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CEN Case Reports
Erschienen in: CEN Case Reports 2/2018

01.11.2018 | Case Report

Warfarin-related nephropathy with acute kidney injury in a patient with immunoglobulin A nephropathy

verfasst von: Hiroki Ishii, Keiji Hirai, Katsunori Yanai, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Yoshio Kaku, Taro Hoshino, Honami Mori, Susumu Ookawara, Yoshihiko Ueda, Yoshiyuki Morishita

Erschienen in: CEN Case Reports | Ausgabe 2/2018

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Abstract

A 55-year-old man with Marfan syndrome taking warfarin for anticoagulant therapy after aortic valve replacement developed acute kidney injury (serum creatinine level of 9.01 mg/dL) and gross macrohematuria. Renal biopsy showed red cell casts in the renal tubules, glomerular crescent formation in the glomeruli with immunoglobulin A deposition, and global sclerosis. Based on these findings, the patient was diagnosed with warfarin-related nephropathy with acute kidney injury characterized by immunoglobulin A nephropathy with crescents. The warfarin was withdrawn, and his hematuria and renal function improved without immunosuppressive agents.
Literatur
1.
Volpi A, Ferrario GM, Giordano F, Antiga G, Battini G, Fabbri C, et al. Acute renal failure due to hypersensitivity interstitial nephritis induced by warfarin sodium. Nephron. 1989;52(2):196.CrossRef
2.
Dajani YF. Hematuria in patients on anticoagulants. N Engl J Med. 1977;297(4):222.PubMed
3.
Klinger ME, Tanenbaum B, Elguezabal A. Pseudo-tumors of the kidney secondary to anticoagulant therapy. J Urol. 1971;106(4):507–11.CrossRef
4.
Brodsky SV, Nadasdy T, Rovin BH, Satoskar AA, Nadasdy GM, Wu HM, et al. Warfarin-related nephropathy occurs in patients with and without chronic kidney disease and is associated with an increased mortality rate. Kidney Int. 2011;80(2):182 – 90.CrossRef
5.
Brodsky SV, Satoskar A, Chen J, Nadasdy G, Eagen JW, Hamirani M, et al. Acute kidney injury during warfarin therapy associated with obstructive tubular red blood cell casts: a report of 9 cases. Am J Kidney Dis. 2009;54(6):1121–6.CrossRef
6.
Kincaid-Smith P, Bennett WM, Dowling JP, Ryan GB. Acute renal failure and tubular necrosis associated with hematuria due to glomerulonephritis. Clin Nephrol. 1983;19(4):206–10.PubMed
7.
Heyman SN, Brezis M. Acute renal failure in glomerular bleeding: a puzzling phenomenon. Nephrol Dial Transplant. 1995;10(5):591–3.PubMed
8.
Brodsky SV, Collins M, Park E, Rovin BH, Satoskar AA, Nadasdy G, et al. Warfarin therapy that results in an international normalization ratio above the therapeutic range is associated with accelerated progression of chronic kidney disease. Nephron Clin Pract. 2010;115(2):c142-6.CrossRef
9.
Brodsky SV. Anticoagulants and acute kidney injury: clinical and pathology considerations. Kidney Res Clin Pract. 2014;33(4):174 – 80.CrossRef
10.
Martin Cleary C, Moreno JA, Fernandez B, Ortiz A, Parra EG, Gracia C, et al. Glomerular haematuria, renal interstitial haemorrhage and acute kidney injury. Nephrol Dial Transplant. 2010;25(12):4103–6.CrossRef
11.
Abt AB, Carroll LE, Mohler JH. Thin basement membrane disease and acute renal failure secondary to gross hematuria and tubular necrosis. Am J Kidney Dis. 2000;35(3):533–6.CrossRef
12.
Santos C, Gomes AM, Ventura A, Almeida C, Seabra J. An unusual cause of glomerular hematuria and acute kidney injury in a chronic kidney disease patient during warfarin therapy. Nefrologia. 2013;33(3):400–3.PubMed
13.
Larpparisuth N, Cheunsuchon B, Chawanasuntorapoj R, Vasuvattakul S, Vareesangthip K. Warfarin related nephropathy: the first case report in Thailand. J Med Assoc Thai. 2015;98(2):212–6.PubMed
14.
Ng CY, Tan CS, Chin CT, Lim SL, Zhu L, Woo KT, et al. Warfarin related nephropathy: a case report and review of the literature. BMC Nephrol. 2016;17:15.CrossRef
15.
Maeda A, Gohda T, Funabiki K, Horikoshi S, Shirato I, Tomino Y. Significance of serum IgA levels and serum IgA/C3 ratio in diagnostic analysis of patients with IgA nephropathy. J Clin Lab Anal. 2003;17(3):73 – 6.CrossRef
16.
Bennett WM, Kincaidsmith P. Macroscopic hematuria in mesangial IgA nephropathy: correlation with glomerular crescents and renal dysfunction. Kidney Int. 1983;23(2):393–400.CrossRef
Metadaten
Titel
Warfarin-related nephropathy with acute kidney injury in a patient with immunoglobulin A nephropathy
verfasst von
Hiroki Ishii
Keiji Hirai
Katsunori Yanai
Taisuke Kitano
Mitsutoshi Shindo
Haruhisa Miyazawa
Kiyonori Ito
Yuichiro Ueda
Yoshio Kaku
Taro Hoshino
Honami Mori
Susumu Ookawara
Yoshihiko Ueda
Yoshiyuki Morishita
Publikationsdatum
01.11.2018
Verlag
Springer Japan
Erschienen in
CEN Case Reports / Ausgabe 2/2018
Elektronische ISSN: 2192-4449
DOI
https://doi.org/10.1007/s13730-018-0325-2

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