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Tumor Biology

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01.11.2014 | Research Article

Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case–control studies

verfasst von: Yan-Zhong Feng, Yi-Ling Liu, Xiao-Feng He, Wu Wei, Xu-Liang Shen, Dao-Lin Xie

Erschienen in: Tumor Biology | Ausgabe 11/2014

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Abstract

The Arg194Trp polymorphism in the X-ray cross-complementing group 1 (XRCC1) had been implicated in cancer susceptibility. The previous published data on the association between XRCC1 Arg194Trp polymorphism and cancer risk remained controversial. Hence, we performed a meta-analysis to investigate the association between cancer susceptibility and XRCC1 Arg194Trp (59,227 cases and 81,587 controls from 201 studies) polymorphism in different inheritance models. We used odds ratios with 95 % confidence intervals to assess the strength of the association. Overall, significantly increased cancer risk was found (recessive model: (odds ration [OR] = 1.18, 95 % confidence interval [CI] = 1.09–1.27; homozygous model: OR = 1.21, 95 % CI = 1.10–1.33; additive model: OR = 1.05, 95 % CI = 1.01–1.09) when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, significantly increased glioma risk was found among Asians, significantly decreased lung cancer risk was found among Caucasians, and significant increased breast cancer risk was found among hospital-based studies. In summary, this meta-analysis suggests that Arg194Trp polymorphism may be associated with increased breast cancer risk, Arg194Trp polymorphism is associated with increased glioma risk among Asians, and Arg194Trp polymorphism is associated with decreased lung cancer risk among Caucasians. In addition, our work also points out the importance of new studies for Arg194Trp association in some cancer types, such as gastric, pancreatic, prostate, and nasopharyngeal cancers, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the XRCC1 Arg194Trp polymorphism in cancer development (I ² > 75 %).

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Wood RD, Mitchell M, Sgouros J, Lindahl T. Human DNA repair genes. Science. 2001;291:1284–9.PubMed

Yu Z, Chen J, Ford BN, Brackley ME, Glickman BW. Human DNA repair systems: an overview. Environ Mol Mutagen. 1999;33:3–20.PubMed

Thacker J, Zdzienicka MZ. The mammalian XRCC genes: their roles in DNA repair and genetic stability. DNA Repair (Amst). 2003;2:655–72.

Vidal AE, Boiteux S, Hickson AD, Radicella JP. XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions. EMBO J. 2001;20:6530–9.PubMedCentralPubMed

Lu AL, Li XH, Gu YS, Wright PM, Chang DY. Repair of oxidative DNA damage–mechanisms and functions. Cell Biochem Biophys. 2001;35:141–70.PubMed

Kubota Y, Nash RA, Klungland A, Schär P, Barnes DE, Lindahl T. Resconstitution of DNA base excision repair with purified human proteins: Interaction between DNA polymerase beta and the XRCC1 protein. EMBO J. 1996;15:6662–70.PubMedCentralPubMed

Shen MR, Jones IM, Mohrenweiser H. No conservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res. 1998;58:604–8.PubMed

Duell EJ, Millikan RC, Pittman GS, Winkel S, Lunn RM, Tse CK, et al. Polymorphisms in the DNA repair gene XRCC1 and breast cancer. Cancer Epidemiol Biomarkers Prev. 2001;10:217–22.PubMed

Kim SU, Park SK, Yoo KY, Yoon KS, Choi JY, Seo JS, et al. XRCC1 genetic polymorphism and breast cancer risk. Pharmacogenetics. 2002;12:335–8.PubMed

10.

Smith TR, Levine EA, Perrier ND, Miller MS, Freimanis RI, Lohman K, et al. DNA-repair genetic polymorphisms and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2003;12:1200–4.PubMed

11.

Moullan N, Cox DG, Angèle S, Romestaing P, Gérard JP, Hall J. Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy. Cancer Epidemiol Biomarkers Prev. 2003;12:1168–74.PubMed

12.

Smith TR, Miller MS, Lohman K, Lange EM, Case LD, Mohrenweiser HW, et al. Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer. Cancer Lett. 2003;190:183–90.PubMed

13.

Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, et al. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Res. 2003;63:8536–41.PubMed

14.

Deligezer U, Dalay N. Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients. Exp Mol Med. 2004;36:572–5.PubMed

15.

Patel AV, Calle EE, Pavluck AL, Feigelson HS, Thun MJ, Rodriguez C. A prospective study of XRCC1 (X-ray cross-complementing group 1) polymorphisms and breast cancer risk. Breast Cancer Res. 2005;7:R1168–73.PubMedCentralPubMed

16.

Chacko P, Rajan B, Joseph T, Mathew BS, Pillai MR. Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer. Breast Cancer Res Treat. 2005;89:15–21.PubMed

17.

Shen J, Gammon MD, Terry MB, Wang L, Wang Q, Zhang F, et al. Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2005;14:336–42.PubMed

18.

Brewster AM, Jorgensen TJ, Ruczinski I, Huang HY, Hoffman S, Thuita L, et al. Polymorphisms of the DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp): relationship to breast cancer risk and familial predisposition to breast cancer. Breast Cancer Res Treat. 2006;95:73–80.PubMed

19.

Zhang Y, Newcomb PA, Egan KM, Titus-Ernstoff L, Chanock S, Welch R, et al. Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2006;15:353–8.PubMed

20.

Pachkowski BF, Winkel S, Kubota Y, Swenberg JA, Millikan RC, Nakamura J. XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking. Cancer Res. 2006;66:2860–8.PubMed

21.

Jin MJ, Chen K, Zhang SS, Zhang YJ, Ren YJ, Xu H, et al. Association of single nucleotide polymorphisms and haplotypes in DNA repair gene XRCC1 with susceptibility of breast cancer. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006;35:370–6.PubMed

22.

Thyagarajan B, Anderson KE, Folsom AR, Jacobs Jr DR, Lynch CF, Bargaje A, et al. No association between XRCC1 and XRCC3 gene polymorphisms and breast cancer risk: Iowa Women's Health Study. Cancer Detect Prev. 2006;30:313–21.PubMed

23.

Silva SN, Moita R, Azevedo AP, Gouveia R, Manita I, Pina JE, et al. Menopausal age and XRCC1 gene polymorphisms: role in breast cancer risk. Cancer Detect Prev. 2007;31:303–9.PubMed

24.

