nach oben

Oncology Reviews

Erschienen in:

01.12.2010 | Review

Drug-induced QT interval prolongation in cancer patients

verfasst von: Torben K. Becker, Sai-Ching J. Yeung

Erschienen in: Oncology Reviews | Ausgabe 4/2010

Einloggen, um Zugang zu erhalten

Abstract

Cancer patients are at an increased risk for QT interval prolongation and subsequent potentially fatal Torsade de pointes tachycardia due to the multiple drugs used for treatment of malignancies and the associated symptoms and complications. Based on a systematic review of the literature, this article analyzes the risk for prolongation of the QT interval with antineoplastic agents and commonly used concomitant drugs. This includes anthracyclines, fluorouracil, alkylating agents, and new molecularly targeted therapeutics, such as vascular disruption agents. Medications used in the supportive care can also prolong QT intervals, such as methadone, 5-HT₃-antagonists and antihistamines, some antibiotics, antifungals, and antivirals. We describe the presumed mechanism of QT interval prolongation, drug-specific considerations, as well as important clinical interactions. Multiple risk factors and drug–drug interactions increase this risk for dangerous arrhythmias. We propose a systematic approach to evaluate cancer patients for the risk of QT interval prolongation and how to prevent adverse effects.

Casini-Raggi V, Bandinelli G, Lagi A (2002) Vasovagal syncope in emergency room patients: analysis of a metropolitan area registry. Neuroepidemiology 21:287–291CrossRefPubMed

Johnson JN, Ackerman MJ (2009) QTc: how long is too long? Br J Sports Med 43:657–662CrossRefPubMed

Shah M, Akar FG, Tomaselli GF (2005) Molecular basis of arrhythmias. Circulation 112:2517–2529CrossRefPubMed

Yeh ET, Bickford CL (2009) Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol 53:2231–2247CrossRefPubMed

Priori SG, Schwartz PJ, Napolitano C, Bloise R, Ronchetti E, Grillo M, Vicentini A, Spazzolini C, Nastoli J, Bottelli G, Folli R, Cappelletti D (2003) Risk stratification in the long-QT syndrome. N Engl J Med 348:1866–1874CrossRefPubMed

Bednar MM, Harrigan EP, Anziano RJ, Camm AJ, Ruskin JN (2001) The QT interval. Prog Cardiovasc Dis 43:1–45PubMed

Donaldson MR, Yoon G, Fu YH, Ptacek LJ (2004) Andersen-Tawil syndrome: a model of clinical variability, pleiotropy, and genetic heterogeneity. Ann Med 36(Suppl 1):92–97CrossRefPubMed

Crotti L, Celano G, Dagradi F, Schwartz PJ (2008) Congenital long QT syndrome. Orphanet J Rare Dis 3:18CrossRefPubMed

Hedley PL, Jorgensen P, Schlamowitz S, Wangari R, Moolman-Smook J, Brink PA, Kanters JK, Corfield VA, Christiansen M (2009) The genetic basis of long QT and short QT syndromes: a mutation update. Hum Mutat 30:1486–1511CrossRefPubMed

10.

Itoh H, Sakaguchi T, Ding WG, Watanabe E, Watanabe I, Nishio Y, Makiyama T, Ohno S, Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M (2009) Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome. Circ Arrhythm Electrophysiol 2:511–523CrossRefPubMed

11.

Raschi E, Vasina V, Poluzzi E, De Ponti F (2008) The hERG K+ channel: target and antitarget strategies in drug development. Pharmacol Res 57:181–195CrossRefPubMed

12.

Raschi E, Vasina V, Ursino MG, Boriani G, Martoni A, De Ponti F (2010) Anticancer drugs and cardiotoxicity: insights and perspectives in the era of targeted therapy. Pharmacol Ther 125:196–218CrossRefPubMed

13.

Bagnes C, Panchuk PN, Recondo G (2009) Antineoplastic chemotherapy induced QTc prolongation. Curr Drug Saf 5:93–96CrossRef

14.

Pai VB, Nahata MC (2000) Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. Drug Saf 22:263–302CrossRefPubMed

15.

de Forni M, Bugat R, Sorbette F, Delay M, Bachaud JM, Chevreau C (1990) Cardiotoxicity of continuous intravenous infusion of 5-fluorouracil: clinical study, prevention and physiopathology. Apropos of 13 cases. Bull Cancer 77:429–438PubMed

16.

