Erschienen in:
01.09.2014 | Letter to the Editor
Possible effect of perampanel on focal status epilepticus after generalized tonic–clonic status epilepticus
verfasst von:
Johannes Rösche, Christina Kampf, Reiner Benecke
Erschienen in:
Acta Neurologica Belgica
|
Ausgabe 3/2014
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Excerpt
Since in refractory status epilepticus (SE), additional glutamate receptors such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and
N-methyl-
d-aspartate (NMDA) receptors are built up in the synaptic membrane [
1], perampanel, a novel noncompetitive AMPA-receptor antagonist, may be effective in this condition. During the treatment of refractory SE, usually a combination therapy of several antiepileptic drugs (AEDs) is established. Therefore, the drug, which has terminated the SE, cannot easily be identified. A possible effect of an AED on the termination of a SE may be supposed, when the termination of a SE is associated with the introduction of an AED in the therapy or an increased dose of an AED in combination with other changes in the antiepileptic medication at the same time [
2]. Here we present a case where perampanel was the last AED introduced in the treatment of a focal SE before its termination 24 h later. …