Sangrajrang S, Schmezer P, Burkholder I, Waas P, Boffetta P, Brennan P, et al. Polymorphisms in three base excision repair genes and breast cancer risk in Thai women. Breast Cancer Res Treat. 2008;111:279–88.PubMed

25.

Loizidou MA, Michael T, Neuhausen SL, Newbold RF, Marcou Y, Kakouri E, et al. Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus. Breast Cancer Res Treat. 2008;112:575–9.PubMed

26.

Smith TR, Levine EA, Freimanis RI, Akman SA, Allen GO, Hoang KN, et al. Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk. Carcinogenesis. 2008;29:2132–8.PubMedCentralPubMed

27.

Mitra AK, Singh N, Singh A, Garg VK, Agarwal A, Sharma M, et al. Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case–control study in North Indian women. Oncol Res. 2008;17:127–35.PubMed

28.

Sterpone S, Mastellone V, Padua L, Novelli F, Patrono C, Cornetta T, et al. Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women. J Cancer Res Clin Oncol. 2010;136:631–6.PubMed

29.

Ming-Shiean H, Yu JC, Wang HW, Chen ST, Hsiung CN, Ding SL, et al. Synergistic effects of polymorphisms in DNA repair genes and endogenous estrogen exposure on female breast cancer risk. Ann Surg Oncol. 2010;17:760–71.PubMed

30.

Liu L, Yuan P, Liu L, Wu C, Zhang X, Guo H, et al. A functional -77 T > C polymorphism in XRCC1 is associated with risk of breast cancer. Breast Cancer Res Treat. 2011;125:479–87.PubMed

31.

Zipprich J, Terry MB, Brandt-Rauf P, Freyer GA, Liao Y, Agrawal M, et al. XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: A family-based case–control study. J Carcinog. 2010;9:4.PubMedCentralPubMed

32.

Qian Y, Zhang JP, Dong J, Wang FR, Lin YD, Xu M, et al. Relationship between polymorphisms of X-ray repair cross-complementing group 1 gene Arg194Trp, Arg399Gln and susceptibility of breast cancer. Zhonghua Yu Fang Yi Xue Za Zhi. 2010;44:242–6.PubMed

33.

Sobczuk A, Romanowicz-Makowska H, Fiks T, Baszczyński J, Smolarz B. XRCC1 and XRCC3 DNA repair gene polymorphisms in breast cancer women from the Lodz region of Poland. Pol J Pathol. 2009;60:76–80.PubMed

34.

Forsti A, Angelini S, Festa F, Sanyal S, Zhang Z, Grzybowska EB, et al. Single nucleotide polymorphisms in breast cancer. Oncol Rep. 2004;11:917–22.PubMed

35.

Ratnasinghe D, Yao SX, Tangrea JA, Qiao YL, Andersen MR, Barrett MJ, et al. Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2010;10:119–23.

36.

David-Beabes GL, London SJ. Genetic polymorphism of XRCC1 and lung cancer risk among African-Americans and Caucasians. Lung Cancer. 2001;34:333–9.PubMed

37.

Chen S, Tang D, Xue K, Xu L, Ma G, Hsu Y, et al. DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population. Carcinogenesis. 2002;23:1321–5.PubMed

38.

Hung RJ, Brennan P, Canzian F, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, et al. Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study. J Natl Cancer Inst. 2005;97:567–76.PubMed

39.

Schneider J, Classen V, Bernges U, Philipp M. XRCC1 polymorphism and lung cancer risk in relation to tobacco smoking. Int J Mol Med. 2005;16:709–16.PubMed

40.

Shen M, Berndt SI, Rothman N, Mumford JL, He X, Yeager M, et al. Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China. Anticancer Res. 2005;25:537–42.PubMed

41.

Chan EC, Lam SY, Fu KH, Kwong YL. Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes. Cancer Genet Cytogenet. 2005;162:10–20.PubMed

42.

Hu Z, Ma H, Lu D, Zhou J, Chen Y, Xu L, et al. A promoter polymorphism (–77 T > C) of DNA repair gene XRCC1 is associated with risk of lung cancer in relation to tobacco smoking. Pharmacogenet Genomics. 2005;15:457–63.PubMed

43.

Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, et al. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis. 2006;27:560–7.PubMed

44.

Matullo G, Dunning AM, Guarrera S, Baynes C, Polidoro S, Garte S, et al. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. Carcinogenesis. 2006;27:997–1007.PubMed

45.

Hao B, Miao X, Li Y, Zhang X, Sun T, Liang G, et al. A novel T–77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene. 2006;25:3613–20.PubMed

46.

Landi S, Gemignani F, Canzian F, Gaborieau V, Barale R, Landi D, et al. DNA repair and cell cycle control genes and the risk of young-onset lung cancer. Cancer Res. 2006;66:11062–9.PubMed

47.

De Ruyck K, Szaumkessel M, De Rudder I, Dehoorne A, Vral A, Claes K, et al. Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. Mutat Res. 2007;631:101–10.PubMed

48.

Pachouri SS, Sobti RC, Kaur P, Singh J. Contrasting impact of DNA repair gene XRCC1 polymorphisms Arg399Gln and Arg194Trp on the risk of lung cancer in the north-Indian population. DNA Cell Biol. 2007;26:186–91.PubMed

49.

Yin J, Vogel U, Ma Y, Qi R, Sun Z, Wang H. The DNA repair gene XRCC1 and genetic susceptibility of lung cancer in a northeastern Chinese population. Lung Cancer. 2007;56:153–60.PubMed

50.

Improta G, Sgambato A, Bianchino G, Zupa A, Grieco V, La Torre G, et al. Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case–control study in a Southern Italian population. Anticancer Res. 2008;28:2941–6.PubMed

51.

Li M, Yin Z, Guan P, Li X, Cui Z, Zhang J, et al. XRCC1 polymorphisms, cooking oil fume and lung cancer in Chinese women nonsmokers. Lung Cancer. 2008;62:145–51.PubMed

52.

Yin J, Vogel U, Ma Y, Qi R, Wang H. Association of DNA repair gene XRCC1 and lung cancer susceptibility among nonsmoking Chinese women. Cancer Genet Cytogenet. 2009;188:26–31.PubMed

53.

