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01.11.2014 | Research Article

miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151

verfasst von: Ronglin Zhai, Xuefeng Kan, Bo Wang, Hansong Du, Yueping Long, Heshui Wu, Kaixiong Tao, Guobin Wang, Lihong Bao, Fen Li, Wanli Zhang

Erschienen in: Tumor Biology | Ausgabe 11/2014

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Abstract

We aimed to study the post-translational regulation of CD151 by the microRNA miR-152. CD151 is highly expressed in gastric cancer (GC) and has been shown to accelerate GC by enhancing invasion and metastasis; however, its regulation is still unclear. Our results showed decreased expression of miR-152 in GC tissue samples and cell lines. In addition, miR-152 complementation significantly inhibits both the proliferation and motility of GC cells. CD151 was found to be a target of miR-152, and overexpression of CD151 attenuated the suppressive effect of miR-152. Our findings highlight an essential role of miR-152 in the regulation of proliferation and motility of GC cells and suggest a potential application of miR-152 in GC treatment.

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Titel: miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151
verfasst von: Ronglin Zhai
Xuefeng Kan
Bo Wang
Hansong Du
Yueping Long
Heshui Wu
Kaixiong Tao
Guobin Wang
Lihong Bao
Fen Li
Wanli Zhang
Publikationsdatum: 01.11.2014
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 11/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-2471-2

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miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151

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