Seymour JF (1993) Induction of hypomagnesemia during Amsacrine treatment. Am J Hematol 42:262–267CrossRefPubMed

17.

Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathofer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J (2004) Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol 142:485–494CrossRefPubMed

18.

Slovacek L, Ansorgova V, Macingova Z, Haman L, Petera J (2008) Tamoxifen-induced QT interval prolongation. J Clin Pharm Ther 33:453–455CrossRefPubMed

19.

Yuill KH, Borg JJ, Ridley JM, Milnes JT, Witchel HJ, Paul AA, Kozlowski RZ, Hancox JC (2004) Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene-without QT interval prolongation. Biochem Biophys Res Commun 318:556–561CrossRefPubMed

20.

Ohnishi K, Yoshida H, Shigeno K, Nakamura S, Fujisawa S, Naito K, Shinjo K, Fujita Y, Matsui H, Sahara N, Takeshita A, Satoh H, Terada H, Ohno R (2002) Arsenic trioxide therapy for relapsed or refractory Japanese patients with acute promyelocytic leukemia: need for careful electrocardiogram monitoring. Leukemia 16:617–622CrossRefPubMed

21.

Ohnishi K, Yoshida H, Shigeno K, Nakamura S, Fujisawa S, Naito K, Shinjo K, Fujita Y, Matsui H, Takeshita A, Sugiyama S, Satoh H, Terada H, Ohno R (2000) Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ann Intern Med 133:881–885PubMed

22.

Youssef G, Links M (2005) The prevention and management of cardiovascular complications of chemotherapy in patients with cancer. Am J Cardiovasc Drugs 5:233–243CrossRefPubMed

23.

Jensen BV (2006) Cardiotoxic consequences of anthracycline-containing therapy in patients with breast cancer. Semin Oncol 33:S15–S21CrossRefPubMed

24.

Schwartz CL, Hobbie WL, Truesdell S, Constine LC, Clark EB (1993) Corrected QT interval prolongation in anthracycline-treated survivors of childhood cancer. J Clin Oncol 11:1906–1910PubMed

25.

Nakamae H, Hino M, Akahori M, Terada Y, Yamane T, Ohta K, Hayashi T, Tsumura K (2004) Predictive value of QT dispersion for acute heart failure after autologous and allogeneic hematopoietic stem cell transplantation. Am J Hematol 76:1–7CrossRefPubMed

26.

Nakamae H, Tsumura K, Akahori M, Terada Y, Yamane T, Hayashi T, Saito I, Kaneko M, Okamoto N, Ichihara Y, Ohta K, Hino M (2004) QT dispersion correlates with systolic rather than diastolic parameters in patients receiving anthracycline treatment. Intern Med 43:379–387CrossRefPubMed

27.

Poprach A, Petrakova K, Vyskocil J, Lakomy R, Nemecek R, Kocak I, Kocakova I, Vyzula R (2008) Cardiotoxicity of drugs used in oncology. Klin Onkol 21:288–293PubMed

28.

Barrett-Lee PJ, Dixon JM, Farrell C, Jones A, Leonard R, Murray N, Palmieri C, Plummer CJ, Stanley A, Verrill MW (2009) Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk. Ann Oncol 20:816–827CrossRefPubMed

29.

Kupari M, Volin L, Suokas A, Timonen T, Hekali P, Ruutu T (1990) Cardiac involvement in bone marrow transplantation: electrocardiographic changes, arrhythmias, heart failure and autopsy findings. Bone Marrow Transplant 5:91–98PubMed

30.

Nakamae H, Tsumura K, Hino M, Hayashi T, Tatsumi N (2000) QT dispersion as a predictor of acute heart failure after high-dose cyclophosphamide. Lancet 355:805–806CrossRefPubMed

31.

Morandi P, Ruffini PA, Benvenuto GM, La Vecchia L, Mezzena G, Raimondi R (2001) Serum cardiac troponin I levels and ECG/Echo monitoring in breast cancer patients undergoing high-dose (7 g/m(2)) cyclophosphamide. Bone Marrow Transplant 28:277–282CrossRefPubMed

32.