Tanaka Y, Maniwa Y, Bermudez VP, Doi T, Nishio W, Ohbayashi C, et al. Nonsynonymous single nucleotide polymorphisms in DNA damage repair pathways and lung cancer risk. Cancer. 2010;116:896–902.PubMed

54.

Janik J, Swoboda M, Janowska B, Cieśla JM, Gackowski D, Kowalewski J, et al. 8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes. Mutat Res. 2011;709–710:21–31.PubMed

55.

Sliwinski T, Krupa R, Wisniewska-Jarosinska M, Lech J, Morawiec Z, Chojnacki J, et al. No association between the Arg194Trp and Arg399Gln polymorphisms of the XRCC1 gene and colorectal cancer risk and progression in a Polish population. Exp Oncol. 2008;30:253–4.PubMed

56.

Skjelbred CF, Saebø M, Wallin H, Nexø BA, Hagen PC, Lothe IM, et al. Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case–control study. BMC Cancer. 2006;6:67.PubMedCentralPubMed

57.

Narter KF, Ergen A, Agaçhan B, Görmüs U, Timirci O, Isbir T. Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1). Anticancer Res. 2009;29:1389–93.PubMed

58.

Sak SC, Barrett JH, Paul AB, Bishop DT, Kiltie AE. DNA repair gene XRCC1 polymorphisms and bladder cancer risk. BMC Genet. 2007;8:13.PubMedCentralPubMed

59.

Matullo G, Guarrera S, Sacerdote C, Polidoro S, Davico L, Gamberini S, et al. Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case–control study. Cancer Epidemiol Biomarkers Prev. 2005;14:2569–78.PubMed

60.

Figueroa JD, Malats N, Real FX, Silverman D, Kogevinas M, Chanock S, et al. Genetic variation in the base excision repair pathway and bladder cancer risk. Hum Genet. 2007;121:233–42.PubMed

61.

Wu X, Gu J, Grossman HB, Amos CI, Etzel C, Huang M, et al. Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. Am J Hum Genet. 2006;78:464–79.PubMedCentralPubMed

62.

Stern MC, Umbach DM, van Gils CH, Lunn RM, Taylor JA. DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2001;10:125–31.PubMed

63.

Andrew AS, Nelson HH, Kelsey KT, Moore JH, Meng AC, Casella DP, et al. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis. 2006;27:1030–7.PubMed

64.

Wang M, Qin C, Zhu J, Yuan L, Fu G, Zhang Z, et al. Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer. DNA Cell Biol. 2010;29:303–11.PubMed

65.

Andrew AS, Karagas MR, Nelson HH, Guarrera S, Polidoro S, Gamberini S, et al. DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy. Hum Hered. 2008;65:105–18.PubMed

66.

Winsey SL, Haldar NA, Marsh HP, Bunce M, Marshall SE, Harris AL, et al. A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. Cancer Res. 2000;60:5612–6.PubMed

67.

Kang SY, Lee KG, Lee W, Shim JY, Ji SI, Chung KW, et al. Polymorphisms in the DNA repair gene XRCC1 associated with basal cell carcinoma and squamous cell carcinoma of the skin in a Korean population. Cancer Sci. 2007;98:716–20.PubMed

68.

Demokan S, Demir D, Suoglu Y, Kiyak E, Akar U, Dalay N. Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer. Pathol Oncol Res. 2005;11:22–5.PubMed

69.

Kietthubthew S, Sriplung H, Au WW, Ishida T. Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand. Int J Hyg Environ Health. 2006;209:21–9.PubMed

70.

Cao Y, Miao XP, Huang MY, Deng L, Hu LF, Ernberg I, et al. Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population. BMC Cancer. 2006;6:167.PubMedCentralPubMed

71.

Kowalski M, Przybylowska K, Rusin P, Olszewski J, Morawiec-Sztandera A, Bielecka-Kowalska A, et al. Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck. J Exp Clin Cancer Res. 2009;28:37.PubMedCentralPubMed

72.

Chiang FY, Wu CW, Hsiao PJ, Kuo WR, Lee KW, Lin JC, et al. Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma. Clin Cancer Res. 2008;14:5919–24.PubMed

73.

Varzim G, Monteiro E, Silva RA, Fernandes J, Lopes C. CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx. Eur J Cancer Prev. 2003;12:495–9.PubMed

74.

Tae K, Lee HS, Park BJ, Park CW, Kim KR, Cho HY, et al. Association of DNA repair gene XRCC1 polymorphisms with head and neck cancer in Korean population. Int J Cancer. 2004;111:805–8.PubMed

75.

Ruwali M, Khan AJ, Shah PP, Singh AP, Pant MC, Parmar D. Cytochrome P450 2E1 and head and neck cancer: interaction with genetic and environmental risk factors. Environ Mol Mutagen. 2009;50:473–82.PubMed

76.

Majumder M, Sikdar N, Ghosh S, Roy B. Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators. Int J Cancer. 2007;120:2148–56.PubMed

77.

Applebaum KM, McClean MD, Nelson HH, Marsit CJ, Christensen BC, Kelsey KT. Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma. Int J Cancer. 2009;124:2690–6.PubMedCentralPubMed

78.

Majumder M, Sikdar N, Paul RR, Roy B. Increased risk of oral leukoplakia and cancer among mixed tobacco users carrying XRCC1 variant haplotypes and cancer among smokers carrying two risk genotypes: one on each of two loci, GSTM3 and XRCC1 (Codon 280). Cancer Epidemiol Biomarkers Prev. 2005;14:2106–12.PubMed

79.

Sturgis EM, Castillo EJ, Li L, Zheng R, Eicher SA, Clayman GL, et al. Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck. Carcinogenesis. 1999;20:2125–9.PubMed

80.

Yang ZH, Du B, Wei YS, Zhang JH, Zhou B, Liang WB, et al. Genetic polymorphisms of the DNA repair gene and risk of nasopharyngeal carcinoma. DNA Cell Biol. 2007;26:491–6.PubMed

81.

Yen CY, Liu SY, Chen CH, Tseng HF, Chuang LY, Yang CH, et al. Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan. J Oral Pathol Med. 2008;37:271–7.PubMed

82.

Olshan AF, Watson MA, Weissler MC, Bell DA. XRCC1 polymorphisms and head and neck cancer. Cancer Lett. 2002;178:181–6.PubMed

83.

