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Neurotoxicity Research

Erschienen in:

01.05.2011

Disruption of the CaMKII/CREB Signaling is Associated with Zinc Deficiency-Induced Learning and Memory Impairments

verfasst von: Hui-Ling Gao, He Xu, Na Xin, Wei Zheng, Zhi-Hong Chi, Zhan-You Wang

Erschienen in: Neurotoxicity Research | Ausgabe 4/2011

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Abstract

Many studies have shown that zinc deficiency not only retards growth, but also affects several brain functions, including learning and memory. However, the underlying mechanism of impaired hippocampus-dependent learning and memory under zinc deficiency is poorly understood. In this study, young mice were fed a zinc-deficient diet (0.85 ppm) for 5 weeks. Morris water maze result showed that zinc deficiency results in spatial learning impairment. We then examined whether zinc depletion-induced learning and memory defects are associated with changes in signaling molecules essential for the expression of long-term potentiation. Immunoblot results showed that the protein levels of calmodulin (CaM), phosphorylated CaM-dependent protein kinase II (CaMKII), and phosphorylated cAMP-responsive element binding protein (CREB) were significantly reduced, whereas the total protein levels of CaMKII and CREB did not change in the zinc-deficient hippocampus. Thus, we provide a previously unrecognized mechanism whereby zinc deficiency impairs hippocampal learning and memory, at least in part, through disruption of the CaM/CaMKII/CREB signaling pathway.

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Titel: Disruption of the CaMKII/CREB Signaling is Associated with Zinc Deficiency-Induced Learning and Memory Impairments
verfasst von: Hui-Ling Gao
He Xu
Na Xin
Wei Zheng
Zhi-Hong Chi
Zhan-You Wang
Publikationsdatum: 01.05.2011
Verlag: Springer-Verlag
Erschienen in: Neurotoxicity Research / Ausgabe 4/2011
Print ISSN: 1029-8428
Elektronische ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-010-9206-y

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