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Annals of Nuclear Medicine

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01.08.2010 | Case Report

FDG-PET/CT in the evaluation of epithelioid hemangioendothelioma of the liver: the role of dual-time-point imaging. A case presentation and review of the literature

verfasst von: Mehmet Tevfik Kitapci, Burcu Esen Akkaş, Ibrahim Gullu, Cenk Sokmensuer

Erschienen in: Annals of Nuclear Medicine | Ausgabe 7/2010

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Abstract

A 46-year-old man with liver lesions referred to us as having “metastases of a malignant mesenchymal tumor” underwent PET/computerized tomography (CT) imaging for the localization of the primary tumor and determination of the extent of disease. No pathological FDG uptake was observed in PET/CT images obtained after 60 min, following FDG injection but delayed PET/CT images demonstrated intense FDG uptake at the liver masses. Since the PET/CT findings were discordant with the initial diagnosis, the pathology specimen was reevaluated and with certain immunohistochemical examinations, the final histopathological decision was changed to epithelioid hemangioendothelioma (EHE). In this report, we discuss the FDG uptake pattern in a patient with hepatic EHE and emphasize the importance of dual-time-point hepatic FDG-PET/CT imaging.

Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982;50(5):970–81.CrossRefPubMed

Ishak KG, Sesterhenn IA, Goodman ZD, Rabin L, Stromeyer FW. Epithelioid hemangioendothelioma of the liver: a clinicopathologic and follow-up study of 32 cases. Hum Pathol. 1984;15(9):839–52.CrossRefPubMed

Makhlouf HR, Ishak KG, Goodman ZD. Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases. Cancer. 1999;85(3):562–82.CrossRefPubMed

Mehrabi A, Kashfi A, Fonouni H, Schemmer P, Schmied BM, Hallscheidt P, et al. Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy. Cancer. 2006;107(9):2108–21 (Review).CrossRefPubMed

Lyburn ID, Torreggiani WC, Harris AC, Zwirewich CV, Buckley AR, Davis JE, et al. Hepatic epithelioid hemangioendothelioma: sonographic, CT, and MR imaging appearances. AJR Am J Roentgenol. 2003;180(5):1359–64.PubMed

Rest CC, Botton E, Robinet G, Conan-Charlet V, Bizais Y, Visvikis D. FDG PET in epithelioid hemangioendothelioma. Clin Nucl Med. 2004;29(12):789–92.CrossRefPubMed

Nguyen BD. Epithelioid Hemangiendothelioma of the liver with F-18 FDG PET imaging. Clin Nucl Med. 2004;29(12):789–92.CrossRef

Lin E, Agoff N. Recurrent hepatic epithelioid hemangiendothelioma detection by FDG PET/CT. Clin Nucl Med. 2007;32(12):949–51.CrossRefPubMed

Läuffer JM, Zimmermann A, Krähenbühl L, Triller J, Baer HU. Epithelioid hemangioendothelioma of the liver. A rare hepatic tumor. Cancer. 1996;78(11):2318–27.CrossRefPubMed

10.

Demetris AJ, Ninervini M, Raikow RB, Lee RG. Hepatic epithelioid hemangioendothelioma: biological questions based on pattern of recurrence in an allograft and tumor immunophenotype. Am J Surg Pathol. 1997;21:263–70.CrossRefPubMed

11.

Munk OL, Bass L, Roelsgaard K, Bender D, Hansen SB, Keiding S. Liver kinetics of glucose analogs measured in pigs by PET: importance of dual-input blood sampling. J Nucl Med. 2001;42:795–801.PubMed

12.

Brix G, Ziegler SI, Bellemann ME, Doll J, Schosser R, Lucht R, et al. Quantification of [(18)F]FDG uptake in the normal liver using dynamic PET: impact and modeling of the dual hepatic blood supply. J Nucl Med. 2001;42(8):1265–73.PubMed

13.

Dirisamer A, Halpern BS, Schima W, Heinisch M, Wolf F, Beheshti M, et al. Dual-time-point FDG-PET/CT for the detection of hepatic metastases. Mol Imaging Biol. 2008;10(6):335–40.CrossRefPubMed

14.

Kuker RA, Mesoloras G, Gulec SA. Optimization of FDG-PET/CT imaging protocol for evaluation of patients with primary and metastatic liver disease. Int Semin Surg Oncol. 2007;4:17.CrossRefPubMed

15.

Nishiyama Y, Yamamoto Y, Fukunaga K, Kimura N, Miki A, Sasakawa Y, et al. Dual-time-point 18F-FDG PET for the evaluation of gallbladder carcinoma. J Nucl Med. 2006;47(4):633–8.PubMed

16.

Akbulut A, Akkas BE, Gokcora N, Karabacak NI, Kitapci MT. The value of late phase imaging with 18F-FDG-PET/CT for liver metastases. Eur J Nucl Med. 2005;Suppl 1:97.

Titel: FDG-PET/CT in the evaluation of epithelioid hemangioendothelioma of the liver: the role of dual-time-point imaging. A case presentation and review of the literature
verfasst von: Mehmet Tevfik Kitapci
Burcu Esen Akkaş
Ibrahim Gullu
Cenk Sokmensuer
Publikationsdatum: 01.08.2010
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 7/2010
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-010-0379-5

Springer Medizin

Abstract

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