Ramachandran S, Ramadas K, Hariharan R, Rejnish Kumar R, Radhakrishna Pillai M. Single nucleotide polymorphisms of DNA repair genes XRCC1 and XPD and its molecular mapping in Indian oral cancer. Oral Oncol. 2006;42:350–62.PubMed

84.

Jin MJ, Chen K, Zhang Y, Zhang W, Liu B, Zhang YJ. Correlations of single nucleotide polymorphisms of DNA repair gene XRCC1 to risk of colorectal cancer. Ai Zheng. 2007;26:274–9.PubMed

85.

Moreno V, Gemignani F, Landi S, Gioia-Patricola L, Chabrier A, Blanco I, et al. Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer. Clin Cancer Res. 2006;12:2101–8.PubMed

86.

87.

Curtin K, Samowitz WS, Wolff RK, Ulrich CM, Caan BJ, Potter JD, et al. Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:3384–8.PubMedCentralPubMed

88.

Hong YC, Lee KH, Kim WC, Choi SK, Woo ZH, Shin SK, et al. Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer. Int J Cancer. 2005;116:428–32.PubMed

89.

Abdel-Rahman SZ, Soliman AS, Bondy ML, Omar S, El-Badawy SA, Khaled HM, et al. Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt. Cancer Lett. 2000;159:79–86.PubMed

90.

Gil J, Ramsey D, Stembalska A, Karpinski P, Pesz KA, Laczmanska I, et al. The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual's susceptibility to sporadic colorectal cancer. Mol Biol Rep. 2012;39:527–34.PubMed

91.

Berndt SI, Huang WY, Fallin MD, Helzlsouer KJ, Platz EA, Weissfeld JL, et al. Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma. Cancer Res. 2007;67:1395–404.PubMed

92.

Stern MC, Siegmund KD, Corral R, Haile RW. XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk. Cancer Epidemiol Biomarkers Prev. 2005;14:609–15.PubMed

93.

Stern MC, Conti DV, Siegmund KD, Corral R, Yuan JM, Koh WP, et al. DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev. 2007;16:2363–72.PubMed

94.

McWilliams RR, Bamlet WR, Cunningham JM, Goode EL, de Andrade M, Boardman LA, et al. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. Cancer Res. 2008;68:4928–35.PubMedCentralPubMed

95.

Jiao L, Bondy ML, Hassan MM, Wolff RA, Evans DB, Abbruzzese JL, et al. Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. Cancer Detect Prev. 2006;30:284–91.PubMed

96.

Xu Z, Hua LX, Qian LX, Yang J, Wang XR, Zhang W, et al. Relationship between XRCC1 Polymorphisms and susceptibility to prostate cancer in men from Han. South China Asian J Androl. 2007;9:331–8.

97.

van Gils CH, Bostick RM, Stern MC, Taylor JA. Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene. Cancer Epidemiol Biomarkers Prev. 2002;11:1279–84.PubMed

98.

Hamano T, Matsui H, Sekine Y, Ohtake N, Nakata S, Suzuki K. Polymorphisms of DNA repair genes, XRCC1 and XRCC3, and susceptibility to familial prostate cancer in a Japanese population. Asian Pac J Clin Oncol. 2008;4:21–6.

99.

Agalliu I, Kwon EM, Salinas CA, Koopmeiners JS, Ostrander EA, Stanford JL. Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. Cancer Causes Control. 2010;21:289–300.PubMedCentralPubMed

100.

Hirata H, Hinoda Y, Tanaka Y, Okayama N, Suehiro Y, Kawamoto K, et al. Polymorphisms of DNA repair genes are risk factors for prostate cancer. Eur J Cancer. 2007;43:231–7.PubMed

101.

Lee JM, Lee YC, Yang SY, Yang PW, Luh SP, Lee CJ, et al. Genetic polymorphisms of XRCC1 and risk of the esophageal cancer. Int J Cancer. 2001;95:240–6.PubMed

102.

Casson AG, Zheng Z, Evans SC, Veugelers PJ, Porter GA, Guernsey DL. Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma. Carcinogenesis. 2005;26:1536–41.PubMed

103.

Xing D, Qi J, Miao X, Lu W, Tan W, Lin D. Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population. Int J Cancer. 2002;100:600–5.PubMed

104.

Hao B, Wang H, Zhou K, Li Y, Chen X, Zhou G, et al. Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. Cancer Res. 2004;64:4378–84.PubMed

105.

Yu HP, Zhang XY, Wang XL, Shi LY, Li YY, Li F, et al. DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk. Cancer Detect Prev. 2004;28:194–9.PubMed

106.

Ratnasinghe LD, Abnet C, Qiao YL, Modali R, Stolzenberg-Solomon R, Dong ZW, et al. Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer. Cancer Lett. 2004;216:157–64.PubMed

107.

Shen H, Xu Y, Qian Y, Yu R, Qin Y, Zhou L, et al. Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population. Int J Cancer. 2000;88:601–6.PubMed

108.

Palli D, Polidoro S, D'Errico M, Saieva C, Guarrera S, Calcagnile AS, et al. Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer. Mutagenesis. 2010;25:569–75.PubMed

109.

Wen YY, Pan XF, Loh M, Tian Z, Yang SJ, Lv SH, et al. ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China. Asian Pac J Cancer Prev. 2012;13:2139–44.PubMed

110.

Duarte MC, Colombo J, Rossit AR, Caetano A, Borim AA, Wornrath D, et al. Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer. World J Gastroenterol. 2005;11:6593–600.PubMed

111.

Yan L, Yanan D, Donglan S, Na W, Rongmiao Z, Zhifeng C. Polymorphisms of XRCC1 gene and risk of gastric cardiac adenocarcinoma. Dis Esophagus. 2009;22:396–401.PubMed

112.

Capellá G, Pera G, Sala N, Agudo A, Rico F, Del Giudicce G, et al. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. Int J Epidemiol. 2008;37:1316–25.PubMed

113.

Shen X, Zhang J, Yan Y, Yang Y, Fu G, Pu Y. Analysis and estimates of the attributable risk for environmental and genetic risk factors in gastric cancer in a Chinese population. J Toxicol Environ Health. 2009;72:759–66.

114.

Lee SG, Kim B, Choi J, Kim C, Lee I, Song K. Genetic polymorphisms of XRCC1 and risk of gastric cancer. Cancer Lett. 2002;187:53–60.PubMed

115.

