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05.04.2017 | Original Article

Age-related effects and gender differences in Japanese healthy controls for [¹²³I] FP-CIT SPECT

verfasst von: Hideo Yamamoto, Shinichi Arimura, Atsushi Nakanishi, Yasushi Shimo, Yumiko Motoi, Koichi Ishiguro, Koji Murakami, Nobutaka Hattori, Shigeki Aoki

Erschienen in: Annals of Nuclear Medicine | Ausgabe 5/2017

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Abstract

Objective

Dopamine transporter (DAT) imaging with [¹²³I]FP-CIT (DaTSCAN) is a widely used diagnostic tool for Parkinsonism and dementia. Since it was approved by the Japanese Ministry of Health, Labor, and Welfare in 2013, there have been no articles focusing on a Japanese normal population. The aim of this study was to examine the effect of aging and gender on DAT availability in Japanese people.

Methods

SPECT imaging of 30 healthy Japanese controls (17 males, 13 females; range 50–86 years, mean 70 years) was performed. SPECT images were reconstructed using a three-dimensional order subset expectation maximization (OSEM) algorithm with correction of the point spread function and scatter correction, without attenuation correction. The specific binding ratio (SBR) was calculated by DATview software. Statistical analyses were performed using linear regression analysis, analysis of variance, and multiple comparison analysis.

Results

A strong correlation between the SBR and age was observed. The correlation coefficient in males and females were −0.566 and −0.502, respectively. The analysis of variance revealed that aging led to a decline of the SBR, and a significant difference (p = 0.005) was observed among generations. Gender also affected the SBR, and there was a significant difference between males and females (p = 0.036). The SBR in females was higher than in males. Consequently, the multiple comparison revealed a significant difference between 50s and 70s (p = 0.015) and 50s and 80s (p = 0.006).

Conclusions

This is the first [¹²³I]FP-CIT SPECT study on subjects with normal dopamine function in Asian countries. This study provides a database of [¹²³I]FP-CIT SPECT in Japanese healthy controls. Higher DAT availability was found in women than in men. An average age-related decline in DAT availability of 8.9% was found in both genders. The data collected in this study would be helpful for Japanese physicians to make a differential diagnosis in Parkinsonian syndrome.

The registration identification number for this study is UMIN000018045.

Nur mit Berechtigung zugänglich

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Titel: Age-related effects and gender differences in Japanese healthy controls for [123I] FP-CIT SPECT
verfasst von: Hideo Yamamoto
Shinichi Arimura
Atsushi Nakanishi
Yasushi Shimo
Yumiko Motoi
Koichi Ishiguro
Koji Murakami
Nobutaka Hattori
Shigeki Aoki
Publikationsdatum: 05.04.2017
Verlag: Springer Japan
Erschienen in: Annals of Nuclear Medicine / Ausgabe 5/2017
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-017-1168-1

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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