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Erschienen in: Indian Journal of Hematology and Blood Transfusion 2/2014

01.06.2014 | Review Article

Hydroxyurea in Sickle Cell Disease: Drug Review

verfasst von: Rohit Kumar Agrawal, Rakesh Kantilal Patel, Varsha shah, Lalit Nainiwal, Bhadra Trivedi

Erschienen in: Indian Journal of Hematology and Blood Transfusion | Ausgabe 2/2014

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Abstract

Hydroxyurea, a myelosuppressive agent, is the only effective drug proven to reduce the frequency of painful episodes. It raises the level of HbF and the haemoglobin level. It usually decreases the rate of painful episodes by 50 %. It was first tested in sickle cell disease in 1984. It also decreases the rate of ACS episodes and blood transfusions by ~50 % in adults. It was developed as an anticancer drug and has been used to treat myeloproliferative syndromes-leukemia, melanoma, and ovarian cancer. It was approved for use by FDA in adults. Side effects includes neutropenia, bone marrow suppression, elevation of hepatic enzymes, anorexia, nausea, vomiting and infertility.
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Metadaten
Titel
Hydroxyurea in Sickle Cell Disease: Drug Review
verfasst von
Rohit Kumar Agrawal
Rakesh Kantilal Patel
Varsha shah
Lalit Nainiwal
Bhadra Trivedi
Publikationsdatum
01.06.2014
Verlag
Springer India
Erschienen in
Indian Journal of Hematology and Blood Transfusion / Ausgabe 2/2014
Print ISSN: 0971-4502
Elektronische ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-013-0261-4

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