Ganster C, Neesen J, Zehetmayer S, Jäger U, Esterbauer H, Mannhalter C, et al. DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic lymphocytic leukemia. Genes Chromosome Cancer. 2009;48:760–7.

116.

Huang WY, Gao YT, Rashid A, Sakoda LC, Deng J, Shen MC, et al. Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case–control study in China. Carcinogenesis. 2008;29:100–5.PubMed

117.

Ho T, Li G, Lu J, Zhao C, Wei Q, Sturgis EM. X-ray repair cross-complementing group 1 (XRCC1) single-nucleotide polymorphisms and the risk of salivary gland carcinomas. Cancer. 2007;110:318–25.PubMed

118.

Hirata H, Hinoda Y, Matsuyama H, Tanaka Y, Okayama N, Suehiro Y, et al. Polymorphisms of DNA repair genes are associated with renal cell carcinoma. Biochem Biophys Res Commun. 2006;342:1058–62.PubMed

119.

Kumar A, Pant MC, Singh HS, Khandelwal S. Associated risk of XRCC1 and XPD cross talk and life style factors in progression of head and neck cancer in north Indian population. Mutat Res. 2012;729:24–34.PubMed

120.

Liu Y, Scheurer ME, El-Zein R, Cao Y, Do KA, Gilbert M, et al. Association and interactions between DNA repair gene polymorphisms and adult glioma. Cancer Epidemiol Biomarkers Prev. 2009;18:204–14.PubMedCentralPubMed

121.

Baris S, Celkan T, Batar B, Guven M, Ozdil M, Ozkan A, et al. Association between genetic polymorphism in DNA repair genes and risk of B-cell lymphoma. Pediatr Hematol Oncol. 2009;26:467–72.PubMed

122.

Csejtei A, Tibold A, Koltai K, Varga Z, Szanyi I, Gobel G, et al. Association between XRCC1 polymorphisms and head and neck cancer in a Hungarian population. Anticancer Res. 2009;29:4169–73.PubMed

123.

Fard-Esfahani P, Fard-Esfahani A, Fayaz S, Ghanbarzadeh B, Saidi P, Mohabati R, et al. Association of Arg194Trp, Arg280His and Arg399Gln polymorphisms in X-ray repair cross-complementing group 1 gene and risk of differentiated thyroid carcinoma in Iran. Iran Biomed J. 2011;15:73–8.PubMedCentralPubMed

124.

Yuan T, Deng S, Chen M, Chen W, Lu W, Huang H, et al. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Cancer Epidemiol. 2011;35:170–4.PubMed

125.

Ho T, Li G, Lu J, Zhao C, Wei Q, Sturgis EM. Association of XRCC1 polymorphisms and risk of differentiated thyroid carcinoma: a case–control analysis. Thyroid. 2009;19:129–35.PubMed

126.

Mittal RD, Mandal RK, Gangwar R. Base excision repair pathway genes polymorphism in prostate and bladder cancer risk in North Indian population. Mech Ageing Dev. 2012;133:127–32.PubMed

127.

Fontana L, Bosviel R, Delort L, Guy L, Chalabi N, Kwiatkowski F, et al. DNA repair gene ERCC2, XPC, XRCC1, XRCC3 polymorphisms and associations with bladder cancer risk in a French cohort. Anticancer Res. 2008;28:1853–6.PubMed

128.

Gugatschka M, Dehchamani D, Wascher TC, Friedrich G, Renner W. DNA repair gene ERCC2 polymorphisms and risk of squamous cell carcinoma of the head and neck. Exp Mol Pathol. 2011;91:331–4.PubMed

129.

Batar B, Güven M, Bariş S, Celkan T, Yildiz I. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia. Leuk Res. 2009;33:759–63.PubMed

130.

Joseph T, Kusumakumary P, Chacko P, Abraham A, Pillai MR. DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia. Cancer Lett. 2005;217:17–24.PubMed

131.

Liu J, Song B, Wang Z, Song X, Shi Y, Zheng J, et al. DNA repair gene XRCC1 polymorphisms and non-Hodgkin lymphoma risk in a Chinese population. Cancer Genet Cytogenet. 2009;191:67–72.PubMed

132.

Kim IS, Kim DC, Kim HG, Eom HS, Kong SY, Shin HJ, et al. DNA repair gene XRCC1 polymorphisms and haplotypes in diffuse large B-cell lymphoma in a Korean population. Cancer Genet Cytogenet. 2010;196:31–7.PubMed

133.

Pakakasama S, Sirirat T, Kanchanachumpol S, Udomsubpayakul U, Mahasirimongkol S, Kitpoka P, et al. Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007;48:16–20.PubMed

134.

Yin G, Morita M, Ohnaka K, Toyomura K, Hamajima N, Mizoue T, et al. Genetic polymorphisms of XRCC1, alcohol consumption, and the risk of colorectal cancer in Japan. J Epidemiol. 2012;22:64–71.PubMedCentralPubMed

135.

Settheetham-Ishida W, Yuenyao P, Natphopsuk S, Settheetham D, Ishida T. Genetic risk of DNA repair gene polymorphisms (XRCC1 and XRCC3) for high risk human papillomavirus negative cervical cancer in Northeast Thailand. Asian Pac J Cance Prev. 2011;12:963–6.

136.

Han J, Hankinson SE, Colditz GA, Hunter DJ. Genetic variation in XRCC1, sun exposure, and risk of skin cancer. Br J Cancer. 2004;91:1604–9.PubMedCentralPubMed

137.

Harth V, Schafer M, Abel J, Maintz L, Neuhaus T, Besuden M, et al. Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair. J Toxicol Environ Health A. 2008;71:887–97.PubMed

138.

Monroy CM, Cortes AC, Lopez M, Rourke E, Etzel CJ, Younes A, et al. Hodgkin lymphoma risk: role of genetic polymorphisms and gene–gene interactions in DNA repair pathways. Mol Carcinog. 2011;50:825–34.PubMedCentralPubMed

139.

Canalle R, Silveira VS, Scrideli CA, Queiroz RG, Lopes LF, Tone LG. Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia. Leuk Lymphoma. 2011;52:1118–26.PubMed

140.

Gonçalves FT, Francisco G, de Souza SP, Luiz OC, Festa-Neto C, Sanches JA, et al. European ancestry and polymorphisms in DNA repair genes modify the risk of melanoma: a case–control study in a high UV index region in Brazil. J Dermatol Sci. 2011;64:59–66.PubMed

141.