Shah MH, Binkley P, Chan K, Xiao J, Arbogast D, Collamore M, Farra Y, Young D, Grever M (2006) Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors. Clin Cancer Res 12:3997–4003CrossRefPubMed

33.

Keller GA, Ponte ML, Di Girolamo G (2009) Other drugs acting on nervous system associated with QT-interval prolongation. Curr Drug Saf 5:105–111CrossRef

34.

Woei Chung L, Liao YM, Hsieh CY, Lin CY (2009) Oxaliplatin-induced long QT syndrome in a patient with appendiceal adenocarcinoma. Acta Oncol 48:156–157CrossRefPubMed

35.

Ewer SM, Ewer MS (2008) Cardiotoxicity profile of trastuzumab. Drug Saf 31:459–467CrossRefPubMed

36.

Heymach JV, Johnson BE, Prager D, Csada E, Roubec J, Pesek M, Spasova I, Belani CP, Bodrogi I, Gadgeel S, Kennedy SJ, Hou J, Herbst RS (2007) Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol 25:4270–4277CrossRefPubMed

37.

Ederhy S, Cohen A, Dufaitre G, Izzedine H, Massard C, Meuleman C, Besse B, Berthelot E, Boccara F, Soria JC (2009) QT interval prolongation among patients treated with angiogenesis inhibitors. Target Oncol 4:89–97CrossRefPubMed

38.

Orphanos GS, Ioannidis GN, Ardavanis AG (2009) Cardiotoxicity induced by tyrosine kinase inhibitors. Acta Oncol 48:964–970CrossRefPubMed

39.

Strevel EL, Ing DJ, Siu LL (2007) Molecularly targeted oncology therapeutics and prolongation of the QT interval. J Clin Oncol 25:3362–3371CrossRefPubMed

40.

Tan-Chiu E, Yothers G, Romond E, Geyer CE Jr, Ewer M, Keefe D, Shannon RP, Swain SM, Brown A, Fehrenbacher L, Vogel VG, Seay TE, Rastogi P, Mamounas EP, Wolmark N, Bryant J (2005) Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast cancer: NSABP B-31. J Clin Oncol 23:7811–7819CrossRefPubMed

41.

Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS (2003) Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. Pharmacotherapy 23:802–805CrossRefPubMed

42.

Almehmi A, Malas AM, Yousufuddin M, Rosencrance JG (2004) Methadone-induced torsade de pointes in a patient with normal baseline QT interval. W V Med J 100:147–148PubMed

43.

Ower K, Morley-Forster P, Moulin D (2005) Fluctuating QTc interval in an asymptomatic patient treated with methadone for chronic pain. J Opioid Manag 1:73–76PubMed

44.

Sticherling C, Schaer BA, Ammann P, Maeder M, Osswald S (2005) Methadone-induced Torsade de pointes tachycardias. Swiss Med Wkly 135:282–285PubMed

45.

George S, Moreira K, Fapohunda M (2008) Methadone and the heart: what the clinician needs to know. Curr Drug Abuse Rev 1:297–302CrossRefPubMed

46.

Anchersen K, Clausen T, Gossop M, Hansteen V, Waal H (2009) Prevalence and clinical relevance of corrected QT interval prolongation during methadone and buprenorphine treatment: a mortality assessment study. Addiction 104:993–999CrossRefPubMed

47.

Wedam EF, Bigelow GE, Johnson RE, Nuzzo PA, Haigney MC (2007) QT-interval effects of methadone, levomethadyl, and buprenorphine in a randomized trial. Arch Intern Med 167:2469–2475CrossRefPubMed

48.

Esses JL, Rosman J, Do LT, Schweitzer P, Hanon S (2008) Successful transition to buprenorphine in a patient with methadone-induced torsades de pointes. J Interv Card Electrophysiol 23:117–119CrossRefPubMed

49.

Fanoe S, Jensen GB, Sjogren P, Korsgaard MP, Grunnet M (2009) Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro. Br J Clin Pharmacol 67:172–179CrossRefPubMed

50.

