Cervical epidural steroid injections in the management of cervical radiculitis: interlaminar versus transforaminal. A review

Rowlingson and Kirschenbaum [19] retrospectively present their results on 25 subjects with cervical radiculopathy who underwent 45 blind interlaminar CESI at C6-7 or C7-T1. Advanced imaging with CT and/or Myelography was performed in only 12 of the subjects. A compressive lesion was found in nine. Whether the compressive lesion correlated with the subject’s symptoms was not stated. Average follow-up was 8.9 months. Excellent response defined as complete resolution of symptoms occurred in 24%. Symptom improvement of greater than 75% occurred in 40%. Three subjects had no improvement.

Mangar and Thomas [20] briefly report their results for 40 subjects who underwent 117 blind interlaminar CESI for cervical radiculitis. Greater than 70% pain relief and more than 50% relief were reported in 38% and 7%, respectively. No relief occurred in 32%. However, 75% of subjects with herniated disk had improvement. Time from treatment to analysis was not reported in this retrospective review.

Ferrante et al. [21] retrospectively analyzed records of 100 subjects who underwent 235 blind midline interlaminar CESI for radicular or axial pain. Of those with radiculopathy, 62% had greater than or equal to 50% pain relief. Of those with cervical radiculitis with structural abnormality on imaging, only 35% had 50% or better pain relief.

Stav et al. [22] performed a prospective, randomized trial of blind interlaminar CESI (group A), posterior muscle trigger point with steroid:anesthetic mixture (group B), and intra-muscular lidocaine injection (group C). Group C consisted of 10 subjects who were later divided equally into groups A and B. Groups A and B initially consisted of 25 subjects each, but 8 in group B were later excluded secondary to litigation. Inclusion was neck and neck with radicular pain from cervical disk disease or spondylosis that failed physical therapy and medications. Groups A and B received 3 injections performed every 2 weeks. Outcome was considered very good for 75% decrease and good for 50–74% decrease in VAS. At 1 year, very good or good relief was 68% and 11.8% for groups A and B, respectively. Group C had poor results in all subjects at 3–4 week follow-up. The results suggest benefit from CESI.

The observational studies suggest a success rate of 40–62% for blind, interlaminar CESI for cervical radiculopathy. The one prospective, randomized trial demonstrated superiority of blind, interlaminar CESI over trigger point injection for radicular pain. However, the actual diagnosis of subjects in these studies is elusive. Treatment outcomes will be dependent upon a specific diagnosis. Mangar and Thomas [20] support this premise noting 75% of subjects with a herniated disk had improvement, while overall success rate in their study was only 45%.

For blind, interlaminar CESI only two studies were performed for a specific diagnostic group. Chemical radiculitis is defined as radicular pain in the absence of nerve root compression on imaging studies [23]. Castagnera et al. [24] randomized 24 subjects suffering from cervical chemical radiculitis treated with blind interlaminar CESI with steroid/lidocaine combination versus interlaminar CESI with steroid/morphine sulfate combination. At 3 months, there was no difference between groups with mean VAS decrease of 87% for both groups. The authors concluded there is no advantage to the addition of morphine to CESI. Grenier et al. [25] prospectively report on 29 subjects who underwent one blind interlaminar CESI at C7-T1 for chemical radiculitis with 83% success rate at 3 month follow-up that remained for 2 years.

Blind, interlaminar CESI may be misplaced 53% of the time utilizing the loss of resistance technique [26]. Hence, studies performed with blind, interlaminar CESI have been criticized for probably underestimating efficacy. Fluoroscopy with conformation utilizing non-ionic contrast agent has been advocated to improve accuracy of interlaminar CESI’s [26].

Bush and Hillier [27] prospectively evaluated with an independent review of 68 consecutive subjects suffering from cervical radiculopathy. Cervical spondylosis was present in 30% and herniated disk in 70% of subjects. Subjects received a cervical brachial plexus block. If no relief the subjects progressed to fluoroscopically guided transforaminal CESI and lastly, fluoroscopically guided interlaminar CESI. Twenty-nine percent had relief with brachial plexus injection, 62% with transforaminal CESI, and 16% interlaminar CESI. At mean follow-up of 39 months (range 4–112), 76% had complete relief of arm pain and 24% had average pain score of 2. Prior to treatment 75% had weakness. At follow-up 73% no longer experienced weakness. Eighty-four percent did not feel their symptoms interfered with their capacity to work.

