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Tumor Biology

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01.10.2013 | Research Article

The associations between the polymorphisms of the ER-α gene and the risk of uterine leiomyoma (ULM)

verfasst von: Yi Feng, Xiaojuan Lin, Shengtao Zhou, Ning Xu, Tao Yi, Xia Zhao

Erschienen in: Tumor Biology | Ausgabe 5/2013

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Abstract

The ER-α gene polymorphisms have been reported to be associated with uterine leiomyoma (ULM) risk. The purpose of the present study was to perform a meta-analysis to explore the polymorphisms in the ER-α gene and the risk of ULM. A comprehensive search for relevant articles was conducted in MEDLINE (Ovid), PubMed, Embase, Springer, EBSCO, Web of Science, CNKI, Wanfang, Weipu, and Google Scholar. A total of nine articles were identified. Among the nine articles, 11 cohorts reported the PvuII polymorphism and six reported the XbaI polymorphism. The strength of the relationships between the polymorphisms in ER-α (PvuII and XbaI) and the risk of ULM was assessed by odds ratios (ORs). The studies provided overall OR estimates for PvuII and XbaI, leading to a pooled OR of 1.41 (PP+Pp vs. pp: OR = 1.41, 95 % confidence interval (95 %CI) = 1.02–1.96, P = 0.04), 1.13 (XX+Xx vs. xx: OR = 1.13, 95 %CI = 0.91–1.41, P = 0.25), respectively. The PvuII polymorphism in the ER-α gene may be a risk factor for ULM. Future studies are needed to validate our conclusions.

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Titel: The associations between the polymorphisms of the ER-α gene and the risk of uterine leiomyoma (ULM)
verfasst von: Yi Feng
Xiaojuan Lin
Shengtao Zhou
Ning Xu
Tao Yi
Xia Zhao
Publikationsdatum: 01.10.2013
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 5/2013
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-013-0874-0

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The associations between the polymorphisms of the ER-α gene and the risk of uterine leiomyoma (ULM)

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