Benedict CR, Arbogast R, Martin L, Patton L, Morrill B, Hahne W (1996) Single-blind study of the effects of intravenous dolasetron mesylate versus ondansetron on electrocardiographic parameters in normal volunteers. J Cardiovasc Pharmacol 28:53–59CrossRefPubMed

51.

Keefe DL (2002) The cardiotoxic potential of the 5-HT(3) receptor antagonist antiemetics: is there cause for concern? Oncologist 7:65–72CrossRefPubMed

52.

Jo SH, Hong HK, Chong SH, Lee HS, Choe H (2009) H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. Pharmacol Res 60:429–437CrossRefPubMed

53.

Owczuk R, Twardowski P, Dylczyk-Sommer A, Wujtewicz MA, Sawicka W, Drogoszewska B, Wujtewicz M (2009) Influence of promethazine on cardiac repolarisation: a double-blind, midazolam-controlled study. Anaesthesia 64:609–614CrossRefPubMed

54.

Alvarez PA, Pahissa J (2009) QT alterations in psychopharmacology: proven candidates and suspects. Curr Drug Saf 5:97–104CrossRef

55.

Freeman BD, Dixon DJ, Coopersmith CM, Zehnbauer BA, Buchman TG (2008) Pharmacoepidemiology of QT-interval prolonging drug administration in critically ill patients. Pharmacoepidemiol Drug Saf 17:971–981CrossRefPubMed

56.

Jackson T, Ditmanson L, Phibbs B (1997) Torsade de pointes and low-dose oral haloperidol. Arch Intern Med 157:2013–2015CrossRefPubMed

57.

Raghu KG, Singh R, Prathapan A, Yadav GK (2009) Modulation of haloperidol induced electrophysiological alterations on cardiac action potential by various risk factors and gender difference. Chem Biol Interact 180:454–459CrossRefPubMed

58.

Simko J, Csilek A, Karaszi J, Lorincz I (2008) Proarrhythmic potential of antimicrobial agents. Infection 36:194–206CrossRefPubMed

59.

Iannini PB (2002) Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval. Expert Opin Drug Saf 1:121–128CrossRefPubMed

60.

Bril F, Gonzalez CD, Di Girolamo G (2009) Antimicrobial agents-associated with QT interval prolongation. Curr Drug Saf 5:85–92CrossRef

61.

Owens RC Jr, Nolin TD (2006) Antimicrobial-associated QT interval prolongation: pointes of interest. Clin Infect Dis 43:1603–1611CrossRefPubMed

62.

Alexandrou AJ, Duncan RS, Sullivan A, Hancox JC, Leishman DJ, Witchel HJ, Leaney JL (2006) Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin. Br J Pharmacol 147:905–916CrossRefPubMed

63.

Hensey C, Keane D (2008) Clarithromycin induced torsade de pointes. Ir J Med Sci 177:67–68CrossRefPubMed

64.

Barriere S, Genter F, Spencer E, Kitt M, Hoelscher D, Morganroth J (2004) Effects of a new antibacterial, telavancin, on cardiac repolarization (QTc interval duration) in healthy subjects. J Clin Pharmacol 44:689–695CrossRefPubMed

65.

Smith WJ, Drew RH (2009) Telavancin: a new lipoglycopeptide for gram-positive infections. Drugs Today (Barc) 45:159–173CrossRef

66.

Haffner S, Lapp H, Thurmann PA (2002) Adverse drug reactions. QT-prolongation and torsade-de-pointes arrhythmias. Dtsch Med Wochenschr 127:1022–1024CrossRefPubMed

67.

Chakravarty C, Singh PM, Trikha A, Arora MK (2009) Fluconazole-induced recurrent ventricular fibrillation leading to multiple cardiac arrests. Anaesth Intensive Care 37:477–480PubMed

68.

Pham CP, de Feiter PW, van der Kuy PH, van Mook WN (2006) Long QTc interval and torsade de pointes caused by fluconazole. Ann Pharmacother 40:1456–1461CrossRefPubMed

69.

Takemasa H, Nagatomo T, Abe H, Kawakami K, Igarashi T, Tsurugi T, Kabashima N, Tamura M, Okazaki M, Delisle BP, January CT, Otsuji Y (2008) Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome. Br J Pharmacol 153:439–447CrossRefPubMed

70.