Yu H, Fu C, Wang J, Xue H, Xu B. Interaction between XRCC1 polymorphisms and intake of long-term stored rice in the risk of esophageal squamous cell carcinoma: a case-control study. Biomed Environ Sci. 2011;24:268–74.PubMed

142.

Duman N, Aktan M, Ozturk S, Palanduz S, Cakiris A, Ustek D, et al. Investigation of Arg399Gln and Arg194Trp polymorphisms of the XRCC1 (X-ray cross-complementing group 1) gene and its correlation to sister chromatid exchange frequency in patients with chronic lymphocytic leukemia. Genet Test Mol Biomark. 2012;16:287–91.

143.

Muñiz-Mendoza R, Ayala-Madrigal ML, Partida-Pérez M, Peregrina-Sandoval J, Leal-Ugarte E, Macías-Gómez N, et al. MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer. Genet Mol Res. 2012;11:2315–20.PubMed

144.

Gsur A, Bernhart K, Baierl A, Feik E, Führlinger G, Hofer P, et al. No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk. Cancer Epidemiol. 2011;35:e38–41.PubMed

145.

Kiran M, Saxena R, Chawla YK, Kaur J. Polymorphism of DNA repair gene XRCC1 and hepatitis-related hepatocellular carcinoma risk in Indian population. Mol Cell Biochem. 2009;327:7–13.PubMed

146.

Santos LS, Branco SC, Silva SN, Azevedo AP, Gil OM, Manita I, et al. Polymorphisms in base excision repair genes and thyroid cancer risk. Oncol Rep. 2012;28:1859–68.PubMed

147.

Brevik A, Joshi AD, Corral R, Onland-Moret NC, Siegmund KD, Le Marchand L, et al. Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. Cancer Epidemiol Biomarkers Prev. 2010;19:3167–73.PubMedCentralPubMed

148.

Dianzani I, Gibello L, Biava A, Giordano M, Bertolotti M, Betti M, et al. Polymorphisms in DNA repair genes as risk factors for asbestos-related malignant mesothelioma in a general population study. Mutat Res. 2006;599:124–34.PubMed

149.

Shen M, Purdue MP, Kricker A, Lan Q, Grulich AE, Vajdic CM, et al. Polymorphisms in DNA repair genes and risk of non-Hodgkin's lymphoma in New South Wales. Aust Haematol. 2007;92:1180–5.

150.

Zhou LQ, Ma Z, Shi XF, Yin XL, Huang KX, Jiu ZS, et al. Polymorphisms of DNA repair gene XRCC1 and risk of glioma: a case–control study in Southern China. Asian Pac J Cancer Prev. 2011;12:2547–50.PubMed

151.

Sobczuk A, Poplawski T, Blasiak J. Polymorphisms of DNA repair genes in endometrial cancer. Pathol Oncol Res. 2012;18:1015–20.PubMedCentralPubMed

152.

Bianchino G, Cittadini A, Grieco V, Traficante A, Zupa A, Improta G, et al. Polymorphisms of the CYP1A1, CYP2E1 and XRCC1 genes and cancer risk in a Southern Italian population: a case–control study. Anticancer Res. 2011;31:1359–65.PubMed

153.

Wang L, Lin DX, Lu XH, Miao XP, Li H. Polymorphisms of the DNA repair genes XRCC1 and XPC: relationship to pancreatic cancer risk. Wei Sheng Yan Jiu. 2006;35:534–6.PubMed

154.

Srivastava A, Srivastava K, Pandey SN, Choudhuri G, Mittal B. Single-nucleotide polymorphisms of DNA repair genes OGG1 and XRCC1: association with gallbladder cancer in North Indian population. Ann Surg Oncol. 2009;16:1695–703.PubMed

155.

Hsu LI, Chiu AW, Huan SK, Chen CL, Wang YH, Hsieh FI, et al. SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan. Toxicol Appl Pharmacol. 2008;228:144–55.PubMed

156.

Han X, Xing Q, Li Y, Sun J, Ji H, Huazheng P, et al. Study on the DNA repair gene XRCC1 and XRCC3 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. Hepatogastroenterology. 2012;59:2285–9.PubMed

157.

Rydzanicz M, Wierzbicka M, Gajecka M, Szyfter W, Szyfter K. The impact of genetic factors on the incidence of multiple primary tumors (MPT) of the head and neck. Cancer Lett. 2005;224:263–78.PubMed

158.

Huang J, Ye F, Chen H, Lu W, Xie X. The nonsynonymous single nucleotide polymorphisms of DNA repair gene XRCC1 and susceptibility to the development of cervical carcinoma and high-risk human papillomavirus infection. Int J Gynecol Cancer. 2007;17:668–75.PubMed

159.

Smedby KE, Lindgren CM, Hjalgrim H, Humphreys K, Schöllkopf C, Chang ET, et al. Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma. Cancer Epidemiol Biomarkers Prev. 2006;15:258–65.PubMed

160.

Kiuru A, Lindholm C, Heinävaara S, Ilus T, Jokinen P, Haapasalo H, et al. XRCC1 and XRCC3 variants and risk of glioma and meningioma. J Neurooncol. 2008;88:135–42.PubMed

161.

Chiyomaru K, Nagano T, Nishigori C. XRCC1 Arg194Trp polymorphism, risk of nonmelanoma skin cancer and extramammary Paget's disease in a Japanese population. Arch Dermatol Res. 2012;304:363–70.PubMedCentralPubMed

162.

Mittal RD, Singh R, Manchanda PK, Ahirwar D, Gangwar R, Kesarwani P, et al. XRCC1 codon 399 mutant allele: a risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy. Cancer Biol Ther. 2008;7:645–50.PubMed

163.

Wang N, Wu Y, Zhou X, Wu Y. Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population. Wei Sheng Yan Jiu. 2012;41:251–6.PubMed

164.

Meza-Espinoza JP, Peralta-Leal V, Gutierrez-Angulo M, Macias-Gomez N, Ayala-Madrigal ML, Barros-Nuñez P, et al. XRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemia. Genet Mol Res. 2009;8:1451–8.PubMed

165.

