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Journal of Cardiovascular Translational Research

Erschienen in:

01.02.2014

Monocyte–Platelets Aggregates as Cellular Biomarker of Endothelium-Dependent Coronary Vasomotor Dysfunction in Patients with Coronary Artery Disease

verfasst von: Luigi Di Serafino, Jaydeep Sarma, Karen Dierickx, Ioannis Ntarladimas, Stylianos A. Pyxaras, Leen Delrue, Bernard De Bruyne, William Wijns, Emanuele Barbato, Jozef Bartunek

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 1/2014

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Abstract

Monocyte–platelet aggregates (MPA) are increased in patients with acute coronary syndrome. We investigated whether MPA are associated with the presence of functionally significant coronary stenoses or with coronary arterial endothelial dysfunction. One hundred forty five patients undergoing elective coronary angiography were prospectively enrolled. Functional significance of coronary stenosis was assessed by fractional flow reserve (FFR). Thirty randomly selected patients underwent pacing protocol to evaluate Coronary endothelium-dependent vasomotor function (CVF). Whole blood was drawn to evaluate MPA. In patients with FFR ≤ 0.8 (FFR_pos, n = 75), MPA did not significantly differ from FFR >0.8 patients (FFR_neg, n = 70) (38.1 % [25.7–56.6] vs 34.0 % [20.5–49.9], p = 0.08). CVF was similar in FFR_pos and FFR_neg patients (percent vessel diameter change, %VDC = 7.19 % [6.01–10.9] vs 8.0 % [0.81–9.80], p = 0.78). Yet, patients with abnormal CVF showed higher MPA as compared to patients with preserved CVF (28.3 % [28.8–53.4] vs 20.5 % [17.0–32.9], p = 0.01). Moreover, MPA was inversely correlated with %VDC (R ² = 0.26, p < 0.01). MPA levels are significantly higher in patients with abnormal coronary vasomotor function regardless of the presence of functionally significant coronary stenosis.

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Titel: Monocyte–Platelets Aggregates as Cellular Biomarker of Endothelium-Dependent Coronary Vasomotor Dysfunction in Patients with Coronary Artery Disease
verfasst von: Luigi Di Serafino
Jaydeep Sarma
Karen Dierickx
Ioannis Ntarladimas
Stylianos A. Pyxaras
Leen Delrue
Bernard De Bruyne
William Wijns
Emanuele Barbato
Jozef Bartunek
Publikationsdatum: 01.02.2014
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 1/2014
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-013-9520-x

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