Tholakanahalli VN, Potti A, Hanley JF, Merliss AD (2001) Fluconazole-induced torsade de pointes. Ann Pharmacother 35:432–434CrossRefPubMed

71.

Schwartz M, Patel M, Kazzi Z, Morgan B (2008) Cardiotoxicity after massive amantadine overdose. J Med Toxicol 4:173–179CrossRefPubMed

72.

Cortese LM, Gasser RA Jr, Bjornson DC, Dacey MJ, Oster CN (1992) Prolonged recurrence of pentamidine-induced torsades de pointes. Ann Pharmacother 26:1365–1369PubMed

73.

Ernst E (2001) A primer of complementary and alternative medicine commonly used by cancer patients. Med J Aust 174:88–92PubMed

74.

Mao JJ, Farrar JT, Xie SX, Bowman MA, Armstrong K (2007) Use of complementary and alternative medicine and prayer among a national sample of cancer survivors compared to other populations without cancer. Complement Ther Med 15:21–29CrossRefPubMed

75.

Chan CK, Chan MH, Tse ML, Chan IH, Cheung RC, Lam CW, Lau FL (2009) Life-threatening Torsades de Pointes resulting from “natural” cancer treatment. Clin Toxicol (Phila) 47:592–594

76.

O’Brien CE, Harik N, James LP, Seib PM, Stowe CD (2008) Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy 28:1059–1065CrossRefPubMed

77.

Engelstein ED (2003) Long QT syndrome: a preventable cause of sudden death in women. Curr Womens Health Rep 3:126–134PubMed

78.

Letsas KP, Efremidis M, Kounas SP, Pappas LK, Gavrielatos G, Alexanian IP, Dimopoulos NP, Filippatos GS, Sideris A, Kardaras F (2009) Clinical characteristics of patients with drug-induced QT interval prolongation and torsade de pointes: identification of risk factors. Clin Res Cardiol 98:208–212CrossRefPubMed

79.

Abi-Gerges N, Philp K, Pollard C, Wakefield I, Hammond TG, Valentin JP (2004) Sex differences in ventricular repolarization: from cardiac electrophysiology to Torsades de Pointes. Fundam Clin Pharmacol 18:139–151CrossRefPubMed

80.

Drici MD, Clement N (2001) Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome. Drug Saf 24:575–585CrossRefPubMed

81.

Hreiche R, Morissette P, Turgeon J (2008) Drug-induced long QT syndrome in women: review of current evidence and remaining gaps. Gend Med 5:124–135CrossRefPubMed

82.

Locati EH, Zareba W, Moss AJ, Schwartz PJ, Vincent GM, Lehmann MH, Towbin JA, Priori SG, Napolitano C, Robinson JL, Andrews M, Timothy K, Hall WJ (1998) Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: findings from the International LQTS Registry. Circulation 97:2237–2244PubMed

83.

Sze E, Moss AJ, Goldenberg I, McNitt S, Jons C, Zareba W, Qi M, Robinson JL (2008) Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease. Ann Noninvasive Electrocardiol 13:327–331CrossRefPubMed

84.

Arbour L, Rezazadeh S, Eldstrom J, Weget-Simms G, Rupps R, Dyer Z, Tibbits G, Accili E, Casey B, Kmetic A, Sanatani S, Fedida D (2008) A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact. Genet Med 10:545–550CrossRefPubMed

85.

Brink PA, Schwartz PJ (2009) Of founder populations, long QT syndrome, and destiny. Heart Rhythm 6:S25–S33CrossRefPubMed

86.

Heradien M, Goosen A, Moolman-Smook JC, Brink PA (2007) Race and gender representation of hypertrophic cardiomyopathy or long QT syndrome cases in a South African research setting. Cardiovasc J Afr 18:312–315PubMed

87.

Dekker JM, Crow RS, Hannan PJ, Schouten EG, Folsom AR (2004) Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study. J Am Coll Cardiol 43:565–571CrossRefPubMed

88.

Liu JF, Goldenberg I, Moss AJ, Shimizu W, Wilde AA, Hofman N, McNitt S, Zareba W, Miyamato Y, Robinson JL, Andrews ML (2008) Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations. Ann Noninvasive Electrocardiol 13:234–241CrossRefPubMed

89.