Bush et al. [5] prospectively reported on 13 subjects with cervical radiculopathy from HNP that received either a blind injection, fluoroscopically guided transforaminal CESI or interlaminar CESI. An average follow-up of 12 months (range, 4–31 months) underwent telephone interview and repeat MRI. Twelve of thirteen had resolution of the herniated nucleus pulposus. The one subject with persistent herniated nucleus pulposus on MRI had residual neck pain.

While the above studies suggest CESI’s are beneficial in the management of cervical radicular pain from a herniated disk, the lack of a control group does not exclude the improvement being secondary to the favorable natural history of cervical disk herniation. Saal et al. [28] experienced an 83% success rate for non-operative management of radiculopathy from a cervical disk herniation in 26 subjects. Treatment consisted of relative rest, modalities, hard cervical collar, medications, and physical therapy. Nine subjects with persistent symptoms underwent either fluoroscopically guided interlaminar or transforaminal CESI. Follow-up was over 1 year in all subjects.

Fluoroscopy allowed the development of transforaminal CESI’s. Transforaminal epidural injections have the advantage of being able to place medication directly around the dorsal root ganglion pathologically involved in causing a patient’s radicular pain. Medication in the epidural space will tend to flow in the direction of least resistance. With interlaminar paramedian cervical epidural injections, the medication tends to spread unilateral in 51% and ventral in only 28% [26]. The authors utilized a 2-ml volume stating larger volumes could result in dilution of corticosteroid at the site of pathology. In a separate study with a midline approach, ventral flow occurred in 44.6% of epidural injections with volumes ranging from 2 to 4 ml [29]. Foraminal and entrance zone disk herniations, cervical spondylotic foraminal stenosis, and epidural fibrosis can potentially block the flow of medication from an interlaminar epidural injection to the involved dorsal root ganglion. Hence, interventionalists seeking to improve efficacy began to perform transforaminal epidural steroid injections to put medication at the site of pathology.

Anderberg et al. [30] performed a prospective, randomized study of radicular pain from cervical spondylosis with positive MRI finding and 50% or greater relief with diagnostic selective nerve root injection. Subjects were randomized to receive either 0.5 ml Carbocain and 1 ml steroid (40 mg methylprednisolone) or 0.5 ml Carbocain and 1 ml saline transforaminal cervical epidural injection with fluoroscopic guidance. Follow-up was performed at 3 weeks. Twenty subjects were in each group with subjective improvement in pain occurred in 8 in the steroid group and 7 in the saline group. There was no statistical significance between groups.

Vallee et al. [31] prospectively evaluated transforaminal CESI performed on 32 consecutive subjects with radicular pain from foraminal stenosis either from spondylosis or disk herniation. At 6 months follow-up greater than 50% relief occurred in 56% who also resumed full activities.

Cyteval et al. [32] report on 30 subjects with cervical radiculopathy from either spondylotic foraminal stenosis (16 subjects) or foraminal disk protrusion (14 subjects). All subjects had persistent symptoms despite 1 month of physical therapy and medication management. Subjects underwent one CT-guided transforaminal CESI. Eighteen subjects had good to excellent pain relief at 2 weeks with average VAS decreasing from 6.3 to 1.2. At 6 months these 18 subjects had mean VAS of 0.7. For the 12 subjects with fair or poor results at 2 weeks, 3 had a second CT-guided transforaminal CESI. At 2 weeks from the second injection 2 subjects had greater than 75% relief (excellent) and 1 with less than 25% relief (poor).

Slipman et al. [33] retrospectively evaluated 22 subjects with radicular pain without a compressive lesion on imaging studies following a motor vehicle accident. All subjects had at least 80% pain reduction from a diagnostic cervical selective nerve root injection. Additionally, all subjects had greater arm than neck pain. Mean follow-up was 33.3 months (range 4–65 months). An average of 2.1 injections was performed. A steroid effect occurred in 59%. Only 14% had a good to excellent outcome, based upon VAS, Oswestry, work status, and medication usage. Average Oswestry score at presentation and follow-up was 45.5 and 40.7, respectively. Average VAS score at presentation and follow-up was 73.3 and 50.7, respectively. However, high functioning at time of presentation had a more favorable outcome statistically with 48.9% improvement in pain and continued high functional status. The authors concluded transforaminal CESI was not indicated in this group except for possibly higher functioning individuals at presentation.

Slipman et al. [34] retrospectively report only 20% with good to excellent outcome with mean follow-up of 20.7 month for transforaminal CESI in 15 subjects for traumatically induced cervical spondylotic radicular pain. In these subjects with cervical spondylotic foraminal stenosis, symptoms occurred following a traumatic incident. Motor vehicle accident accounted for 46.7%, fall 13.3%, lifting injury 20%, and sport injury 20%. The authors concluded the use of transforaminal CESI is not supported in this group.

Slipman et al. [35] retrospectively present 20 subjects that underwent transforaminal CESI for radicular pain due to non-traumatic cervical spondylotic foraminal stenosis. Follow-up was done at an average of 21.2 months (range, 12–45 months) with subjects receiving an average of 2.2 injections. Sixty percent had good to excellent results. Pain decreased from VAS score 6.9 to verbal numeric scale score of 2.0. There was no significant change in employment status but significant decrease of medication usage.

Lin et al. [36] retrospectively reported on 70 consecutive subjects that underwent transforaminal CESI for radicular pain from a herniated cervical disk. All patients had been offered surgical treatment but given the option of a transforaminal CESI. Mean follow-up was 13 months (range, 6 months to 4 years) with 65.3% good to excellent relief with Odom criteria and avoidance of surgery. The authors found more favorable result in those over age 50 and symptom duration less than 100 days.

The above observational studies with cervical transforaminal ESI suggest benefit for radicular pain due to non-traumatic spondylotic stenosis and herniated disk [31, 35, 36]. However the lack of a control group does not exclude a favorable natural history. The studies also suggested transforaminal CESI is not beneficial in those with chemical radiculitis or cervical spondylotic foraminal stenosis following a motor vehicle accident [33, 34]. The one randomized, prospective study was poorly designed [30]. A validated outcome measure was not utilized. For pain relief, any pain improvement at the 3 week follow-up was included. A subject with only 10% relief would be included in the same group as one with 90% relief. Only short-term outcome was measured. Also, local anesthetic has anti-inflammatory effect and improves radicular flow both therapeutic benefits. Clinically, patients may receive from one to four therapeutic injections in a treatment regimen not just one. Nevertheless, prospective, randomized controlled trials are needed to determine the effectiveness of CESI in the management of radicular pain from herniated disk and spondylotic foraminal stenosis.

A randomized controlled trial of perineural injection was found to be superior to inter-laminar epidural injection in radiculitis from herniated lumbar disk [37]. A retrospective study also found lumbar transforaminal epidural steroid injections had superior pain reduction than inter-laminar epidural steroid injections at short term and less surgical interventions at 1 year review [38]. These studies support the benefits of target-specific injection. However, studies of the lumbar spine cannot necessarily be extrapolated to the cervical spine. There are currently no prospective studies in the English literature comparing the effectiveness of transforaminal versus interlaminar CESI for specific diagnostic groups.

Waldman [58] prospectively reported upon complications with blind interlaminar C5-6 or C6-7 epidural steroid injections utilizing loss of resistance technique on 215 subjects receiving 790 injections. Complications were recorded immediately at 6 weeks by the pain management physician or nurse. Two individuals suffered dural puncture with headache requiring blood patching. There were 3 vasovagal reactions and one superficial infection.

Botwin et al. [59] retrospectively reported complications with fluoroscopically guided C6-7 or C7-T1 interlaminar epidural steroid injections on 157 subjects receiving 345 injections. Data were obtained at 24 h from the ambulatory surgical center questionnaire and 3 week physician follow-up. There was 6.7% neck pain, 4.6% non-positional headache, 1.7% insomnia, 1.7% vasovagal reaction, 1.5% facial flushing, 0.3% fever, and 0.3% dural puncture incidence. The overall rate of complications was 16.8%.

Ma et al. [52] reviewed records of 1,036 cervical transforaminal epidural steroid injections in 844 subjects. Immediate complications were recorded by the radiologist performing the procedure. If any complications occurred after discharge, the subjects were told to contact their referring physician. Hence, complications that occurred after discharge are at risk of being underreported. The authors’ report complications occurred in 14 subjects (1.66%). These included headache/dizziness (0.59%), transient pain or weakness (0.71%), hypersensitivity reaction (0.12%), transient global amnesia (0.12%), vasovagal reaction (0.12%), and wrong site injection (0.36%).

Huston et al. [53] performed a prospective, controlled study with independent interviewer of lumbar and cervical selective nerve root injections on 151 subjects who received 306 injections. The control group was 60 subjects with similar demographics and spinal complaints that did not undergo an intervention at time of interview. Procedural complications were recorded by the interventionalist. Immediate, 1 week and 3 month complications were recorded by an independent interviewer. Of the cervical group, there were 89 cervical selective nerve root injections performed on 37 subjects. There were no major complications. There was one dural puncture but the subject did not develop a headache and no treatment was needed. In the cervical group immediate complications were increased pain at injection site 22.7%, increased radicular pain 18.2%, lightheadedness 13.6%, increased spine pain 9.1%, non-specific headache 4.5%, and nausea 3.4%. One week follow-up compared to the control group had significance for increased pain at injection site (P = .001), non-specific headache (P = .019), and non-spinal headache (P = .002). At 3 months follow-up 2 subjects complained of increased neck pain. One would repeat the injections again. The other subject would not repeat the injection. This subject did have complete resolution of radicular pain from a herniated disk but was not satisfied because of persistent neck pain.

Incidence of dural puncture with interlaminar CESI ranges from 0.25% to 2.00% [21, 58, 60] and transforaminal CESI 1.12% [53]. With dural puncture the procedure is discontinued to avoid subarachnoid instillation of local anesthetic or corticosteroid. Instillation of local anesthesia could result in spinal anesthesia with respiratory depression, hypotension, and syncope [61]. Additionally, subarachnoid corticosteroid injection has been hypothesized to cause arachnoiditis [62, 63]. Celestone Chronodose has been evaluated in sheep and found to result in arachnoiditis at suprapharmacologic levels [64]. Epidural injections of triamcinolone and methyprednisolone in animal studies did not result in arachnoiditis or nerve root injury [65, 66].

After dural puncture, there is still the concern of spinal headache. However, dural puncture does not always result in a spinal headache [53, 58, 60, 61]. If a headache does occur, treatment may consist of strict bed rest, hydration, analgesics, and caffeine [67]. For severe or persistent headache interlaminar or transforaminal blood patching may be performed [58, 68].

The risk of dural puncture may be higher with an interlaminar than a transforaminal approach. Cryomicrotome studies of the cervical epidural space report absence of the posterior epidural space above C7-T1. In another study, the posterior epidural space at C5 has been reported at 1–1.5 mm [69]. Furthermore, there is an absence of the interspinous ligament in the cervical spine [69] along with half of specimens being deficient in the midline of the ligamentum flavum. Hence, blind injections utilizing loss of resistance technique may inadvertently puncture the dura. With transforaminal CESI, utilizing multi-planar imaging should avoid inadvertent dural puncture. On the AP view, the needle should not be advanced beyond the 6 o’clock (midline) position of the lateral mass. Dural puncture typically occurs by advancing the needle too far in the oblique plane. The technique section will discuss the need for frequent multi-planar imaging while advancing the spinal needle.

Non-positional headaches occurred with cervical selective nerve root injections in 4.5% and was found to be statistical significant when compared to a control population [53]. For fluoroscopically guided interlaminar CESI, non-positional headache occurred in 4.6%. The rate is comparable between the two techniques. These headaches have been attributed to alterations in CSF pressure which is related to rapid injection and/or higher volumes [70, 71]. These headaches are typically transient and respond to oral analgesics. These headaches can be minimized by injecting slowly and the use of lower volumes.

Transient blindness after epidural steroid injection has been reported primarily with lumbar interlaminar and caudal injections. However, Kao [47] reported a case of impaired visual acuity following a C6-7 interlaminar ESI with 4 ml lidocaine and 2 ml triamcinolone. Five days after the second CESI, the patient developed headache, vomiting, neck stiffness, and decreased left visual acuity. A serous retinal detachment was found. The detachment resolved after 4 weeks but still with impaired vision. By 4 months, the patient reported normal vision. The cause of the retinal detachment is unknown. The author hypothesizes the following possibilities: (1) stress during the injection resulted in neuroendocrine alteration, (2) corticosteroid may have damaged the choroicapillaris with altered permeability, and (3) the corticosteroids may have elevated cathecholamine levels resulting in constriction of choroids vessels. If due to the steroids, then any utilization of corticosteroid whether oral, intra-muscular, or epidural with systemic absorption could potentially result in retinal detachment. Another possibility is increased CSF pressures which could explain the headache and vomiting the patient experienced. While the volume was 6 ml, rapid instillation could increase CSF pressures.

Bilateral retinal hemorrhages with transient blindness after caudal and lumbar ESI has been reported [72‐75]. The retinal hemorrhages were felt to be related to increased CSF pressure created by rapid instillation and large volumes of medication injected with ESI [72, 73]. Volumes of 20 ml can increase CSF pressures [72]. Volumes of lidocaine and bupivicaine have ranged from 2 to 20 ml with cervical interlaminar ESI [21, 58, 76]. Larger volume CESI’s with rapid instillation should be avoided.

Cushing’s syndrome has been reported after interlaminar CESI with 60 mg of methylprednisolone [45]. The syndrome resolved after 12 months. Cushing’s syndrome has also been reported after lumbar ESI. While Cushing’s syndrome has not been reported with transforaminal ESI, the occurrence is probably related to the systemic absorption of the corticosteroid as opposed to the technique of delivery. Additionally, systemic affects of corticosteroids can result in hyperglycemia in diabetics and needs to be closely monitored.

Infection is always a risk whenever the skin is punctured. Huang et al. [51] present a case of epidural abscess following CESI. The patient initially presented with increased neck pain and chills. The patient subsequently developed left arm pain, paresthesia, and weakness but was neurologically intact in the lower extremities. An epidural abscess from C4 to C6 was seen on gadolinium-enhanced MRI. The patient underwent surgical decompression, irrigation, and debridement. The patient was placed on intravenous antibiotics. By 7 months post-operative, the patient regained baseline neurologic function [51]. Whether one technique is more predisposed is unknown. The procedure should be done with sterile technique. Additionally, the interventionalist should not touch the spinal needle tip. Both techniques are at risk for infection.

Nerve root injury and transient paresthesias have been reported after interlaminar CESI [46, 60]. After a blind interlaminar C5-6 ESI, nerve root injury was postulated as the initial injury resulting in complex regional pain syndrome [50]. For cervical selective nerve root injections transient increased radicular pain occurred in 18.2% but with no episodes of nerve root injury [53].

Epidural hematoma after fluoroscopically guided C5-6 interlaminar CESI requiring surgical evacuation has been reported [42]. The patient had near full recovery of paralysis. Another case occurred within half and hour after painful paresthesia with the introduction to a Touhy needle at the C6-7 interspace [43]. The patient had incomplete recovery prior to surgery with high-dose intravenous methylprednisolone. The patient also required immediate surgical evacuation of the hematoma. Puncturing of the epidural venous plexus is the probable etiology. Whether the risk of epidural hematoma and subsequent quadriplegia is greater with interlaminar versus transforaminal CESI is unknown. However, with tranforaminal injections the needle is not placed directly into the spinal canal. Puncturing a radicular vein or artery within the foramen may be less likely to result in thrombosis formation with cord compression as the needle is not within the spinal canal. However, there may be other serious consequences of vascular puncture with transforaminal injections.

Brouwers [54] reported a case of tetraplegia following a right C6 transforaminal ESI with bupivicaine/triamcinolone mixture. The paralysis was consistent with anterior spinal artery syndrome. Another case was reported of cord infarction after left C6 transforaminal ESI with the patient suffering incomplete tetraplegia [56]. In another case, digital subtraction revealed puncture of a radicular artery terminating with several branches in the region of the spinal cord despite correct technique with a transforaminal cervical epidural injection [77]. The procedure was done with live fluoroscopy when injecting contrast. Fortunately, the procedure was abandoned without sequelae after noting the vascular flow. Tiso et al. [57] reported a case of cerebellar infarction after a C6 transforaminal CESI with bupivicaine/triamcinolone mixture. Intra-vascular injection of particulate steroid resulting in embolic occlusion through the vertebral artery with subsequent infarction was postulated as the cause. Pathology revealed bilateral cerebellar and occipital cortex infarction, thromboembolism of the leptomeningeal artery.

Light microscopy of steroid particulate size found up to 50 µm particle size for methylprednisolone, triamcinolone, betamethasone sodium phosphate and acetate, dexamethasone, and betamethasone sodium phosphate [57]. Only betamethasone sodium phosphate had no particles greater than 50 µm. Less than 5% of particles were greater than 50 µm for methylprednisolone, betamethasone sodium phosphate and acetate, and dexamethasone. Methylprednisolone and triamcinolone had a tendency to coalesce into large aggregates of greater than 100 µm, which could result in sludging [57]. Particle and aggregate size is relevant when one considers the diameter of the artery system: artery >50 µm, metarteriole 20–50 µm, arteriole 10–15 µm, and capillary 5–8 µm. Based upon dimensions, methylprednisolone and triamcinolone sludge could block smaller arteries and arterioles and result in ischemia [57]. Dexamethasone and betamethasone sodium phosphate would be better choices to avoid vascular occlusion. However, betamethasone sodium phosphate is not available commercially. While betamethasone sodium phosphate can be obtained through a compounding pharmacy, it is not recommended. Meningitis with subsequent death has been linked to compounding pharmacies making betamethasone sodium phosphate [78]. Hence, at this time, the corticosteroid recommended for transforaminal CESI is commercially available dexamethasone [57]. Furthermore, there was no statistical significance difference between outcomes with dexamethasone versus triamcinolone for cervical radicular pain [79].

Temporary paralysis was reported after a diagnostic C7 transforaminal injection with 0.8 ml 2% lidocaine [80]. Sixty-seconds after injection the patient felt unwell. In the next 2–3 min the patient developed quadraparesis that resolved after 20 min. The neurologic deficits were consistent with anterior spinal artery syndrome. The authors recommend injecting local anesthetic first and separate from the steroid [80].

The current hypothesis of tetraplegia following transforaminal epidural steroid injection relates to arterial injection of corticosteroid into a radiculomedullary artery with subsequent occlusion. The radiculomedullary arteries are major feeders to the anterior spinal artery. These arteries can arise anywhere from C3 to C8. Occlusion of a radiculomedullary artery can result in spinal cord infarction—anterior spinal artery syndrome. While vertebral artery puncture should be avoided by adhering to correct technique, Baker et al. [77] demonstrated a correct technique which can still result in injection into a radicular artery. When performing a transforaminal CESI, the following are modified recommendations to minimize the chance of radicular artery injection of corticosteroid [77]: (1) once the needle is in place, tubing should be connected to the spinal needle hub and syringe. This is to prevent inadvertent needle movement when attaching different syringes of injectate. (2) Injection of contrast under live fluoroscopy—evaluating for any vascular flow. Digital subtraction imaging may be of benefit. [3] If no vascular flow with contrast, then proceed to injection of local anesthetic under live fluoroscopy. The patient is then monitored for at least 90 s. This is based upon the case report of Karasek and Bogduk [80] in which initial symptoms of radicular artery injection of local anesthetic occurred at 1 min and paralysis in 2 min. After the time interval expires, the patient should be asked about a metallic taste, peri-oral numbness, auditory changes, agitation suggesting local anesthetic toxicity. Additionally pin-prick is tested in the hands and lower extremities along with movement of the hands and feet. If no signs are present to suggest anterior spinal artery syndrome or intra-arterial injection, then proceed to step 4. (4) Before injecting dexamethasone, confirm needle placement has not changed utilizing fluoroscopy. Then slowly inject dexamethasone.

The occurrence of tetraplegia has opened the debate of whether transforaminal or interlaminar CESI should be performed. However, tetraplegia has occurred after interlaminar CESI. Cord injury following two cases of fluoroscopically guided interlaminar C5-6 ESI occurred in sedated patients [81]. The authors suggested the sedation did not allow the patients to respond to cord penetration by the needle. However, needle penetration of the cord in alert patients can be without pain or paresthesias [82]. While cord puncture may not be painful, injection of contrast agent into the cord produced pain [83]. Tetraplegia followed a fluoroscopically guided C6-7 interlaminar ESI [84]. While the cause is unknown, the authors hypothesized ischemic injury to the cord [84]. Bromage and Benumof reported a case of paralysis consistent with anterior artery syndrome in an individual undergoing spinal epidural anesthesia at T12 [85]. While the cause was unknown, the case report raised caution in epidural injections performed above the termination of the cord [85].

The cord is at risk of puncture with interlaminar CESI. The ligamentum flavum in the cervical region was found to be deficient in the midline in half of specimens [69]. Furthermore, the interspinous ligament is absent in the cervical spine [69]. When utilizing a loss of resistance technique, lack of resistance from absence of the interspinous ligament and unfused ligamentum flavum could lead to inadvertent dural and cord puncture. Performing the procedure under fluoroscopic guidance should help avoid inadvertent cord penetration.

Both interlaminar and transforaminal CESI’s have case reports of catastrophic neurologic complications and death. The incidence of these complications while felt to be rare is unknown. Derby et al. [86] surveyed instructors of the International Spine Intervention Society. While not scientific, the survey revealed no major complication, no paralysis or death, in 4,389 interlaminar and 1,579 transforaminal injections. A national databank of complications would be helpful in determining the incidence of rare complications. This would be helpful in developing safer techniques and in appropriate consenting of patients undergoing CESI’s. This system would be beneficial for the continuous improvement of patient care. Unfortunately, the current medical malpractice legal climate in the United States creates challenges in developing such a system.

Understanding cervical spine anatomy is imperative to the interventionalist performing cervical spine procedures. The epidural space is a triangular space extending from the foramen magnum to the sacral hiatus. The inner border is the thecal sac—dura mater. The outer border is the bony spinal canal and the covering periosteum. The anterior border is the posterior longitudinal ligament. The posterior border is the lamina and ligamentum flavum. The lateral border is the pedicle and intervertebral foramen. The epidural space contains loose areolar tissue, venous plexus, spinal nerve roots, radicular arteries, superficial and deep cervical arteries, arachnoid granules, and lymphatics. Above C7-T1 no posterior epidural space was evident on study [69]. The ligamentum flavum is unfused in the midline in approximately half of individuals and the interspinous ligament is absent [69].

Rootlets arise from the cord to form ventral and dorsal nerve roots which exit with the thecal sac covered with dura—the root sleeve. The dura ends at the proximal margin of the dorsal root ganglion. The ventral and dorsal roots coalesce to form the spinal nerve that exits from the foramen. The dura extends as the epiradicular sheath covering the dorsal root ganglion and spinal nerve. The spinal nerve is located in the inferior aspect of the foramen.

The foramen is formed by the superior and inferior pedicle. The superior articular process of the zygapophyseal joint forms the posterior wall. The anterior wall is superior vertebral endplate and disk.

The spinal nerve is posterior to the vertebral artery [89]. The vertebral artery arises from the subclavian and enters the costotransverse foramen at C6 and exits at C1 but can enter at C5 [90]. The vertebral artery crosses posterior to C1 arch before entering the skull through the foramen magnum. Branches from the vertebral artery descend forming the anterior spinal artery. The anterior spinal artery is divided into cervical, thoracic, and lumbar segments [89]. Spinal arteries arising from the vertebral, subclavian, and ascending cervical and deep cervical arteries enter through the foramen and divide into the anterior and posterior cervical radicular arteries [90]. Most radicular arteries supply the nerve root. A variable number of anterior radicular arteries supply the anterior spinal artery. These radicullomedullary arteries are larger and may ascend and descend within the thecal sac supplying the anterior spinal artery. In the cervical region a variable number of radicullomedullary arteries are present and may enter anywhere from C3 to C8 [91, 92] The radicular arteries and radicullomedullary arteries may be located posterior to the spinal nerve in the posterior-inferior aspect of the foramen, close to the target zone of transforaminal injections [90].

The patient is placed in a prone position on the fluoroscopy table with arms at the side. A blanket is placed under the chest. The neck is flexed with the head resting on a folded towel or blanket. To help prevent movement the head may be held in place with a Velcro strap though not all practitioners do this. The neck is prepped and draped in the usual sterile manner and sterile technique is utilized throughout the procedure. AP view is obtained to ensure the C7-T1 interspace located and the patient is correctly positioned in a true AP view. A skin wheal is raised with a 10:1 mixture of 1% lidocaine and 8.4% bicarbonate. A 20–22 gauge Touhy needle is directed in the midline with a tunnel view parallel to the trajectory of the spinous processes. Once purchase of the needle in the paraspinal muscles occurs, a lateral view is obtained. A syringe containing normal saline is attached to the Touhy needle. Maintaining the same trajectory, the needle is advanced in the lateral plane checking for loss of resistance. The needle should not be advanced beyond the spinolaminar line. Advancing beyond this line risks dural and cord puncture. Additionally, loss of resistance may not occur despite entering the epidural space [93]. If the patient develops pain or paresthesias suggesting cord puncture or nerve root puncture, the needle should be withdrawn and the procedure abandoned. Contrast should not be injected as intra-cord instillation could be catastrophic [81]. More specifically, if cord puncture occurred, then dural puncture also occurred. Once loss of resistance occurs or the needle tip is at the spinolaminar line, needle advancement should stop. Position of the needle is checked in both the AP and lateral plane to ensure the needle is midline and at or only slightly beyond the spinolaminar line. A syringe contained non-ionic contrast (Isovue or Omnipaque) is attached to low volume extension tubing and flushed. Prior to attaching the extension tubing, a drop of contrast is placed in the Touhy needle to flush out any air. Then under live fluoroscopy contrast is injected evaluating for epidural flow and ensuring no vascular pattern. If a venous pattern occurs, the needle is withdrawn and repositioned. If an arterial pattern occurs, the procedure should be abandoned. If a myelographic pattern is obtained indicating subarachnoid injection, the procedure is abandoned [93]. Contrast should flow epidurally along the spinolaminar line creating a dorsal stripe [94]. Then under live fluoroscopy 2 cc of 1% lidocaine and 2 cc Dexamethasone is slowly infused. While the risk of radicular artery cannulation is probably lower for interlaminar injection, one may err on the side of caution and inject local anesthetic and steroid separately.

The patient is placed in the supine-oblique position on the fluoroscopy table. A towel or blanket is placed under the head to keep the neck parallel to the table. The patient is rolled into the correct position with the foramen perpendicular to the radiographic imager. A bolster is then placed behind the patient to support this position. The patient is prepped and draped in a sterile fashion and sterile technique is utilized throughout the procedure. Before starting, the interventionalist should review the image to visualize the target and path of the needle. One should visualize the path of the vertebral artery on the fluoroscopic image. If the patient’s position is too oblique, the vertebral artery may be in the path of the needle. If too lateral, attempts to advance the needle into the foramen will result in anterior placement of the needle, risking vertebral artery puncture. Proper patient positioning is paramount. Once correctly positioned, a skin wheal is raised with 10:1 mixture of 1% lidocaine and 8.4% bicarbonate. A 22 gauge 1.5–2.5 inch spinal needle is advanced parallel to the radiographic beam to abut upon the mid-portion near the anterior edge of the superior articular process to gauge depth. The needle is slightly withdrawn and then redirected into the posterior aspect of the foramen 1–2 mm. The position is checked in the AP plane, the needle tip should be slightly beyond the lateral border of the cervical pillar. The needle is then advanced 1–2 mm in the AP plane. If nerve is contacted, the patient typically experiences pain or paresthesia into the scapula or upper extremity. The needle should be slightly withdrawn off the nerve. The needle should not be advanced beyond the mid-sagittal line of the lateral mass. Oblique and lateral views are checked to ensure the needle is in the posterior aspect of the foramen [52]. A 1 cc syringe containing non-ionic contrast (Isovue or Omnipaque) is connected to low volume extension tubing and flushed with contrast. The extension tubing is then connected to the spinal needle hub after first providing a drop of contrast into the spinal needle to flush out any air. The extension tubing minimizes the chance of needle movement with attaching and detaching the various syringes. Furthermore, the tubing keeps the interventionalist’s hand away from the fluoroscopic beam. Contrast 0.5–1.0 cc is then infused under live fluoroscopy carefully evaluating not only for outline of the nerve root but also for any vascular flow. If arterial flow is obtained the procedure is abandoned. If a myelographic pattern is obtained—dural puncture with subarachnoid injection—the procedure is abandoned. If venous flow is obtained, the needle is withdrawn back upon the superior articular process. The needle is then redirected into a different region of the foramen keeping the needle in the posterior half of the foramen—away from the vertebral artery. Multi-planar fluoroscopic imaging of needle placement is performed before infusion of contrast. Contrast should outline the nerve root with epidural flow and no vascular pattern. Digital subtraction imaging has been recommended but not required [77]. Preservative free 1% xylocaine 0.5–1.0 cc is then instilled under live fluoroscopy carefully watching for any vascular flow. After 90 s, the patient is queried about peri-oral numbness, metallic taste, tinnitus, light-headedness, shortness of breath, and agitation. The patient is asked to move the fingers and toes, and pin-prick is tested on the hands and lower legs or feet. If there are no untoward effects, 1.0–1.5 cc dexamethasone may then be infused slowly. Before injecting, imaging is performed to ensure the needle position has not changed.

Most patients do not require any sedation. For those who are very anxious, needle-phobic, vasovagal tendency, poor tolerance to pain or the procedure; intravenous minimal to moderate sedation may be performed. However, the patient still needs to be responsive to voice commands and have their protective mechanisms intact. More specifically, the patient should be able to respond with pain to needle touching nerve root or cord. As previously mentioned cord penetration may be asymptomatic. However, cord injection can be painful and the patient should be awake enough to respond to such an occurrence. The goal of moderate sedation is allow the patient to tolerate the procedure such that the procedure can be performed safely and without endangering the patient.