Ryu RA, Tae K, Min HJ, Jeong JH, Cho SH, Lee SH, et al. XRCC1 polymorphisms and risk of papillary thyroid carcinoma in a Korean sample. J Korean Med Sci. 2011;26:991–5.PubMedCentralPubMed

166.

Gao R, Price DK, Dahut WL, Reed E, Figg WD. Genetic polymorphisms in XRCC1 associated with radiation therapy in prostate cancer. Cancer Biol Ther. 2010;10:13–8.PubMedCentralPubMed

167.

Tumer TB, Yilmaz D, Tanrikut C, Sahin G, Ulusoy G, Arinç E. DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia. Leuk Res. 2010;34:1275–81.PubMed

168.

Zhu R, Lu FJ, Zhang ZB, Zhai XW, Liu J, Lu G, et al. Association of genetic polymorphism of XRCC1 with susceptibility to acute childhood leukemia. Wei Sheng Yan Jiu. 2005;34:300–2.PubMed

169.

Barbisan G, Pérez LO, Difranza L, Fernández CJ, Ciancio NE, Golijow CD. XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women. Eur J Gynaecol Oncol. 2011;32:274–9.PubMed

170.

Romanowicz-Makowska H, Smolarz B, Kulig A. Polymorphisms in XRCC1 and ERCC4/XPF DNA repair genes and associations with breast cancer risk in women. Pol Merkur Lekarski. 2007;22:200–3.PubMed

171.

Seedhouse C, Bainton R, Lewis M, Harding A, Russell N, Das-Gupta E. The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia. Blood. 2002;100:3761–6.PubMed

172.

Matullo G, Dunning AM, Guarrera S, Baynes C, Polidoro S, Garte S, et al. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. Carcinogenesis. 2006;27:997–1007.PubMed

173.

Gajecka M, Rydzanicz M, Jaskula-Sztul R, Wierzbicka M, Szyfter W, Szyfter K. Reduced DNA repair capacity in laryngeal cancer subjects. A comparison of phenotypic and genotypic results. Adv Otorhinolaryngol. 2005;62:25–37.PubMed

174.

Laantri N, Jalbout M, Khyatti M, Ayoub WB, Dahmoul S, Ayad M, et al. XRCC1 and hOGG1 genes and risk of nasopharyngeal carcinoma in North African Countries. Mol Carcinog. 2011;50:732–7.PubMed

175.

Mandal RK, Gangwar R, Mandhani A, Mittal RD. DNA repair gene X-ray repair cross-complementing group 1 and xeroderma pigmentosum group D polymorphisms and risk of prostate cancer: a study from North India. DNA Cell Biol. 2010;29:183–90.PubMed

176.

Yin JY, Vogel U, Gerdes LU, Dybdahl M, Bolund L, Nexø BA. Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3: Linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients. Biochem Genet. 2003;41:27–37.PubMed

177.

Farkasova T, Gurska S, Witkovsky V, Gabelova A. Significance of amino acid substitution variants of DNA repair genes in radiosusceptibility of cervical cancer patients; a pilot study. Neoplasma. 2008;55:330–7.PubMed

178.

Chang JS, Wrensch MR, Hansen HM, Sison JD, Aldrich MC, Quesenberry Jr CP, et al. Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans. Carcinogenesis. 2009;30:78–87.PubMedCentralPubMed

179.

Celkan T, Güven M, Batar B, Alhaj S. The diff erence between pre-B cell acute lymphoblastic leukemia and Burkitt lymphoma in relation to DNA damage repair gene polymorphisms in childhood. Leuk Lymphoma. 2008;49:1638–40.PubMed

180.

Custódio AC, Almeida LO, Pinto GR, Santos MJ, Almeida JR, Clara CA, et al. Analysis of the polymorphisms XRCC1Arg194Trp and XRCC1Arg399Gln in gliomas. Genet Mol Res. 2011;10:1120–9.PubMed

181.

Rajaraman P, Melin BS, Wang Z, McKean-Cowdin R, Michaud DS, Wang SS, et al. Genome-wide association study of glioma and meta-analysis. Hum Genet. 2012;131:1877–88.PubMedCentralPubMed

182.

Hu XB, Feng Z, Fan YC, Xiong ZY, Huang QW. Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to glioma. Asian Pac J Cancer Prev. 2011;12:2981–4.PubMed

183.

McKean-Cowdin R, Barnholtz-Sloan J, Inskip PD, Ruder AM, Butler M, Rajaraman P, et al. Associations between polymorphisms in DNA repair genes and glioblastoma. Cancer Epidemiol Biomarkers Prev. 2009;18:1118–26.PubMedCentralPubMed

184.

Wang D, Hu Y, Gong H, Li J, Ren Y, et al. Genetic polymorphisms in the DNA repair gene XRCC1 and susceptibility to glioma in a Han population in northeastern China: a case–control study. Gene. 2012;509:223–7.PubMed

185.

Liu HB, Peng YP, Dou CW, Su XL, Gao NK, Tian FM, et al. Comprehensive study on associations between nine SNPs and glioma risk. Asian Pac J Cancer Prev. 2012;13:4905–8.PubMed

186.

Pardini B, Naccarati A, Novotny J, et al. DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic. Mutat Res. 2008;638:146–53.PubMed

187.

Li Y, Li S, Wu Z, Hu F, Zhu L, Zhao X, et al. Polymorphisms in genes of APE1, PARP1, and XRCC1: risk and prognosis of colorectal cancer in a northeast Chinese population. Med Oncol. 2013;30:505.PubMed

188.

Huang M, Dinney CP, Lin X, Lin J, Grossman HB, Wu X. High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. Cancer Epidemiol Biomarkers Prev. 2007;16:84–91.PubMed

189.

Buch SC, Diergaarde B, Nukui T, Day RS, Siegfried JM, Romkes M, et al. Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer. Mol Carcinog. 2012;51:E11–20.PubMedCentralPubMed

190.

Guo S, Li X, Gao M, Li Y, Song B, Niu W. The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PLoS ONE. 2013;8:e56213.PubMedCentralPubMed

191.

Zhu QX, Bian JC, Shen Q, et al. Genetic polymorphisms in X-ray repair cross-complementing gene 1 and susceptibility to papillary thyroid carcinoma. Zhonghua Liu Xing Bing Xue Za Zhi. 2004;25:702–5.PubMed

192.

Sigurdson AJ, Land CE, Bhatti P, Pineda M, Brenner A, Carr Z, et al. Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan. Radiat Res. 2009;171:77–88.PubMedCentralPubMed

193.

Dos Reis MB, Losi-Guembarovski R, de Souza Fonseca Ribeiro EM, Cavalli IJ, Morita MC, et al. Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients. J Oral Pathol Med. 2013;42:180–5.PubMed

194.

Mahimkar MB, Samant TA, Kannan S, Patil T. Influence of genetic polymorphisms on frequency of micronucleated buccal epithelial cells in leukoplakia patients. Oral Oncol. 2010;46:761–6.PubMed

195.

Annamaneni S, Gorre M, Kagita S, Addepalli K, Digumarti RR, Satti V, et al. Association of XRCC1 gene polymorphisms with chronic myeloid leukemia in the population of Andhra Pradesh, India. Hematology. 2013;18:163–8.PubMed

196.

Banescu C, Duicu C, Trifa AP, Dobreanu M. XRCC1 Arg194Trp and Arg399Gln polymorphisms are significantly associated with shorter survival in acute myeloid leukemia. Leuk Lymphoma. 2014;55:365–70.PubMed

197.

Kim HN, Kim NY, Yu L, Tran HT, Kim YK, Lee IK, et al. Association of GSTT1 polymorphism with acute myeloid leukemia risk is dependent on smoking status. Leuk Lymphoma. 2012;53:681–7.PubMed

198.

Shi JY, Ren ZH, Jiao B, Xiao R, Yun HY, Chen B, et al. Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia. Int J Cancer J Int du Cancer. 2011;128:233–8.

199.

Zhu R, Wu Y, Lu FJ, Wang AH, Tang JY, Zhao JC, et al. Polymorphisms and haplotypes of XRCC1 and APE1 and risk of childhood leukaemia in China: a case-control analysis. Eur J Oncol. 2008;13:187–92.

200.

Luo KQ, Mu SQ, Wu ZX, Shi YN, Peng JC. Polymorphisms in DNA repair genes and risk of glioma and meningioma. Asian Pac J Cancer Prev. 2013;14:449–52.PubMed

201.

Pan XF, Xie Y, Loh M, Yang SJ, Wen YY, Tian Z, et al. Polymorphisms of XRCC1 and ADPRT genes and risk of noncardia gastric cancer in a Chinese population: a case–control study. Asian Pac J Cancer Prev. 2012;13:5637–42.PubMed

202.

Pan WR, Li G, Guan JH. Polymorphisms in DNA repair genes and susceptibility to glioma in a Chinese population. Int J Mol Sci. 2013;14:3314–24.PubMedCentralPubMed

203.

Dai L, Duan F, Wang P, Song C, Wang K, Zhang J. XRCC1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 case–control studies. Mol Biol Rep. 2012;39:9535–47.PubMed

204.

Jiang L, Fang X, Bao Y, Zhou JY, Shen XY, Ding MH, et al. Association between the XRCC1 polymorphisms and glioma risk: a meta-analysis of case–control studies. PLoS ONE. 2013;8:e55597.PubMedCentralPubMed

205.

Wang L, Yin F, Xu X, Hu X, Zhao D. X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and risk of childhood acute lymphoblastic leukemia: a meta-analysis. PLoS ONE. 2012;7:e34897.PubMedCentralPubMed

206.

Davey SG, Egger M. Meta-analyses of randomized controlled trials. Lancet. 1997;350:1182.

207.

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analysis. Br Med J. 2003;327:557–60.

208.

Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. Natl Cancer Inst. 1959;22:719–48.

209.

DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.PubMed

210.

Klug SJ, Ressing M, Koenig J, Abba MC, Agorastos T, Brenna SM, et al. TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies. Lancet Oncol. 2009;10:772–84.PubMed

211.

Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101.PubMed

212.

Egger M, Smith DG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Br Med J. 1997;315:629–34.

213.

Caldecott KW, Aoufouchi S, Johnson P, Shall S. XRCC1 polypeptide interacts with DNA polymerase beta and possiblypoly (ADP-ribose) polymerase, and DNA ligase III is a novelmolecular “nick-sensor” in vitro. Nucleic Acids Res. 1996;24:4387–94.PubMedCentralPubMed

214.

Kubota Y, Nash RA, Klungland A, Schar P, Barnes DE, Lindahl T. Reconstitution of DNA base excision-repair withpurified human proteins: interaction between DNA polymerasebeta and the XRCC1 protein. Eur Mol Biol Org J. 1996;15:6662–70.

215.

Cappelli E, Taylor R, Cevasco M, Abbondandolo A, Caldecott K, Frosina G. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. J Biol Chem. 1997;272:23970–5.PubMed

216.

Chen D, Yu Z, Zhu Z, Lopez CD. E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair. J Biol Chem. 2008;283:15381–9.PubMedCentralPubMed

217.

Tebbs RS, Flannery ML, Meneses JJ, Hartmann A, Tucker JD, Thompson LH, et al. Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Dev Biol. 1999;208:513–29.PubMed

218.

Moore DJ, Taylor RM, Clements P, Caldecott KW. Mutation of a BRCT domain selectively disrupts DNA singlestrand break repair in noncycling Chinese hamster ovary cells. Proc Natl Acad Sci U S A. 2000;97:13649–54.PubMedCentralPubMed

219.

Wang Y, Yang H, Li H, Li L, Wang H, Liu C, et al. Association between X-ray repair cross complementing group 1 codon 399 and 194 polymorphisms and lung cancer risk: a meta-analysis. Cancer Lett. 2009;285:134–40.PubMed

220.

Chen B, Zhou Y, Yang P, Wu XT. Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis. Mol Biol Rep. 2012;39:1305–13.PubMed

221.

Wang B, Wang D, Huang G, Zhang C, Xu DH, Zhou W. XRCC1 polymorphisms and risk of colorectal cancer: a meta-analysis. Int J Colorectal Dis. 2010;25:313–21.PubMed

Titel: Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case–control studies
verfasst von: Yan-Zhong Feng
Yi-Ling Liu
Xiao-Feng He
Wu Wei
Xu-Liang Shen
Dao-Lin Xie
Publikationsdatum: 01.11.2014
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 11/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-2326-x

Springer Medizin

Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case–control studies

Abstract

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Update Onkologie

Springer Medizin

Abstract

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