Crotti L, Spazzolini C, Schwartz PJ, Shimizu W, Denjoy I, Schulze-Bahr E, Zaklyazminskaya EV, Swan H, Ackerman MJ, Moss AJ, Wilde AA, Horie M, Brink PA, Insolia R, De Ferrari GM, Crimi G (2007) The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: toward a mutation-specific risk stratification. Circulation 116:2366–2375CrossRefPubMed

90.

Wolbrette DL (2004) Drugs that cause Torsades de pointes and increase the risk of sudden cardiac death. Curr Cardiol Rep 6:379–384CrossRefPubMed

91.

Akylbekova EL, Crow RS, Johnson WD, Buxbaum SG, Njemanze S, Fox E, Sarpong DF, Taylor HA, Newton-Cheh C (2009) Clinical correlates and heritability of QT interval duration in blacks: the Jackson Heart Study. Circ Arrhythm Electrophysiol 2:427–432CrossRefPubMed

92.

Schimpf R, Veltmann C, Wolpert C, Borggrefe M (2009) Channelopathies: Brugada syndrome, long QT syndrome, short QT syndrome, and CPVT. Herz 34:281–288PubMed

93.

Stringer J, Welsh C, Tommasello A (2009) Methadone-associated Q-T interval prolongation and torsades de pointes. Am J Health Syst Pharm 66:825–833CrossRefPubMed

94.

Broeyer, FJ, Osanto S, Ritsema van Eck HJ, van Steijn AQ, Ballieux BE, Schoemaker RC, Cohen AF, Burggraaf J (2008) Evaluation of biomarkers for cardiotoxicity of anthracyclin-based chemotherapy. J Cancer Res Clin Oncol 134:961–968

95.

Kaufman ES (2009) Mechanisms and clinical management of inherited channelopathies: long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome. Heart Rhythm 6:S51–S55CrossRefPubMed

96.

Monnig G, Kobe J, Loher A, Eckardt L, Wedekind H, Scheld HH, Haverkamp W, Milberg P, Breithardt G, Schulze-Bahr E, Bocker D (2005) Implantable cardioverter-defibrillator therapy in patients with congenital long-QT syndrome: a long-term follow-up. Heart Rhythm 2:497–504CrossRefPubMed

97.

Hobbs JB, Peterson DR, Moss AJ, McNitt S, Zareba W, Goldenberg I, Qi M, Robinson JL, Sauer AJ, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Towbin JA, Vincent GM, Zhang L (2006) Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome. JAMA 296:1249–1254CrossRefPubMed

98.

Krahn AD, Yee R, Chauhan V, Skanes AC, Wang J, Hegele RA, Klein GJ (2002) Beta blockers normalize QT hysteresis in long QT syndrome. Am Heart J 143:528–534CrossRefPubMed

99.

Priori SG, Napolitano C, Schwartz PJ, Grillo M, Ronchetti E, Moncalvo C, Tulipani C, Veia A, Bottelli G, Nastoli J (2004) Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers. JAMA 292:1341–1344CrossRefPubMed

100.

Proclemer A, Ghidina M, Facchin D, Rebellato L, Corrado D, Gasparini M, Gregori D (2009) Use of implantable cardioverter-defibrillator in inherited arrhythmogenic diseases: data from Italian ICD Registry for the years 2001–2006. Pacing Clin Electrophysiol 32:434–445CrossRefPubMed

Titel: Drug-induced QT interval prolongation in cancer patients
verfasst von: Torben K. Becker
Sai-Ching J. Yeung
Publikationsdatum: 01.12.2010
Verlag: Springer Milan
Erschienen in: Oncology Reviews / Ausgabe 4/2010
Print ISSN: 1970-5557
Elektronische ISSN: 1970-5565
DOI: https://doi.org/10.1007/s12156-010-0058-8

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Drug-induced QT interval prolongation in cancer patients

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2010

Screening of high-risk groups for breast and ovarian cancer in Europe: a focus on the Jewish population

Photofrin-mediated photodynamic therapy for treatment of early stage laryngeal malignancies

Vγ9Vδ2 T cells as a promising innovative tool for immunotherapy of hematologic malignancies

Clinicopathologic characteristics of primary pleural epithelioid hemangioendothelioma

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie