version of row-action maximum likelihood algorithm (RAMLA) using a ‘subset-dependent’ relaxation parameter for noise suppression, or dynamic RAMLA (DRAMA), has been proposed. The aim of this study was to assess the capability of DRAMA reconstruction for quantitative ¹⁵O brain positron emission tomography (PET).

Methods

Seventeen healthy volunteers were studied using a 3D PET scanner. The PET study included 3 sequential PET scans for C¹⁵O, ¹⁵O₂ and H ₂ ¹⁵ O. First, the number of main iterations (N _it) in DRAMA was optimized in relation to image convergence and statistical image noise. To estimate the statistical variance of reconstructed images on a pixel-by-pixel basis, a sinogram bootstrap method was applied using list-mode PET data. Once the optimal N _it was determined, statistical image noise and quantitative parameters, i.e., cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral metabolic rate of oxygen (CMRO₂) and oxygen extraction fraction (OEF) were compared between DRAMA and conventional FBP. DRAMA images were post-filtered so that their spatial resolutions were matched with FBP images with a 6-mm FWHM Gaussian filter.

Results

Based on the count recovery data, N _it = 3 was determined as an optimal parameter for ¹⁵O PET data. The sinogram bootstrap analysis revealed that DRAMA reconstruction resulted in less statistical noise, especially in a low-activity region compared to FBP. Agreement of quantitative values between FBP and DRAMA was excellent. For DRAMA images, average gray matter values of CBF, CBV, CMRO₂ and OEF were 46.1 ± 4.5 (mL/100 mL/min), 3.35 ± 0.40 (mL/100 mL), 3.42 ± 0.35 (mL/100 mL/min) and 42.1 ± 3.8 (%), respectively. These values were comparable to corresponding values with FBP images: 46.6 ± 4.6 (mL/100 mL/min), 3.34 ± 0.39 (mL/100 mL), 3.48 ± 0.34 (mL/100 mL/min) and 42.4 ± 3.8 (%), respectively.

Conclusion

DRAMA reconstruction is applicable to quantitative ¹⁵O PET study and is superior to conventional FBP in terms of image quality.

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Titel: Evaluation of dynamic row-action maximum likelihood algorithm reconstruction for quantitative 15O brain PET
Publikationsdatum: 01.09.2009
Erschienen in: Annals of Nuclear Medicine / Ausgabe 7/2009
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-009-0280-2

Springer Medizin

Abstract

Objective

Methods

Results

Conclusion

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